We studied the correlation between the effect of α-lipoic acid, emoxipin, reamberin, and mexidol on LPO in vitro and the action of these drugs on insulin sensitivity and tolerance to glucose load in vivo. It was found that the preparations producing prooxidant effect in vitro (α-lipoic acid and reamberin) are characterized by pronounced insulin-potentiating activity, but only slightly increase (α-lipoic acid) or even decrease (reamberin) tolerance to glucose load. 3-Hydroxypyridine derivatives (emoxipin and mexidol) producing an antioxidant effect in vitro increase glucose tolerance, but exhibit relatively weak insulin-potentiating activity. These results suggest that differential use of the studied drugs in patients with diabetes mellitus depending on the type of the disease and individual insulin requirement is a promising trend in medical studies.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
I. A. Volchegorskii, M. N. Alekseev, M. I. Volchegorskaya, and L. M. Rassohina, Klin Med., 86, No. 10, 52-60 (2008).
I. A. Volchegorskii, I. I. Dolgushin, O. L. Kolesnikov, and V. E. Tseilikman, Experimental Modeling and Laboratory Evaluation of Adaptive Reactions of the Organism [in Russian], Chelyabinsk (2000),
I. A. Volchegorskii, M. G. Moskvicheva, and E. N. Chashchina, Klin Med., No. 11, 31-35 (2004).
I. A. Volchegorskii, M. G. Moskvicheva, and E. N. Chashchina, Ter. Arkhiv, 77, No. 10, 10-15 (2005).
G. I. Klebanov, O. B. Lyubitskii, O. V. Vasil’eva, et al., Vopr. Med. Khimii, No. 3, 288-300 (2001).
E. B. Men’shikova, V. Z. Lankin, and N. K. Zenkov, et al., Oxidative Stress, Prooxidants and Antioxidants [in Russian], Moscow (2006).
F. Abbasi, Y. D. Chen, H. M. Farin, et al., Am. J. Cardiol., 102, No. 1, 64-69 (2008).
N. Dicter, Z. Madar, and O. Tirosh, J. Nutr., 132, No. 10, 3001- 3006 (2002).
J. L. Evans, B. A. Maddux, and I. D. Goldfine, Antioxid. Redox. Signal., 7, Nos. 7-8, 1040-1052 (2005).
B. J. Goldstein, K. Mahadev, X. Wu, et al., Antioxid. Redox. Signal., 7, Nos. 7-8, 1021-1031 (2005).
W. He, F. J. Miao, D. C. Lin, et al., Nature, 429, 188-193 (2004).
D. Konrad, Antioxid. Redox. Signal., 7, Nos. 7-8, 1032-1039 (2005).
K. Mahadev, H. Motoshima, X. Wu, et al., Mol. Cell. Biol., 24, No. 5, 1844-1854 (2004).
Z. I. Storozheva, A. T. Proshin, V. V. Sherstnev, et al., BMC Pharmacol., 8, No. 1, 1-13 (2008).
G. I. Uwaifo, S. J. Parikh, M. Keil, et al., Clin. Endocrinol. Metab. 87, No. 6, 2899-2905 (2002).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 9, pp. 295-301, September, 2010
Rights and permissions
About this article
Cite this article
Volchegorskii, I.A., Rassokhina, L.M., Miroshnichenko, I.Y. et al. Effect of Pro- and Antioxidants on Insulin Sensitivity and Glucose Tolerance. Bull Exp Biol Med 150, 327–332 (2011). https://doi.org/10.1007/s10517-011-1134-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-011-1134-1