We studied the effect of subbacteriostatic azithromycin concentrations on the formation of microbial biofilms by Pseudomonas aeruginosa strains that caused implant-associated infection of large joints. Azithromycin in subinhibitory for planktonic cells concentrations 0.01-0.02 μg/ml stimulated biofilm formation by both clinical and reference P. aeruginosa strains, while in concentrations of 1 μg/ml and higher completely inhibited the growth of both reference and clinical plankton P. aeruginosa strains, but stimulated biofilm formation. Increasing azithromycin concentration to 10 μg/ml led to inhibition of P. aeruginosa biofilm growth.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 744-747, June, 2020
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Babushkina, I.V., Ulyanov, V.Y., Mamonova, I.A. et al. The Effect of Azithromycin on Biofilms Formation by Pathogens of Implant-Associated Infection in Large Joints. Bull Exp Biol Med 169, 798–801 (2020). https://doi.org/10.1007/s10517-020-04982-8
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DOI: https://doi.org/10.1007/s10517-020-04982-8