Comprehensive Registry of Esophageal Cancer in Japan, 2007

Preface 2007

We deeply appreciate the great contributions of many physicians in the registry of esophageal cancer cases. The Comprehensive Registry of Esophageal Cancer in Japan, 2007, was published here, despite some delay. The registry complies with the Act for the Protection of Personal Information. The encryption with a HASH function is used for ‘‘anonymity in an unlinkable fashion’’.

We briefly summarized the Comprehensive Registry of Esophageal Cancer in Japan, 2007. Japanese Classification of Esophageal Cancer 10th and UICC TNM Classification 6th were used for cancer staging according to the subjected year. A total of 5216 cases were registered from 257 institutions in Japan. Tumor locations were cervical: 4.4 %, upper thoracic: 12.7 %, middle thoracic: 49.5 %, lower thoracic: 25.1 % and EG junction: 5.9 %. Superficial carcinomas (Tis, T1a, and T1b) were 35.7 %. As for the histologic type of biopsy specimens, squamous cell carcinoma and adenocarcinoma accounted for 90.1 % and 3.9 %, respectively. Regarding clinical results, the 5-year survival rates of patients treated using endoscopic mucosal resection, concurrent chemoradiotherapy, radiotherapy alone, chemotherapy alone, or esophagectomy were 88.1, 25.1, 16.0, 9.4, and 52.8 %, respectively. Esophagectomy was performed in 2834 cases. Concerning the approach used for esophagectomy, 19.8 % of the cases were treated thoracoscopically. The operative mortality (within 30 days after surgery) was 0.67 % and the hospital mortality was 1.27 %.

We hope that this Comprehensive Registry of Esophageal Cancer in Japan for 2007 will help to improve all aspects of the diagnosis and treatment of esophageal cancer in Japan.

Contents

• I. Clinical factors of esophageal cancer patients treated in 2007

  • 1. Institution-registered cases in 2007

  • 2. Patient background

    • Table 1 Age and gender

    • Table 11 Primary treatment

    • Table 12 Tumor location

    • Table 15 Histologic types of biopsy specimens

    • Table 16 Depth of tumor invasion, cT (UICC TNM 6th)

    • Table 17 Lymph node metastasis, cN (UICC TNM 6th)

    • Table 18 Distant metastasis, cM (UICC TNM 6th)

    • Table 20 Clinical stage (UICC TNM 6th)

• II. Results of endoscopically treated patients in 2007

  • Table 22 Details of endoscopic treatment

  • Table 26 Complications of EMR/ESD

  • Table 30 Pathological depth of tumor invasion of EMR/ESD specimens

  • Figure 1 Survival of patients treated with EMR/ESD

    Fig. 1

    

    Survival of patients treated with EMR/ESD

  • Figure 3 Survival of patients treated with EMR/ESD according to the pathological depth of tumor invasion (pT)

    Fig. 3

    

    Survival of patients treated with EMR/ESD according to the pathological depth of tumor invasion (pT)

  • Figure 4 Survival of patients treated with EMR/ESD according to the lymphatic and venous invasion

    Fig. 4

    

    Survival of patients treated with EMR/ESD according to the lymphatic and venous invasion

• III. Results in patients treated with chemotherapy and/or radiotherapy in 2007

  • Table 33 Dose of radiation (non-surgically treated cases)

  • Table 34 Dose of radiation (surgically treated cases)

  • Figure 6 Survival of patients treated with chemotherapy and/or radiotherapy (cStage I-IIA)

    Fig. 6

    

    Survival of patients treated with chemotherapy and/or radiotherapy (cStage I-IIA)

  • Figure 7 Survival of patients treated with chemotherapy and/or radiotherapy (cStage IIB-IVB)

    Fig. 7

    

    Survival of patients treated with chemotherapy and/or radiotherapy (cStage IIB-IVB)

• IV. Results in patients underwent esophagectomy in 2007

  • Table 40 Treatment modalities of esophagectomy

  • Table 42 Tumor location

  • Table 43 Approaches to tumor resection

  • Table 44 Endoscopic surgery

  • Table 45 Fields of lymph node dissection according to the location of the tumor

  • Table 47 Reconstruction route

  • Table 48 Organs used for reconstruction

  • Table 55 Histological classification

  • Table 56 Depth of tumor invasion, pT (JES 10th)

  • Table 58 Pathological grading of lymph node metastasis, pN (JES 10th)

