Abstract
Francisella tularensis is a Gram negative intracellular pathogen that causes the highly debilitating or fatal disease tularemia. F. tularensis can infect a wide range of animals and can be transmitted to humans in a variety of ways, the most common being by the bite of an infected insect or arthropod vector. The attenuated F. tularensis live vaccine strain (LVS) has been used previously under investigational new drug status to vaccinate at-risk individuals. However the history of the strain and lack of knowledge regarding the basis of attenuation has so far prevented its licensing. Therefore the focus of current research is on producing a new vaccine against tularemia that would be suitable for licensing.
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L. Bevanger J. A. Maeland A. I. Naess (1989) ArticleTitleCompetitive enzyme-immunoassay for antibodies to a 43,000- molecular-weight Francisella tularensis outer-membrane protein for the diagnosis of tularemia J. Clin. Microbiol. 27 922–926 Occurrence Handle1:CAS:528:DyaL1MXit12lurY%3D Occurrence Handle2745701
M. Broekhuijsen N. Larsson A. Johansson M. Bystrom U. Eriksson E. Larsson R.G. Prior A. Sjostedt R.W. Titball M. Forsman (2003) ArticleTitleGenome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp tularensis J. Clin. Microbiol. 41 2924–2931 Occurrence Handle10.1128/JCM.41.7.2924-2931.2003 Occurrence Handle1:CAS:528:DC%2BD3sXmsVWms7s%3D Occurrence Handle12843022
J.W. Conlan 2002 Mice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of the pathogen
L.L.Coriel, E.O. King, M.G. Smith 1948, Studies on Tularemia IV Observations on tularemia n control and vaccinated monkeys, J. Immunol. 183--202
S.C. Cowley S.V. Myltseva F.E. Nano (1996) ArticleTitlePhase variation in Francisella tularensis affecting intracellular growthlipopolysaccharide antigenicity and nitric oxide production Mol. Microbiol. 20 867–874 Occurrence Handle1:CAS:528:DyaK28XjsFGjt78%3D Occurrence Handle8793882
H.T. Eigelsbach C.M. Downs (1961) ArticleTitleProphylactic effectiveness of live and killed tularemia vaccines. I J. Immunol. 87 415–425 Occurrence Handle1:STN:280:CC2D3s%2Fpt1w%3D Occurrence Handle13889609
H.T. Eigelsbach V.G. McGann (1984) Genus Francisella Dorofeev 1947, 176AL J.G. Holt (Eds) Bergey’s manual of systematic bacteriology. Vol. 1 The Williams and Wilkins Co BaltimoreMd 394–399
K.L. Elkins S.C. Cowley C.M. Bosio (2003) ArticleTitleInnate and adaptive immune responses to an intracellular bacteriumFrancisella tularensis live vaccine strain Microbes Infect. 5 135–142 Occurrence Handle10.1016/S1286-4579(02)00084-9 Occurrence Handle1:CAS:528:DC%2BD3sXitV2mtr8%3D Occurrence Handle12650771
J. Ellis P.C.F. Oyston M. Green R.W. Titball (2002) ArticleTitleTularemia Clin. Microbiol. Rev. 15 631–646 Occurrence Handle10.1128/CMR.15.4.631-646.2002 Occurrence Handle12364373
M. Ericsson A. Tarnvik K. Kuoppa G. Sandstrom A. Sjostedt (1994) ArticleTitleIncreased synthesis of DnaK, GroEL, and GroES homologs by Francisella tularensis LVS in response to heat and hydrogen peroxide Infect. Immun. 62 178–183 Occurrence Handle1:CAS:528:DyaK2cXntlWhsA%3D%3D Occurrence Handle7903283
M.E. Evans D.W. Gregory W. Schaffner Z.A. McGee (1985) ArticleTitleTularemia: a 30 year experience with 88 cases Medicine (Baltimore) 64 251–69 Occurrence Handle1:STN:280:BiqB3sbotlw%3D
Foshay L. 1946. A comparative study of the treatment of tularemia with immune serumhyperimmune serum and strepomycin. Am. J. Med. 180–188.
