Abstract
Purpose
This study evaluates the relevance to human retinopathy of electroretinograms (ERGs) from the spontaneously diabetic Goto-Kakizaki (GK) rat.
Methods
Starting from 4 weeks of age, we obtained ERGs every 4 weeks from six GK rats and seven Wistar (control) rats, and from two GK and two Wistar rats at 14 days of age. The a-wave, b-wave, and oscillatory potentials (OPs) were recorded after stimulation with a single bright flash. We compared the amplitudes and implicit times and measured a-wave latencies to evaluate photoreceptor function.
Results
The amplitudes of the a-wave, b-wave, and OPs (O1 and O2) of the GK rats were reduced between 4 and 48 weeks of age. The time-dependent courses of change in a-wave, b-wave, and O2 amplitude did not differ between the two groups. The a-wave latencies in GK rats were significantly prolonged, but not the implicit times of OPs. At 14 days of age, the a-wave amplitudes were significantly smaller in GK than in Wistar rats.
Conclusion
Functional abnormalities of photoreceptors might be induced by inheritable degeneration at an early age in the GK rat. Although hyperglycemia would cause retinal hypoxia, it would not be severe enough to disturb the generation of OPs. Jpn J Ophthalmol 2006;50:211–216 © Japanese Ophthalmological Society 2006
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References
H Ikeda A Shino T Matsuo H Iwatsuka Z Suzuki (1981) ArticleTitleA new genetically obese-hyperglycemic rat (Wistar fatty) Diabetes 30 1045–1050 Occurrence Handle7030830 Occurrence Handle1:STN:280:DyaL38%2FntlGisw%3D%3D
K Kawano T Hirashima S Mori et al. (1992) ArticleTitleSpontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain Diabetes 41 1422–1428 Occurrence Handle1397718 Occurrence Handle1:STN:280:DyaK3s%2Fht1GitA%3D%3D
N Rakieten ML Rakieten MR Nadkarni (1963) ArticleTitleStudies on the diabetogenic action of streptozotocin Cancer Chemother Rep 29 91–98
PS Schein DA Cooney ML Vemon (1967) ArticleTitleThe use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity Cancer Res 27 2324–2332 Occurrence Handle4295475 Occurrence Handle1:CAS:528:DyaF1cXns1yjtg%3D%3D
L Von Sallmann P Grimes (1971) ArticleTitleEye changes in streptozotocin diabetes in rats Am J Ophthalmol 1 312–319 Occurrence Handle5542130 Occurrence Handle1:STN:280:CS6C3crjtlI%3D
Y Goto M Kakizaki (1975) ArticleTitleThe spontaneous-diabetes rat: a model of noninsulin dependent diabetes mellitus Proc Jpn Acad 51 80–85
Y Goto K Suzuki T Ono et al. (1988) ArticleTitleDevelopment of diabetes in the non-obese NIDDM rat (GK rat) Adv Exp Med Biol 246 29–31 Occurrence Handle3074659 Occurrence Handle1:STN:280:DyaL1M3mvF2ksQ%3D%3D
B Portha P Serradas D Bailbe et al. (1991) ArticleTitleβ-Cell insensitivity to glucose in the GK rat, a spontaneous non-obese model for Type II diabetes Diabetes 40 486–491 Occurrence Handle2010050 Occurrence Handle1:CAS:528:DyaK3MXktVKhu7g%3D
D Yonemura K Tsuzuki T Aoki (1966) ArticleTitleClinical importance of the oscillatory potential in the human ERG Acta Ophthalmol (Copenh) Suppl 70 115–123
Y Shirao K Kawasaki (1998) ArticleTitleElectrical responses from diabetic retina Prog Retin Eye Res 17 59–76 Occurrence Handle9537795 Occurrence Handle10.1016/S1350-9462(97)00005-0 Occurrence Handle1:STN:280:DyaK1c7nsl2jsw%3D%3D
L Wachtmeister (1998) ArticleTitleOscillatory potentials in the retina: what do they reveal? Prog Retin Eye Res 17 485–521 Occurrence Handle9777648 Occurrence Handle10.1016/S1350-9462(98)00006-8 Occurrence Handle1:STN:280:DyaK1cvltVyhsQ%3D%3D
