Abstract
High-resolution imaging provides a significant means for accurate material modulus estimation and mechanical characterization. Within the realm of in vivo soft tissue characterization, particularly on small biological length scales such as arterial atherosclerotic plaques, optical coherence tomography (OCT) offers a desirable imaging modality with higher spatial resolution and contrast of tissue as compared with intravascular ultrasound (IVUS). Based on recent advances in OCT imaging and elastography, we present a fully integrated system for tissue elasticity reconstruction, and assess the benefits of OCT on the distribution results of four representative tissue block models. We demonstrate accuracy, with displacement residuals on the order of 10−6 mm (more than 3 orders of magnitude less than average calculated displacements), and high-resolution estimates, with the ability to resolve inclusions of 0.15 mm diameter.
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References
Baldewsing, R. A., C. L. de Korte, J. A. Schaar, F. Mastik, and A. F. W. van der Steen. Finite element modeling and intravascular ultrasound elastography of vulnerable plaques: Parameter variation. Ultrasonics 42:723–729, 2004.
Bouma, B. E., and G. J. Tearney. Power-efficient nonreciprocal interferometer and linear-scanning fiber-optic catheter for optical coherence tomography. Opt. Lett. 24:531–533, 1999.
Chan, R. C., A. H. Chau, W. C. Karl, S. Nadkarni, A. S. Khalil, N. Iftimia, M. Shishkov, G. J. Tearney, M. R. Kaazempur-Mofrad, and B. E. Bouma. OCT-based arterial elastography: Robust estimation exploiting tissue biomechanics. Opt. Express 12:4558–4572, 2004.
Chau, A. H., R. C. Chan, M. Shishkov, B. MacNeill, N. Iftima, G. J. Tearney, R. D. Kamm, B. E. Bouma, and M. R. Kaazempur-Mofrad. Mechanical analysis of atherosclerotic plaques based on optical coherence tomography. Ann. Biomed. Eng. 32:1494–1503, 2004.
Cheng, G. C., H. M. Loree, R. D. Kamm, M. C. Fishbein, and R. T. Lee. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation 87:1179–1187, 1993.
Constantinides, P. Plaque fissure in human coronary thrombosis. J. Atheroscler. Res. 6:1–17, 1966.
Costa, K. D., J. W. Holmes, and A. D. McCulloch. Modeling cardiac mechanical properties in three dimensions. Philos. Trans. R. Soc. Lond. A. 359:1233–1250, 2001.
Davies, M. J., and T. Thomas. The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 294:225–229, 1981.
de Korte, C. L., A. F. W. van der Steen, E. I. Céspedes, G. Pasterkamp, S. G. Carlier, F. Mastik, A. H. Schoneveld, P. W. Serruys, and N. Bom. Characterization of plaque components and vulnerability with intravascular ultrasound elastography. Phys. Med. Biol. 45:1465–1475, 2000.
Doyley, M. M., P. M. Meaney, and J. C. Bamber. Evaluation of an iterative reconstruction method for quantitative elastography. Phys. Med. Biol. 45:1521–1540, 2000.
Doyley, M. M., F. Mastik, C. L. de Korte, S. G. Carlier, E. I. Céspedes, P. W. Serruys, N. Bom, and A. F. W. van der Steen. Advancing intravascular ultrasonic palpation toward clinical applications. Ultrasound Med. Biol. 27:1471–1480, 2001.
Duck, F. A. Physical Properties of Tissues—A Comprehensive Reference Book. Sheffield, UK: Academic Press, 1990.
Fung, Y. C., K. Fronek, and P. Patitucci. Pseudoelasticity of arteries and the choice of its mathematical expression. Am. Physiol. Soc. 237:H620–H631, 1979.
Hansen, P. C. Rank-Deficient and Discrete Ill-Posed Problems: Numerical Aspects of Linear Inversion. Philadelphia, PA: SIAM, 1998.
Holzapfel, G. A., R. Eberlein, P. Wriggers, and H. W. Weizsäcker. Large strain analysis of soft biological and rubber-like membranes: Formulation and finite element analysis. Comput. Methods Appl. Mech. Eng. 132:45–61, 1996.
Holzapfel, G. A., T. C. Gasser, and R. W. Ogden. Comparison of a multi-layer structural model for arterial walls with a fung-type model, and issues of material stability. J. Biomech. Eng. 126:264–275, 2004.
Huang, D., E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, et al. Optical coherence tomography. Science 254:1178–1181, 1991.
Jang, I. K., B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound. J. Am. Coll. Cardiol. 39:604–609, 2002.
Kallel, F., and M. Bertrand. Tissue elasticity reconstruction using linear perturbation method. IEEE Trans. Med. Imaging 15:299–313, 1996.
Mow, V. C., S. C. Kuei, W. M. Lai, and C. G. Armstron. Biphasic creep and relaxation of articular cartilage in compression: Theory and experiments. J. Biomech. Eng. 102:73–84, 1980.
Oomens, C. W. J., D. H. Campen, and H. J. vanGrootenboer. A mixture approach to the mechanics of skin. J. Biomech. 20:877–885, 1987.
Ophir, J., E. I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li. Elastography: A quantitative method for imaging the elasticity in biological tissues. Ultrason. Imaging 13:111–134, 1991.
Ophir, J., E. I. Céspedes, B. Garra, H. Ponnekanti, Y. Huang, and N. Maklad. Elastography: Ultrasonic imaging of tissue strain and elastic modulus in vivo. Eur. J. Ultrasound 3:49–70, 1996.
Richardson, P. D., M. J. Davies, and G. V. R. Born. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet 8669:941–944, 1989.
Samani, A., J. Bishop, C. Luginbuhl, and D. B. Plewes. Measuring the elastic modulus of ex vivo small tissue samples. Phys. Med. Biol. 48:2183–2198, 2003.
Schaar, J. A., C. L. de Korte, F. Mastik, C. Strijder, G. Pasterkamp, E. Boersma, P. W. Serruys, and A. F. W. van der Steen. Characterizing vulnerable plaque features with intravascular elastography. Circulation 108:1–6, 2003.
Skovoroda, A. R., S. Y. Emelianov, and M. O'Donnell. Reconstruction of tissue elasticity based on ultrasonic displacement and strain images. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 42:747–765, 1995.
Tearney, G. J., M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto. In vivo endoscopic optical biopsy with optical coherence tomography. Science 276:2037–2039, 1997.
Yorkey, T. J., J. G. Webster, and W. J. Tompkins. Comparing reconstruction algorithms for electrical impedance tomography. IEEE Trans. Biomed. Eng. 34:843–852, 1987.
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Khalil, A.S., Chan, R.C., Chau, A.H. et al. Tissue Elasticity Estimation with Optical Coherence Elastography: Toward Mechanical Characterization of In Vivo Soft Tissue. Ann Biomed Eng 33, 1631–1639 (2005). https://doi.org/10.1007/s10439-005-6766-3
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DOI: https://doi.org/10.1007/s10439-005-6766-3