Abstract
Stereotactic radiotherapy (SRT) for extracranial tumors has been recently performed to treat lung and liver cancers, and has subsequently been named stereotactic body radiotherapy (SBRT). The advantages of hypofractionated radiotherapy for treating lung tumors are a shortened treatment course that requires fewer trips to the clinic than a conventional program, and the adoption of a smaller irradiated volume allowed by greater setup precision. This treatment is possible because the lung and liver are considered parallel organs at risk. The preliminary clinical results, mostly reported on lung cancer, have been very promising, including a local control rate of more than 90%, and a relatively low complication rate. The final results of a few clinical trials are awaited. SBRT may be useful for the treatment of stage I lung tumors.
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JF Fowler WA Tome JD Fenwick MP Mehta (2004) ArticleTitleA challenge to traditional radiation oncology Int J Radiat Oncol Biol Phys 60 1241–1256 Occurrence Handle15519797 Occurrence Handle10.1016/j.ijrobp.2004.07.691
H Blomgren I Lax H Goeranson et al. (1998) ArticleTitleRadiosurgery for tumors in the body: clinical experience using a new method J Radiosurg 1 63–74 Occurrence Handle10.1023/B:JORA.0000010880.40483.c4
I Lax H Blomgren D Larson et al. (1998) ArticleTitleExtracranial stereotactic radiosurgery of localized target J Radiosurg 1 135–148 Occurrence Handle10.1023/B:JORA.0000010898.87146.2e
Y Negoro Y Nagata T Aoki et al. (2001) ArticleTitleThe effectiveness of an immobilization device in conformal radiotherapy for lung tumor: reduction of respiratory tumor movement and evaluation of daily set-up accuracy Int J Radiat Oncol Biol Phys 50 889–898 Occurrence Handle11429216 Occurrence Handle10.1016/S0360-3016(01)01516-4 Occurrence Handle1:STN:280:DC%2BD3Mznt1KlsA%3D%3D
RJ Yaes P Patel Y Maruyama (1991) ArticleTitleOn using the linear-quadratic model in daily clinical practice Int J Radiat Oncol Biol Phys 20 1353–1362 Occurrence Handle2045309 Occurrence Handle1:STN:280:DyaK3M3lvVWrsg%3D%3D
T Ishimori T Saga Y Nagata et al. (2004) ArticleTitle18F-FDG and 11C-Methionine evaluation of the treatment response of lung cancer after stereotactic radiotherapy Ann Nuclear Med 18 669–674 Occurrence Handle10.1007/BF02985960
M Uematsu A Shioda K Tahara et al. (2001) ArticleTitleComputed tomography-guided frameless stereotactic radiotherapy for stage I non-small-cell lung cancer: a 5-year experience Int J Radiat Oncol Biol Phys 51 666–670 Occurrence Handle11597807 Occurrence Handle10.1016/S0360-3016(01)01703-5 Occurrence Handle1:STN:280:DC%2BD3MrltFGisA%3D%3D
T Arimoto H Usubuchi T Matsuzawa et al. (1998) Small volume multiple non-coplanar arc radiotherapy for tumors of the lung, head & neck and the abdominopelvic region HU Lemke (Eds) CAR′98 Computer assisted radiology and surgery Elsevier Tokyo
R Timmerman L Papiez R McGarry et al. (2003) ArticleTitleExtracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer Chest 124 1946–1955 Occurrence Handle14605072 Occurrence Handle10.1378/chest.124.5.1946
R Onimaru H Shirato S Shimizu et al. (2003) ArticleTitleTolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers Int J Radiat Oncol Biol Phys 56 126–135 Occurrence Handle12694831 Occurrence Handle10.1016/S0360-3016(03)00095-6
J Wulf U Haedinger U Oppitz et al. (2004) ArticleTitleStereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients Int J Radiat Oncol Biol Phys 60 186–196 Occurrence Handle15337555 Occurrence Handle10.1016/j.ijrobp.2004.02.060
