Hemorheological activity of 4-methyl-2,6-di-isobornyl phenol, a new o-isobornyl phenol derivative, was studied under conditions of experimental prolonged partial cerebral ischemia. Brain ischemia is associated with hemorheological disorders which can be characterized as blood hyperviscosity syndrome: increased viscosity of the whole blood (within a wide range of shear rates), plasma viscosity, fi brinogen content in blood plasma, and platelet aggregation; deterioration of platelet deformability and reduced availability of oxygen for tissues. A course (5 days) of intragastric 4-methyl-2,6-di-isobornyl phenol (100 mg/kg) prevented the development of blood hyperviscosity syndrome by modulating blood macrorheology (reduction of plasma viscosity and fi brinogen content) and microrheology (reduction of erythrocyte aggregation and improvement of their deformability).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 6, pp. 660-662, June, 2010
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Plotnikov, M.B., Smolyakova, V.I., Ivanov, I.S. et al. Hemorheological Effects of Ortho-Isobornyl Phenol Derivative under Conditions of Brain Ischemia in Rats. Bull Exp Biol Med 149, 721–723 (2010). https://doi.org/10.1007/s10517-010-1035-8
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DOI: https://doi.org/10.1007/s10517-010-1035-8