L. Foshay (1950) ArticleTitleTularemia Annu. Rev. Microbiol. 4 313–330 Occurrence Handle10.1146/annurev.mi.04.100150.001525 Occurrence Handle1:STN:280:Cy6D2sjht1A%3D Occurrence Handle14847574
L. Foshay W.H. Hesselbrock H.J. Wittenberg A.H. Rodenberg (1942) ArticleTitleVaccine prophylaxis against tularemia in man Am. J. Public Health 32 1131–1145
M. Fulop R. Manchee R. Titball (1995) ArticleTitleRole of lipopolysaccharide and a major outer-membrane protein from Francisella tularensis n the induction of immunity against tularemia Vaccine 13 1220–1225 Occurrence Handle10.1016/0264-410X(95)00062-6 Occurrence Handle1:CAS:528:DyaK2MXpt1yrsrw%3D Occurrence Handle8578807
M. Fulop P. Mastroeni M. Green R.W. Titball (2001) ArticleTitleRole of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis Vaccine 19 4465–4472 Occurrence Handle10.1016/S0264-410X(01)00189-X Occurrence Handle1:CAS:528:DC%2BD3MXlsFylsLs%3D Occurrence Handle11483272
H. Gil J.L. Benach D.G. Thanassi (2004) ArticleTitlePresence of pili on the surface of Francisella tularensis Infect. Immun. 72 3042–3047 Occurrence Handle10.1128/IAI.72.5.3042-3047.2004 Occurrence Handle1:CAS:528:DC%2BD2cXjslaju7w%3D Occurrence Handle15102818
V. Gill B.A. Cunha (1997) ArticleTitleTularemia pneumonia Semin. Respir. Infect. 12 61–67 Occurrence Handle1:STN:280:ByiB2M7ntVM%3D Occurrence Handle9097380
D. Gurycova (1998) ArticleTitleFirst isolation of Francisella tularensis subsp. tularensis in Europe Eur. J. Epidemiol. 14 797–802 Occurrence Handle10.1023/A:1007537405242 Occurrence Handle1:STN:280:DyaK1M7isF2mtw%3D%3D Occurrence Handle9928875
M.G. Hartley M. Green G. Choules D. Rogers D.G.C. Rees S. Newstead A. Sjostedt R.W. Titball (2004) ArticleTitleProtection afforded by heat shock protein 60 from Francisella tularensis is due to copurified lipopolysaccharide Infect. Immun. 72 4109–4113 Occurrence Handle10.1128/IAI.72.7.4109-4113.2004 Occurrence Handle1:CAS:528:DC%2BD2cXlslWisLg%3D Occurrence Handle15213156
D.G. Hollis R.E. Weaver A.G. Steigerwalt J.D. Wenger C.W. Moss D.J. Brenner (1989) ArticleTitleFrancisella philomiragia comb. nov. (formerly Yersinia philomiragia) and Francisella tularensis biogroup novicida (formerly Francisella novicida) associated with human disease J. Clin. Microbiol. 27 1601–8 Occurrence Handle1:STN:280:BiaA2MbotFQ%3D Occurrence Handle2671019
R.B. Hornick A.T. Dawkins H.T. Eigelsbach J.J. Tulis (1966) ArticleTitleOral tularemia vaccine in man Antimicrob. Agents Chemother. 6 11–14 Occurrence Handle1:STN:280:CCeD3crlvVM%3D
R.B. Hornick H.T. Eigelsbach (1966) ArticleTitleAerogenic immunization of man with live tularemia vaccine Bacteriol. Rev. 30 532–538 Occurrence Handle1:STN:280:CCiD3Mzot1U%3D Occurrence Handle5917334
P.J. Kadull H.R. Reames L.L. Coriell L. Foshay (1950) ArticleTitleStudies on tularemia. V. Immunisation of man J. Immunol. 65 425–435 Occurrence Handle1:STN:280:Cy6D38vksFE%3D Occurrence Handle14794905
J. Karlsson R.G. Prior K. Williams L. Lindler K.A. Brown N. Chatwell K. Hjalmarsson N. Loman K.A. Mack M. Pallen M. Popek G. Sandstrom A. Sjostedt T. Svensson I. Tamas S.G. Andersson B.W. Wren P.C.F. Oyston R.W. Titball (2000) ArticleTitleSequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways targets for the construction of a rationally attenuated auxotrophic vaccine Microb. Comp. Genomics 5 25–39 Occurrence Handle10.1089/10906590050145249 Occurrence Handle1:CAS:528:DC%2BD3cXntFKku7w%3D Occurrence Handle11011763