E Fujiwara H Qiu M Liu et al. (2002) ArticleTitleReliability and significance of measurements of a-wave latency in rats Jpn J Ophthalmol 46 419–425 Occurrence Handle12225821 Occurrence Handle10.1016/S0021-5155(02)00506-3
H Qiu E Fujiwara M Liu et al. (2002) ArticleTitleEvidence that a-wave latency of the electroretinogram is determined solely by photoreceptors Jpn J Ophthalmol 46 426–432 Occurrence Handle12225822 Occurrence Handle10.1016/S0021-5155(02)00505-1
A Kowluru RA Kowluru A Yamazaki (1992) ArticleTitleFunctional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus Diabetologia 35 624–631 Occurrence Handle1322850 Occurrence Handle10.1007/BF00400253 Occurrence Handle1:CAS:528:DyaK3sXnvVCkug%3D%3D
Q Li E Zemel B Miller et al. (2002) ArticleTitleEarly retinal damage in experimental diabetes: electroretinographical and morphological observations Exp Eye Res 74 615–625 Occurrence Handle12076083 Occurrence Handle10.1006/exer.2002.1170 Occurrence Handle1:CAS:528:DC%2BD38Xlt1ylt74%3D
S Takeo-Goto M Doi N Ma R Goto R Semba Y Uji (2002) ArticleTitleImmunohistochemical localization of amino acids in the diabetic retina of Goto-Kakizaki rats Ophthalmic Res 34 139–145 Occurrence Handle12097796 Occurrence Handle10.1159/000063657 Occurrence Handle1:CAS:528:DC%2BD38XltVKksb4%3D
H Takagi GL King LP Aiello (1998) ArticleTitleHypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells Diabetes 47 1480–1488 Occurrence Handle9726238 Occurrence Handle1:CAS:528:DyaK1cXlslSjurw%3D
K Miyamoto Y Ogura H Nishiwaki et al. (1996) ArticleTitleEvaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes Invest Ophthalmol Vis Sci 37 898–905 Occurrence Handle8603874 Occurrence Handle1:STN:280:DyaK287otFCntQ%3D%3D
GA Napper M Kalloniatis (1999) ArticleTitleNeurochemical changes following postmortem ischemia in the rat retina Vis Neurosci 16 1169–1180 Occurrence Handle10614596 Occurrence Handle10.1017/S0952523899166161 Occurrence Handle1:STN:280:DC%2BD3c%2FotVagsQ%3D%3D
N Kobayashi S Ishiguro H Tomita S Nishikawa M Tamai (1999) ArticleTitleChanges of GABA metabolic enzymes in acute retinal ischemia Exp Eye Res 69 91–96 Occurrence Handle10375453 Occurrence Handle10.1006/exer.1999.0681 Occurrence Handle1:CAS:528:DyaK1MXjvVOnsL8%3D
GA Napper MJ Pianta M Kalloniatis (2001) ArticleTitleLocalization of amino acid neurotransmitters following in vitro ischemia and anoxia in the rat retina Vis Neurosci 18 413–427 Occurrence Handle11497418 Occurrence Handle10.1017/S0952523801183082 Occurrence Handle1:STN:280:DC%2BD3MvltFClsg%3D%3D
K Biro J Palhalmi AJ Toth T Kukorelli G Juhasz (1998) ArticleTitleBimoclomol improves early electrophysiological signs of retinopathy in diabetic rats Neuroreport 9 2029–2033 Occurrence Handle9674588 Occurrence Handle1:STN:280:DyaK1czjslentw%3D%3D Occurrence Handle10.1097/00001756-199806220-00022
K Maeda Y Segawa H Asai et al. (1997) ArticleTitleChange in electroretinograms of spontaneously diabetic rats Nihon Ganka Kiyo (Folia Ophthalmol Jpn) 48 851–854
I Kiyosawa M Aoki T Imamura et al. (1994) ArticleTitleAge-related changes in the visual function of WBN/Kob rats Exp Anim 43 357–367 Occurrence Handle1:STN:280:DyaK2M%2FhtVehsQ%3D%3D
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Matsubara, H., Kuze, M., Sasoh, M. et al. Time-Dependent Course of Electroretinograms in the Spontaneous Diabetic Goto-Kakizaki Rat. Jpn J Ophthalmol 50, 211–216 (2006). https://doi.org/10.1007/s10384-005-0315-8
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DOI: https://doi.org/10.1007/s10384-005-0315-8