Abstract
PURPOSE: Age is reported as a risk factor for carcinogenesis, even though age can affect cancer behavior both positively and negatively. Young patients with colorectal cancer reveal different tumor characteristics than average-age and older-age groups, although few studies report the influence of age among the entire range of patient ages. The influence of age on clinicopathologic characteristics of sporadic colorectal cancer was analyzed. Whether an age group with distinct tumor characteristics was present was determined. METHODS: A total of 5,436 patients who underwent colectomy in a single institute within a seven-year period were studied. Data on clinical and histopathologic features of colorectal cancer were collected from the cancer registry and medical records. These characteristics were analyzed according to ten-year age groups. RESULTS: Eighty-three patients (1.6 percent) were 30 years of age or younger, whereas 285 (5.5 percent) were 31 to 40 years of age. Most patients (74.6 percent) were 51 to 80 years of age. The proportion of localized tumors (Dukes A and Dukes B) significantly increased as age increased, from 31.3 percent in the 30 years or younger age group to 49 percent in the 80 years or older group (P < 0.001). The proportion of poorly differentiated tumors tended to decreased as age increased (from 16.9 percent in the 30 years or younger group to 6.2 percent in the 80 years or older group; P = 0.009). A similar trend in the proportion of mucin-producing tumors was also observed (36 percent in the younger group vs. 7.5 percent in the older group; P < 0.001). There was no significantly different distribution of tumor locations among the different age groups. CONCLUSIONS: Age appears to favorably influence the clinicopathological characteristics of sporadic colorectal cancer. As age increased, the characteristics of tumor stage at diagnosis, tumor differentiation, and mucin production improved.
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References
J Campisi (1997) ArticleTitleAging and cancer J Am Ger Soc 45 482–490
HA Preti F Cabanillas M Talpaz SL Tucker JF Seymour R Kurzrock (1997) ArticleTitlePrognostic value of serum interleukin-6 in diffuse large-cell lymphoma Ann Intern Med 127 186–194
SD Heys TJ O’Hamrahan J Brittenden et al. (1994) ArticleTitleColorectal cancer in young patients Eur J Surg Oncol 20 225–231
AY Bedikian H Kantarjian RS Nelson et al. (1981) ArticleTitleColorectal cancer in young adults South Med J 74 920–924
R Fante P Benatti C di Gregoria et al. (1997) ArticleTitleColorectal carcinoma in different age groups Am J Gastroenterol 92 1505–1509
E Mitry AM Benhamiche JL Jouve F Clinard C Finn-Faivre J Faivre (2001) ArticleTitleColorectal adenocarcinoma in patients under 45 years of age Dis Colon Rectum 44 380–387
PM Griffin JM Liff RS Greenberg et al. (1991) ArticleTitleAdenocarcinomas of the colon and rectum in persons under 40 years old. A population-based study Gastroenterology 100 1033–1040
J Domergue M Ismail C Astre et al. (1988) ArticleTitleColorectal carcinoma in patients younger than 40 years of age Cancer 61 835–840
WH Isbister J Fraser (1990) ArticleTitleLarge-bowel cancer in the young Dis Colon Rectum 33 363–366
SE Mils MS Allen SuffixJr (1979) ArticleTitleColorectal carcinoma in the first three decades of life Am J Surg Pathol 3 443–448
U Öhman (1982) ArticleTitleColorectal carcinoma in patients less than 40 years of age Dis Colon Rectum 25 209–214
M Adloff JP Arnaud M Schloegel D Thibaud R Bergamaschi (1986) ArticleTitleColorectal cancer in patients under 40 years of age Dis Colon Rectum 29 322–325
C Smith JA Butler (1989) ArticleTitleColorectal cancer in patients younger than 40 years of age Dis Colon Rectum 32 843–846
A Behbehani M Sakwa R Ehrlichman et al. (1985) ArticleTitleColorectal carcinoma in patients under age 40 Ann Surg 202 610–614
YF Chung KW Eu D Machin et al. (1998) ArticleTitleYoung age is not a poor prognostic marker in colorectal cancer Br J Surg 85 1255–1259
M Recalde ED Holyoke EG Elias (1974) ArticleTitleCarcinoma of the colon, rectum and anal canal in young patients Surg Gynecol Obstet 139 909–913
HF Vasen JP Mecklin P Meera Khan HT Lynch (1991) ArticleTitleThe international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC) Dis Colon Rectum 34 424–425
VB Astler FA Coller (1954) ArticleTitleThe prognostic significance of direct extension of carcinoma of the colon and rectum Ann Surg 139 846–848
AS Soliman ML Bondy B Levin MR Hamza K Ismail S Ismail (1997) ArticleTitleColorectal cancer in Egyptian patients under 40 years of age Int J Cancer 71 26–30
JP Mecklin P Sipponen HJ Jarvinen (1986) ArticleTitleHistopathology of colorectal carcinomas and adenomas in cancer family syndrome Dis Colon Rectum 29 849–853
B Liu SM Farrington GM Petersen et al. (1995) ArticleTitleGenetic instability occurs in the majority of young patients with colorectal cancer Nat Med 4 348–352
VD Rajiv PL Michael BP Philip (2000) ArticleTitleGenetic and phenotypic correlates of colorectal cancer in young patients N Engl J Med 342 137–138
L Messerini F Vitelli LR De Vitis et al. (1997) ArticleTitleMicrosatellite instability in sporadic mucinous colorectal carcinomas J Pathol 182 380–384
KR Jerome DL Barnd KM Bendt et al. (1991) ArticleTitleCytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells Cancer Res 51 2908–2916
EK Millar J Beretov M Sarris et al. (2001) ArticleTitleMucinous differentiation in colonic adenocarcinoma is associated with a reduction in tumor-infiltrating lymphocytes Eur J Surg Oncol 27 273–277
K Kontani O Taguchi T Narita et al. (2001) ArticleTitleModulation of MUC1 mucin as an escape mechanism of breast cancer cell from autologous cytotoxic T-lymphocytes Br J Cancer 84 1258–1264
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Chiang, JM., Chen, MC., Changchien, C.R. et al. Favorable Influence of Age on Tumor Characteristics of Sporadic Colorectal Adenocarcinoma. Dis Colon Rectum 46, 904–910 (2003). https://doi.org/10.1007/s10350-004-6683-1
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DOI: https://doi.org/10.1007/s10350-004-6683-1