Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 µg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27–41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26–58 and 21–29%, respectively, compared to 200 µg/kg simvastatin, p<0.05).
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 171–174, August, 2008
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Ragino, Y.I., Vavilin, V.A., Salakhutdinov, N.F. et al. Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia. Bull Exp Biol Med 146, 206–209 (2008). https://doi.org/10.1007/s10517-008-0252-x
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DOI: https://doi.org/10.1007/s10517-008-0252-x