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Anti-Saccharomyces cerevisiae Antibody in Intestinal Behçet’s Disease Patients: Relation to Clinical Course

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Diseases of the Colon & Rectum

Purpose

This study was designed to assess anti-Saccharomyces cerevisiae antibody positive rate in Behçet’s disease and intestinal Behçet’s disease and to evaluate whether anti-Saccharomyces cerevisiae antibody expression is associated with clinical findings at diagnosis and clinical course of intestinal Behçet’s disease.

Methods

One hundred six patients with intestinal Behçet’s disease, 30 patients with Behçet’s disease, and 45 healthy control subjects were included. Anti-Saccharomyces cerevisiae antibody was detected by indirect immunofluorescence assay. According to anti-Saccharomyces cerevisiae antibody expression, the various parameters at diagnosis, cumulative relapse rates, and cumulative probabilities of operation were analyzed.

Results

Anti-Saccharomyces cerevisiae antibody positive rate was 44.3 percent in intestinal Behçet’s disease, 3.3 percent in Behçet’s disease, and 8.8 percent in healthy control subjects. In patients with intestinal Behçet’s disease, age, gender, distribution of Behçet’s disease subtype, symptoms, laboratory tests, and colonoscopic findings at diagnosis were not different according to anti-Saccharomyces cerevisiae antibody expression. Cumulative probability of a first operation was significantly higher in anti-Saccharomyces cerevisiae antibody (+) intestinal Behçet’s disease than in anti-Saccharomyces cerevisiae antibody (−) intestinal Behçet’s disease: 44.8 and 17.2 percent at one year, and 53 and 24.3 percent at two years after diagnosis, respectively (P = 0.006). The number of patients who underwent two or more operations was higher in anti-Saccharomyces cerevisiae antibody (+) intestinal Behçet’s disease than in anti-Saccharomyces cerevisiae antibody (−) intestinal Behçet’s disease (21.3 vs. 8.5 percent). The cumulative relapse rates were not different between the two groups.

Conclusions

Anti-Saccharomyces cerevisiae antibody positive rate was 44.3 percent in intestinal Behçet’s disease. Clinical findings at diagnosis and cumulative relapse rates of intestinal Behçet’s disease were not found to be associated with anti-Saccharomyces cerevisiae antibody expression. However, patients with anti-Saccharomyces cerevisiae antibody (+) intestinal Behçet’s disease were more likely to receive surgical treatment.

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Authors and Affiliations

  1. Department of Internal Medicine, Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

    Chang Hwan Choi M.D., Tae Il Kim M.D., Byung Chang Kim M.D., Sung Jae Shin M.D., Sang Kil Lee M.D. & Won Ho Kim M.D.

  2. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea

    Hyon Suk Kim M.D.

  3. Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, Seoul, 120–752, Korea

    Won Ho Kim M.D.

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  1. Chang Hwan Choi M.D.
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  2. Tae Il Kim M.D.
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Correspondence to Won Ho Kim M.D..

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Supported by a faculty research grant of Yonsei University College of Medicine for 2003 (6-2003-0013).

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Choi, C.H., Kim, T.I., Kim, B.C. et al. Anti-Saccharomyces cerevisiae Antibody in Intestinal Behçet’s Disease Patients: Relation to Clinical Course. Dis Colon Rectum 49, 1849–1859 (2006). https://doi.org/10.1007/s10350-006-0706-z

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