  • Table 59 Numbers of the metastatic nodes

  • Table 60 Pathological findings of distant organ metastasis, pM (JES 10th)

  • Table 61 Residual tumor, R

  • Table 72 Causes of death

  • Figure 8 Survival of patients underwent esophagectomy

    Fig. 8

    

    Survival of patients underwent esophagectomy

  • Figure 9 Survival of patients underwent esophagectomy according to clinical stage (JES TNM 10th)

    Fig. 9

    

    Survival of patients underwent esophagectomy according to clinical stage (JES TNM 10th)

  • Figure 10 Survival of patients underwent esophagectomy according to clinical stage (UICC TNM 6th)

    Fig. 10

    

    Survival of patients underwent esophagectomy according to clinical stage (UICC TNM 6th)

  • Figure 11 Survival of patients underwent esophagectomy according to the depth of tumor invasion: pT (JES TNM 10th)

    Fig. 11

    

    Survival of patients underwent esophagectomy according to the depth of tumor invasion: pT (JES TNM 10th)

  • Figure 12 Survival of patients underwent esophagectomy according to the depth of tumor invasion: pT (UICC TNM 6th)

    Fig. 12

    

    Survival of patients underwent esophagectomy according to the depth of tumor invasion: pT (UICC TNM 6th)

  • Figure 13 Survival of patients underwent esophagectomy according to lymph node metastasis: pN (JES TNM 10th)

    Fig. 13

    

    Survival of patients underwent esophagectomy according to lymph node metastasis: pN (JES TNM 10th)

  • Figure 14 Survival of patients underwent esophagectomy according to lymph node metastasis: pN (UICC TNM 6th)

    Fig. 14

    

    Survival of patients underwent esophagectomy according to lymph node metastasis: pN (UICC TNM 6th)

  • Figure 15 Survival of patients underwent esophagectomy according to number of metastatic node

    Fig. 15

    

    Survival of patients underwent esophagectomy according to number of metastatic node

  • Figure 16 Survival of patients underwent esophagectomy according to pathological stage (JES TNM 10th)

    Fig. 16

    

    Survival of patients underwent esophagectomy according to pathological stage (JES TNM 10th)

  • Figure 17 Survival of patients underwent esophagectomy according to pathological stage (UICC TNM 6th)

    Fig. 17

    

    Survival of patients underwent esophagectomy according to pathological stage (UICC TNM 6th)

  • Figure 18 Survival of patients underwent esophagectomy according to residual tumor (R)

    Fig. 18

    

    Survival of patients underwent esophagectomy according to residual tumor (R)

