Activities of prolyl endopeptidase and dipeptidyl peptidase IV in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus were measured in rats with the experimental anxious-depressive syndrome induced by treatment with a dipeptidyl peptidase IV inhibitor during the early postnatal period (days 5-18). Prolyl endopeptidase activity was elevated in the frontal cortex, hypothalamus, and nucleus accumbens. Increased activity of dipeptidyl peptidase IV was observed in the hypothalamus and striatum. Norepinephrine/serotonin reuptake inhibitor, imipramine, and noncompetitive prolyl endopeptidase inhibitor, benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, were shown to abolish depression-like behavior of animals in the forced swimming test. These compounds had a normalizing effect on activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats.
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References
N. A. Krupina, N. N. Zolotov, N. G. Bogdanova, et al., Byull. Eksp. Biol. Med., 142, No. 11, 497–499 (2006).
N. A. Krupina, E. Yu. Kushnareva, N. N. Khlebnikova, et al., Ibid., 147, No. 3, 254–260 (2009).
N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, Ibid., 120, No. 8, 160–164 (1995).
N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, Zh. Vyssh. Nervn. Deyat., 49, No. 5, 865–876 (1999).
E. Yu. Kushnareva, N. A. Krupina, N. N. Khlebnikova, et al., Byull. Eksp. Biol. Med., 151, No. 6, 619–623 (2011).
N. N. Khlebnikova, N. A. Krupina, I. N. Orlova, et al., Ibid., 147, No. 1, 27–31 (2009).
L. F. Barrett, K. A. Lindquist, E. Bliss-Moreau, et al., Perspect. Psychol. Sci., 2, No. 3, 297–311 (2007).
J. R. Kapoor and C. D. Sladek, Am. J. Physiol. Regul. Integr. Comp. Physiol., 280, No. 1, 69–78 (2001).
J. E. Knuuttila, P. Törönén, and E. Castren, Neurochem. Res., 6, 1235–1244 (2004).
M. Maes and S. Bonaccorso, Acta Psychiatr. Scand., 109, No. 2, 126–131 (2004).
M. Maes, F. Goossens, S. Scharpé, et al., Psychiatry Res., 58, No. 3, 217–225 (1995).
P. T. Männistö, P. Tuomainen, O. Kutepova, et al., Pharmacol. Biochem. Behav., 49, No. 1, 33–40 (1994).
G. Racagni and M. Popoli, Dialogues Clin. Neurosci., 10, No. 4, 385–400 (2008).
I. Schulz, B. Gerhartz, A. Neubauer, et al., Eur. J. Biochem., 269, No. 23, 5813–5820 (2002).
S. R. Sesack and A. A. Grace, Neuropsychopharmacology, 35, No. 1, 27–47 (2010).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 10, pp. 387-391, October, 2011
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Khlebnikova, N.N., Krupina, N.A., Kushnareva, E.Y. et al. Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome. Bull Exp Biol Med 152, 409–412 (2012). https://doi.org/10.1007/s10517-012-1540-z
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DOI: https://doi.org/10.1007/s10517-012-1540-z