S Lee EK Choi HJ Park et al. (2003) ArticleTitleStereotactic body frame based fractionated radiosurgery in the consecutive days for primary and metastatic tumor in the lung Lung Cancer 40 309–315 Occurrence Handle12781430
Y Nagata Y Negoro T Aoki et al. (2005) ArticleTitleClinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiation therapy in four fractions using a stereotactic body frame Int J Radiat Oncol Biol Phys 63 1427–1431 Occurrence Handle16169670 Occurrence Handle10.1016/j.ijrobp.2005.05.034
H Onishi T Araki H Shirato et al. (2004) ArticleTitleStereotactic hypofractionated high-dose irradiation for stage I non-small cell lung carcinoma Cancer 101 1623–1631 Occurrence Handle15378503 Occurrence Handle10.1002/cncr.20539
Y Nagata Y Matsuo K Takayama et al. (2006) ArticleTitleSurvey of SBRT in Japan Int J Radiat Oncol Biol Phys 66 IssueIDSuppl 1 s150–151
R Timmerman R McGarry C Yiannoutsos et al. (2006) ArticleTitleExcessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer JCO 24 4833–4839 Occurrence Handle10.1200/JCO.2006.07.5937
M Joyner BJ Salter N Papanikolaou M Fuss (2006) ArticleTitleStereotactic body radiation therapy for centrally located lung lesions Acta Oncol 45 802–807 Occurrence Handle16982543 Occurrence Handle10.1080/02841860600915322
P Baumann J Nyman I Lax et al. (2006) ArticleTitleFactors important for efficacy of stereotactic body radiation therapy of medically inoperable stage I lung cancer. A retrospective analysis of patients in the Nordic countries Acta Oncol 45 787–795 Occurrence Handle16982541 Occurrence Handle10.1080/02841860600904862
R Liu JM Buatti TL Howes et al. (2006) ArticleTitleOptimal number of beams for stereotactic body radiotherapy of lung and liver tumors Int J Radiat Oncol Biol Phys 66 906–912 Occurrence Handle16904842
T Kimura K Matsuura Y Murakami et al. (2006) ArticleTitleCT appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: are patients with pulmonary emphysema also candidates for SBRT for lung cancers? Int J Radiat Oncol Biol Phys 66 483–491 Occurrence Handle16904838
KK Herfarth J Debus F Lohr et al. (2000) ArticleTitleStereotactic single dose radiation treatment of tumors in the lung Radiology 217 IssueIDSuppl. 148
RC McGarry L Papiez M Williams et al. (2005) ArticleTitleStereotactic body radiation therapy of early-stage non-small-cell lung cancer: phase I study Int J Radiat Oncol Biol Phys 63 1010–1015 Occurrence Handle16115740 Occurrence Handle10.1016/j.ijrobp.2005.03.073
JJ Beitler EA Badine D El-Savah et al. (2006) ArticleTitleStereotactic body radiation therapy for nonmetastatic lung cancer. An analysis of 75 patients over 5 years Int J Radiat Oncol Biol Phys 65 100–106 Occurrence Handle16517092 Occurrence Handle10.1016/j.ijrobp.2005.11.028
InstitutionalAuthorNameLung Cancer Study Group (1995) ArticleTitleRandomized trial of lobectomy versus limited resection for T1N0 non-small cell lung cancer Ann Thorac Surg 60 615–623 Occurrence Handle10.1016/0003-4975(95)00537-U
JD Luketich RJ Ginsberg (1996) Limited resection versus lobectomy for stage I non-small cell lung cancer HI Pass JB Mitchell DH Johnson (Eds) et al. Lung cancer: Principles and Practice Lippincott-Raven Philladelphia 561–566
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Nagata, Y., Matsuo, Y., Takayama, K. et al. Current status of stereotactic body radiotherapy for lung cancer. Int J Clin Oncol 12, 3–7 (2007). https://doi.org/10.1007/s10147-006-0646-6
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DOI: https://doi.org/10.1007/s10147-006-0646-6