I. Clinical factors of esophageal cancer patients treated in 2007

Institution-registered cases in 2007

Institution
Aichi Cancer Center
Aizawa Hospital
Akita University Hospital
Arao Municipal Hospital
Asahikawa Medical College Hospital
Beppu Medical Center
Chiba Cancer Center
Chiba Medical Center
Chiba Prefectural Sawara Hospital
Chiba University Hospital
Chibaken Saiseikai Narashino Hospital
Dokkyo Medical University Hospital
Fujioka General Hospital
Fujisawa Shounandai Hospital
Fujita Health University
Fukui Prefectural Hospital
Fukui University Hospital
Fukuoka Dental College and Dental Hospital
Fukuoka Saiseikai General Hospital
Fukuoka University Hospital
Fukuoka Wajiro Hospital
Fukushima Medical University Hospital
Gifu Prefectural General Medical Center
Gifu University Hospital
Gunma Central General Hospital
Gunma Prefectural Cancer Center
Gunma University Hospital
Gunmaken Saiseikai Maebashi Hospital
Hakodate Goryokaku Hospital
Hakodate National Hospital
Hamamatsu University School of Medicine, University Hospital
Health Insurance Naruto Hospital
Heartlife Hospital
Higashiosaka City General Hospital
Hino Memorial Hospital
Hiratsuka City Hospital
Hiratsuka Kyosai Hospital
Hiroshima City Asa Hospital
Hiroshima University Research Institute for Radiation Biology Medicine
Hitachi General Hospital
Hokkaido kin-ikyo Central Hospital
Hokkaido P.W.F.A.C Obihiro-Kosei General Hospital
Hokkaido University Hospital
Hyogo Cancer Center
Hyogo College of Medicine
Ibaraki Prefectural Central Hospital
Ida Municipal Hospital
Iizuka Hospital
Imazu Surgical Clinic
Inazawa City Hospital
International University of Health and Welfare Hospital
Ishikawa Prefectural Central Hospital
Iwakuni Medical Center
Iwate Medical University Hospital
Japanese Red Cross Kyoto Second Hospital
Japanese Red Cross Shizuoka Hospital
Jichi Medical University Hospital
Juntendo University Hospital
Junwakai Memorial Hospital
Kagawa Prefectural Central Hospital
Kagawa Rosai Hospital
Kagawa University Hospital
Kagoshima Kenritsu Satsunan Hospital
Kagoshima University Hospital
Kanazawa Medical University Hospital
Kanazawa University Hospital
Kansai Medical University Hirakata Hospital
Kansai Rosai Hospital
Kashiwa Kousei General Hospital
Kawakita General Hospital
Kawasaki Hospital
Kawasaki Medical School Hospital
Kawasaki Municipal Hospital
Keio University Hospital
Keiyukai Sapporo Hospital
Kikuna Memorial Hospital
Kinki Central Hospital
Kinki University Hospital
Kiryu Kosei General Hospital
Kishiwada City Hospital
Kitakyushu Municipal Medical Center
Kitano Hospital
Kitasato University Hospital
Kitasato University Kitasato Institute Medical Center Hospital
Kobe City Medical Center General Hospital
Kobe University Hospital
Kochi University Hospital
Kokura Memorial Hospital
Kumamoto City Hospital
Kumamoto University Hospital
Kurashiki Central Hospital
Kurume First Social Insurance Hospital
Kurume University Hospital
Kuwana Medical Center
Kyorin University Hospital
Kyoto University Hospital
Kyushu University Hospital
Kyusyu Medical Center
Machida Municipal Hospital
Matsuda Hospital
Matsumoto Medical Center
Matsushita Memorial Hospital
Matsuyama Red Cross Hospital
Mie University Hospital
Mito Red Cross Hospital
Miyazaki Konan Hospital
Murakami General Hospital
Musashino Red Cross Hospital
Nagahama City Hospital
Nagano Red Cross Hospital
Nagasaki University Hospital
Nagayoshi General Hospital
Nagoya City University Hospital
Nagoya Daiichi Red Cross Hospital
Nagoya University Hospital
Nara Hospital Kinki University Faculty of Medicine
Nara Medical University Hospital
National Cancer Center Hospital
National Cancer Center Hospital East
National Center for Global Health and Medicine
National Defense Medical College Hospital
National Hospital Organization Chiba Medical Center
National Hospital Organization Chiba-East Hospital
National Hospital Organization Fukuoka-East Medical Center
National Hospital Organization Hokkaido Cancer Center
National Hospital Organization Kure Medical Center
National Hospital Organization Kyushu Cancer Center
National Hospital Organization Nagoya Medical Center
National Hospital Organization Osaka National Hospital
National Hospital Organization Tokyo Medical Center
Nihon University Itabashi Hospital
Niigata Cancer Center Hospital
Niigata City General Hospital
Niigata Prefectural Shibata Hospital
Niigata University Medical and Dental Hospital
Nikko Memorial Hospital
Nippon Medial School Hospital
Nippon Medical School Chiba Hokusoh Hospital
Nippon Medical School Hospital
Nippon Medical School Musashi Kosugi Hospital
Nippon Medical School Tama Nagayama Hospital
Nishi-Kobe Medical Center
Nishinomiya Municipal Central Hospital
NTT West Japan Osaka Hospital
Numazu City Hospital
Ohta General Hospital Foundation Ohta Nishinouchi Hospital
Oita Red Cross Hospital
Oita University Hospital
Okayama Saiseikai General Hospital
Okayama University Hospital
Omuta City Hospital
Onomichi Municipal Hospital
Osaka City General Medical Center
Osaka City University Hospital
Osaka Hospital of Japan Seafarers Relief Association
Osaka Koseinenkin Hospital
Osaka Medical Center for Cancer and Cardiovascular Diseases
Osaka Medical College Hospital
Osaka Prefectural Hospital Organization Osaka General Medical Center
Osaka Red Cross Hospital
Osaka University Hospital
Otsu Red Cross Hospital
Rinku General Medical Center
Ryukyu University Hospital
Saga University Hospital
Saga-Ken Medical center Koseikan
Saiseikai Utsunomiya Hospital
Saiseikai Yahata General Hospital
Saitama City Hospital
Saitama Medical Center
Saitama Medical Center Jichi Medical University
Saitama Medical University Hospital
Saitama Medical University International Medical Center
Saitama Prefectural Cancer Center
Saitama Social Insurance Hospital
Sakai Municipal Hospital
Saku Central Hospital
Sano Kousei General Hospital
Seirojika National Hospital University Hospital
Sendai City Hospital
Sendai Medical Center
Shiga Medical Center for Adults
Shiga University of Medical Science Hospital
Shikoku Cancer Center
Shimada Hospital
Shimane University Hospital
Shimizu Welfare Hospital
Shinshu University Hospital
Shizuoka Cancer Center
Shizuoka City Shizuoka Hospital
Shizuoka General Hospital
Showa University Hospital
Social Insurance Omuta Tenryo Hospital
Social Insurance Tagawa Hospital
Social Insurance Yokohama Central Hospital
Sonoda First Hospital
Sugita Genpaku Memorial Obama Municipal Hospital
Suita Municipal Hospital
Suwa Red Cross Hospital
Syowa University Hospital
Syowa University Toyosu Hospital
Takaoka Hospital
Takasago Municipal Hospital
Takatsuki Red Cross Hospital
Tenri Hospital
The Cancer Institute Hospital of JFCR
The Jikei University Hospital
The Research Center Hospital for Charged Particle Therapy of the NIRS
Tochigi Cancer Center
Toho University Hospital
Toho University Omori Medical Center
Tohoku Kosai Hospital
Tohoku University Hospital
Tokai University Hospital
Tokushima Municipal Hospital
Tokushima Red Cross Hospital
Tokushima University Hospital
Tokyo Dental College Ichikawa General Hospital
Tokyo Jikeikai Medical
Tokyo Medical and Dental University Hospital
Tokyo Medical University Hospital
Tokyo Metropolitan Cancer and Infectious Center Komagome Hospital
Tokyo Metropolitan Health and Medical Corporation Toshima Hospital
Tokyo University Hospital
Tokyo Women’s Medical University Hospital
Tokyo Women’s Medical University Medical Center East
Tonan Hospital
Tone Central Hospital
Toranomon Hospital
Tottori Prefectural Central Hospital
Tottori University Hospital
Toyama Prefectural Central Hospital
Toyama University Hospital
Tsuchiura Kyodo Hospital
Tsukuba University Hospital
University Hospital, Kyoto Prefectural University of Medicine
University of Miyazaki Hospital
Wakayama Medical University Hospital
Yamagata Prefectural and Sakata Municipal Hospital Organization
Yamagata Prefectural Central Hospital
Yamagata Prefectural Shinjo Hospital
Yamaguchi-ken Saiseikai Shimonoseki General Hospital
Yamanashi Prefectural Central Hospital
Yamanashi University Hospital
Yokohama City Municipal Hospital
Yokohama City University Hospital
Yokohama City University Medical Center
Yuri General Hospital