L.M. Khatenever (1943) The allergic diagnosis specific prophylaxis and vaccine therapy of tularemia E.B. Balsky I.G. Kochergin V.V. Porin (Eds) Microbiology and epidemiology Medical Publications Ltd London 62–79
C.M. Lauriano J.R. Barker F.E. Nano B.P. Arulanandarn K.E. Klose (2003) ArticleTitleAllelic exchange in Francisella tularensis using PCR products FEMS Microbiol. Lett. 229 195–202 Occurrence Handle10.1016/S0378-1097(03)00820-6 Occurrence Handle1:CAS:528:DC%2BD3sXpvVajtL4%3D Occurrence Handle14680699
G.W. McCoy C.W. Chapin (1912) ArticleTitleFurther observations on a plague-like disease of rodents with a preliminary note on the causative agentBacterium tularense J. Infect. Dis. 10 61–72
R.G. Prior L. Klasson P. Larsson K. Williams L. Lindler A. Sjostedt T. Svensson I. Tamas B.W. Wren P.C.F. Oyston S.G.E. Andersson R.W. Titball (2001) ArticleTitlePreliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4 J. Appl. Microbiol. 91 614–620 Occurrence Handle10.1046/j.1365-2672.2001.01499.x Occurrence Handle1:CAS:528:DC%2BD3MXnvVamtbY%3D Occurrence Handle11576297
G. Sandstrom (1994) ArticleTitleThe tularemia vaccine J. Chem. Tech. Biotechnol. 59 315–320 Occurrence Handle10.1002/jctb.280590402 Occurrence Handle1:STN:280:ByuB2M%2FktVM%3D
G. Sandstrom A. Tarnvik H. Wolf-watz (1987) ArticleTitleImmunospecific T-lymphocyte stimulation by membrane proteins from Francisella tularensis J. Clin. Microbiol. 25 641–644 Occurrence Handle1:STN:280:BiiC1MrjslA%3D Occurrence Handle3494744
H. Shen W.X. Chen J.W. Conlan (2004) ArticleTitleSusceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen Vaccine 22 2116–2121 Occurrence Handle10.1016/j.vaccine.2003.12.003 Occurrence Handle1:CAS:528:DC%2BD2cXktV2lsbw%3D Occurrence Handle15149767
A. Sjostedt G. Sandstrom A. Tarnvik (1990) ArticleTitleSeveral membrane polypeptides of the live vaccine strain Francisella tularensis LVS stimulate T cells from naturally infected individuals J. Clin. Microbiol. 28 43–48 Occurrence Handle1:STN:280:By%2BC3s7gt10%3D Occurrence Handle1688874
A. Sjostedt G. Sandstrom A. Tarnvik (1992) ArticleTitleHumoral and cell-mediated immunity in mice to a 17-kilodalton lipoprotein of Francisella tularensis expressed by Salmonella typhimurium Infect. Immun. 60 2855–2862 Occurrence Handle1:STN:280:By2A3cjptFI%3D Occurrence Handle1612751
H.M. Surcel M. Sarvas I.M. Helander E. Herva (1989) ArticleTitleMembrane proteins of Franceisella tularensis LVS differ in ability to induce proliferation of lymphocytes from tularemia-vaccinated individuals Microb. Pathogen. 7 411–419 Occurrence Handle10.1016/0882-4010(89)90021-1 Occurrence Handle1:CAS:528:DyaK3cXhvFCqurc%3D
A. Tarnvik (1989) ArticleTitleNature of protective immunity to Francisella tularensis Rev. Infect. Dis. 11 440–451 Occurrence Handle1:STN:280:BiaA3MjhtlA%3D Occurrence Handle2665002
W.D. Tigertt (1962) ArticleTitleSoviet viable Pasteurella tularensis vaccines: a review of selected articles Bacteriol. Rev. 26 354–373 Occurrence Handle1:CAS:528:DyaF3sXhtVOlsw%3D%3D Occurrence Handle13985026
M.J. Whipp (2003) ArticleTitleCharacterization of a novicida-like subspecies of Francisella tularensis isolated in Australia J. Med. Microbiol. 52 839–842 Occurrence Handle10.1099/jmm.0.05245-0 Occurrence Handle12909664