Abstract
We report a case of squamous cell carcinoma (SCC) of the bladder treated successfully with intraarterial chemotherapy using nedaplatin. A 75-year-old woman was admitted to our hospital in March 2004 with gross hematuria. Cystoscopic examination showed tumors on the anterior bladder wall. Computed tomography (CT) scans and magnetic resonance imaging (MRI) revealed extravesical invasion of the tumors, and a clinical diagnosis of T3bN0M0 was made. Transurethral biopsy was performed, and histopathological examination revealed SCC, grade 2–3, invasive. The patient received a new combined chemotherapy, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine. After two courses of the chemotherapy, CT scans and MRI demonstrated no tumor in the bladder. Transurethral bladder-wall biopsy was performed in November 2004, and histopathological examination of the specimen revealed no definite tumors. The patient is alive without evidence of disease more than 1 year after the chemotherapy.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
S Naito T Kuroiwa T Ueda et al. (1995) ArticleTitleCombination chemotherapy with intra-arterial cisplatin and doxorubicin plus intravenous methotrexate and vincristine for locally advanced cancer J Urol 154 1704–1709 Occurrence Handle7563327 Occurrence Handle1:STN:280:BymD3cfjvFA%3D Occurrence Handle10.1016/S0022-5347(01)66759-4
K Tashiro T Machida Y Ohishi (1980) ArticleTitleClinical study on 22 cases of squamous call carcinoma of urinary bladder Rinsho Hinyokika 34 1069–1072
V Serretta G Pomara F Piazza et al. (2000) ArticleTitlePure squamous cell carcinoma of the bladder in Western countries Eur Urol 37 85–89 Occurrence Handle10671791 Occurrence Handle1:STN:280:DC%2BD3c7jvVSgsQ%3D%3D Occurrence Handle10.1159/000020105
N Hayashi K Asano A Furuta et al. (2004) ArticleTitleInvasive squamous call carcinoma of the bladder: report of 18 cases and review of literature Jpn J Urol 95 711–717
T Hayakawa T Matsuda (1997) ArticleTitleIntra-arterial chemotherapy combined with radiation therapy for squamous cell carcinoma of the bladder: a case report Nishinihon J Urol 59 533–535
F Manabe Y Ami A Iwasaki et al. (1989) ArticleTitleStatistical observations of the squamous cell carcinoma of the bladder Jpn J Urol Surg 2 845–848
K Sugiura Y Miyauchi A Uda et al. (2000) ArticleTitleExperience of total cystectomy after radiation therapy combined with intra-arterial chemotherapy for squamous call carcinoma of the urinary bladder: a case report Rinsho Hinyokika 54 63–65
H Akaza M Togashi Y Nishio et al. (1992) ArticleTitlePhase II study of cis-diammine (glycolate) platinum, 254-S, in patients with advanced germ-cell testicular cancer, prostatic cancer, and transitional-cell carcinoma of the urinary tract Cancer Chemother Pharmacol 31 187–192 Occurrence Handle1334448 Occurrence Handle1:STN:280:ByyD1MbmslQ%3D Occurrence Handle10.1007/BF00685546
Y Inuyama H Miyake M Horiuchi et al. (1992) ArticleTitleA late phase II clinical study of Cis-diammine glycolato platinum, 254-S, for head and neck cancer Jpn J Cancer Chemother 19 871–877 Occurrence Handle1:STN:280:By2B1MnotVE%3D
T Taguchi A Wakui K Nabeya et al. (1992) ArticleTitleA phase II clinical study of Cis-diammine glycolato platinum, 254-S, for gastro-intestinal cancers Jpn J Cancer Chemother 19 483–488 Occurrence Handle1:STN:280:By2B3Mvps1c%3D
T Kato H Nishimura M Yakushiji et al. (1992) ArticleTitleA phase II study of 254-S (Cis-diammine glycolato platinum) for gynecological cancer Jpn J Cancer Chemother 19 695–701 Occurrence Handle1:STN:280:By2B2MrjsFM%3D
M Takamichi K Makoto (2004) ArticleTitlePharmacodynamics of tongue tissue and plasma after intraarterial infusion of cis-diammine glycolato platinum (CDGP) Nippon Jibiinkoka Gakkai Kaiho 107 990–997
M Inuyama H Miyake M Horiuchi et al. (1990) ArticleTitlePhase II study of (glycolate-O,O)-diammineplatinum (II), a novel platinum complex, in the treatment of non-small cell lung cancer Cancer Chemother Pharmacol 26 393–396 Occurrence Handle10.1007/BF02994087
S Suzuki N Shinohara T Harabayashi et al. (2004) ArticleTitlePaclitaxel, ifosfamide, nedaplatin (TIN) for patients with metastatic urothelial cancer Jpn J Cancer Chemother 31 561–565
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Shigehara, K., Kitagawa, Y., Nakashima, T. et al. Squamous cell carcinoma of the bladder: a patient treated successfully with a new combined chemotherapy regimen, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine. Int J Clin Oncol 11, 329–331 (2006). https://doi.org/10.1007/s10147-006-0571-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10147-006-0571-8