1. (Total 257 institutions)

Patient background

Table 1 Age and gender

Table 11 Primary treatment

Table 12 Tumor location

Table 15 Histologic types of biopsy specimens

Table 16 Depth of tumor invasion, cT (UICC TNM 6th)

Table 17 Lymph node metastasis, cN (UICC TNM 6th)

Table 18 Distant metastasis, cM (UICC TNM 6th)

Table 20 Clinical Stage (UICC TNM 6th)

II. Results of endoscopically treated patients in 2007

Table 22 Details of endoscopic treatment

Table 26 Complications of EMR/ESD

Table 30 Pathological depth of tumor invasion of EMR/ESD specimens

III. Results in patients treated with chemotherapy and/or radiotherapy in 2007

Table 33 Dose of radiation (non-surgically treated cases)

Table 34 Dose of radiation (surgically treated cases)

IV. Results in patients underwent esophagectomy in 2007

Table 40 Treatment modalities of esophagectomy

Table 42 Tumor location

Table 43 Approaches to tumor resection

Table 44 Endoscopic surgery

Table 45 Fields of lymph node dissection according to the location of the tumor

Table 47 Reconstruction route

Table 48 Organs used for reconstruction

Table 55 Histological classification

Table 56 Depth of tumor invasion, pT (JES 10th)

Table 58 Pathological grading of lymph node metastasis, pN (JES 10th)

Table 59 Numbers of the metastatic nodes

Table 60 Pathological findings of distant organ metastasis, pM (JES 10th)

Table 61 Residual tumor, R

Table 72 Causes of death