Abstract
Objective
Self-gating (SG) is a method to record cardiac movement during MR imaging. It uses information from an additional short, non-spatially encoded data acquisition. This usually lengthens TE and increases the sensitivity to flow artifacts. A new flow compensation scheme optimized for self-gating sequences is introduced that has very little or no time penalty over self-gating sequences without flow compensation.
Materials and methods
Three variants of a self-gated 2D spoiled gradient echo or fast low angle shot (FLASH) sequence were implemented: without (noFC), with a conventional, serial (cFC), and with a new, time-efficient flow compensation (sFC). In experiments on volunteers and small animals, the sequence variants were compared with regard to the SG signal and the flow artifacts in the images.
Results
Both cFC and sFC reduce flow artifacts in cardiac images. The SG signal of the sFC is more sensitive to physiological motion, so that a cardiac trigger can be extracted more precisely as in cFC. In a typical setting for small animal imaging, sFC technique reduces the echo/repetition time over cFC by about 23%/14%.
Conclusion
The time-efficient sFC technique provides flow-compensated images with cardiac triggering in both volunteers and small animals.
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References
Togawa T, Okai O, Oshima M (1967) Observation of blood flow e.m.f. in externally applied strong magnetic field by surface electrodes. Med Biol Eng 5(2): 169–70
Tenforde TS (2005) Magnetically induced electric fields and currents in the circulatory system. Prog Biophys Mol Biol 87(2–3): 279–288
Keltner JR, Roos MS, Brakeman PR, Budinger TF (1990) Magnetohydrodynamics of blood flow. Magn Reson Med 16: 139–149
Rokey R, Wendt RE, Johnston DL (1988) Monitoring of acutely ill patients during nuclear magnetic-resonance imaging—use of a time-varying filter electrocardiographic gating device to reduce gradient artifacts. Magn Reson Med 6(2): 240–245
Polson M, Barker A, Gardiner S (1982) The effect of rapid rise-time magnetic fields on the ECG of the rat. Clin Phys Physiol Meas 3: 231–234
Shetty AN (1988) Suppression of radiofrequency interference in cardiac gated MRI—a simple design. Magn Reson Med 8(1): 84–88
Damji A, Snyder R, Ellinger D, Witkowski F, Allen P (1988) RF interference suppression in a cardiac synchronization system operating in a high magnetic field NMR imaging system. Magn Reson Imaging 6: 637–640
Wendt RE, Rokey R, Vick W, Johnston DL (1988) Electrocardiographic gating and monitoring in NMR imaging. Magn Reson Imaging 6: 89–95
Fischer EF, Wickline SA, Lorenz CH (1999) Novel real-time R-wave detection algorithm based on the vectorcardiogram for accurate gated magnetic resonance acquisitions. Magn Reson Med 42: 361–370
Kugel H, Bremer C, Puschel M, Fischbach R, Lenzen H, Tombach B, Van Aken H, Heindel W (2003) Hazardous situation in the MR bore: induction in ECG leads causes fire. Eur Radiol 13(4): 690–694
Brau AC, Brittain JH (2006) Generalized self-navigated motion detection technique: preliminary investigation in abdominal imaging. Magn Reson Med 55: 263–270
Crowe ME, Larson AC, Zhang Q, Carr J, White RD, Li D, Simonetti OP (2004) Automated rectilinear self-gated cardiac cine imaging. Magn Reson Med 52(4): 782–788
Nijm GM, Sahakian AV, Swiryn S, Larson AC (2007) Comparison of signal peak algorithms for self-gated cardiac CINE MRI. Comput Cardiol 34: 407–410
Larson AC, White RD, Laub G, McVeigh ER, Li D, Simonetti O (2004) Selfgated cardiac cine MRI. Magn Reson Med 51: 93–102
Hiba B, Richard N, Janier M, Croisille P (2006) Cardiac and respiratory double self-gated cine MRI in the mouse at 7 T. Magn Reson Med 55: 506–513
Pattany PM, Phillips JJ, Chiu LC, Lipcamon JD, Duerk JL, McNally JM, Mohapatra SN (1987) Motion artifact suppression technique (MAST). Comput Assist Tomogr 11(3): 369
Haacke EM, Lenz GW (1987) Improving MR image quality in the presence of motion by using rephasing gradients. Am J Roentgenol 148: 1251–1258
Wendt RE III (1991) Interactive design of motion-compensated gradient waveforms with a personal computer spreadsheet. J Magn Reson Imaging 1(1): 87–92
Wood ML, Henkelman MR (1999) Artifacts: In: Stark DD, Bradley WG (ed) Magnetic resonance imaging(1). St. Louis, Mosby, Chap. 10
Kober F, Iltis I, Cozzone PJ, Bernard M (2004) Cine-MRI assessment of cardiac function in mice anesthetized with ketamine/xylazine and isoflurane. Magn Reson Mater Phy 17: 157–161
Ehman RL, McNamara MT, Pallack M, Hricak H, Higgins CB (1984) Magnetic resonance imaging with respiratory gating: techniques and advantages. Am J Radiol 143: 1175–1182
Mayer D, Zahr NM, Adalsteinsson E, Rutt B, Sullivan EV, Pfefferbaum A (2007) In vivo fiber tracking in the rat brain on a clinical 3T MRI system using a high strength insert gradient coil. Neuroimage 35(3): 1077–1085
Fink C, Kiessling F, Bock M, Lichy MP, Misselwitz B, Peschke P, Fusenig NE, Grobholz R, Delorme S (2003) High-resolution 3D MR angiography of rodent tumors: morphologic characterization of intratumoural vasculature. J Magn Reson Imaging 18: 59–65
Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Konishi J, Togashi K, Brechbiel MW (2001) Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: Reference to pharmacokinetic properties of dendrimer-based MR contrast agents. J Magn Reson Imaging 14: 705–713
Kiessling F, Greschus S, Michy MP, Bock M, Fink C, Vosseler S, Moll J, Mueller MM, Fusenig NE, Traupe H, Semmler W (2004) Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis. Nat Med 10(10): 1133–1138
Franco F, Thomas GD, Giroir B, Bryant D, Bullock MC, Chwialkowski MC, Victor RG, Peshock RM (1999) Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 99: 448–454
Bernstein MA, Shimakawa A, Pelc NJ (1992) Minimizing TE in moment-nulled or flow-encoded two- and three-dimensional gradient-echo imaging. J Magn Reson Imaging 2: 583–588
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Schulz, J., Korn, M., Deimling, M. et al. Flow-compensated self-gating. Magn Reson Mater Phy 21, 307–315 (2008). https://doi.org/10.1007/s10334-008-0131-5
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DOI: https://doi.org/10.1007/s10334-008-0131-5