Abstract
The outer membrane permeability of carbapenems (imipenem [IPM], panipenem [PAPM], meropenem [MEPM], and biapenem [BIPM]) and ceftazidime (CAZ) to Pseudomonas aeruginosa was determined by the Zimmermann and Rosselet method. The permeability coefficients of β-lactams tested at 50 μM concentration of substrates ranged from (0.40 ± 0.10) × 10−6 cm/s for CAZ to (2.33 ± 0.33) × 10−6 cm/s for IPM, indicating that the outer membrane permeability of carbapenems to P. aeruginosa was high in comparison with that of CAZ. In particular, IPM and BIPM showed a higher rate of penetration than MEPM and PAPM.
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Received: November 30, 1998 / Accepted: March 10, 1999
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Iyobe, S., Watanabe, M., Mitsuhashi, S. et al. Estimation of outer membrane permeability of carbapenem antibiotics to Pseudomonas aeruginosa . J Infect Chemother 5, 168–170 (1999). https://doi.org/10.1007/s101560050028
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DOI: https://doi.org/10.1007/s101560050028