Abstract
Since 1985, when gastric-type well-differentiated adenocarcinomas were demonstrated in hyperplastic polyps of the stomach, we have studied phenotypic expression in gastrointestinal epithelial lesions. The recent discovery of MUC genes coding core proteins of mucin has improved research on the phenotypic expression of gastrointestinal neoplasms. The disease entity of gastric-type well-differentiated adenocarcinoma has recently been accepted, especially in Japan and Europe. This entity has often become a clinicopathological subject of discussion, because its biological behavior is possibly highly malignant, in spite of the difficulty in making endoscopic and histopathological diagnoses. Even under these circumstances, the term “gastric adenoma” usually means flat adenoma of the intestinal type. Gastric-type adenomas have been regarded as exceptional until recently. Although gastric-type adenomas could theoretically be classified into foveolar type and pyloric-gland type, foveolar-type adenoma is, in practice, difficult to distinguish from gastric-foveolar-type adenocarcinoma. In 2003, we first reported systematic clinicopathological analyses of pyloric gland adenoma, demonstrating its unstable and precancerous nature. In this article, we review and discuss the clinicopathological and molecular pathological aspects of gastric-type well-differentiated adenocarcinomas and pyloric gland adenomas, mainly based on our published and unpublished data.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
P Laurén (1965) ArticleTitleThe two main histological types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma Acta Pathol Microbiol Scand 82 308–14
K Nakamura H Sugano K Takagi (1968) ArticleTitleCarcinomas of the stomach: its histogenesis and histological appearances Gann 59 251–8 Occurrence Handle5726267 Occurrence Handle1:STN:280:CCaD287ps1U%3D
H Sugano K Nakamura Y Kato (1982) ArticleTitlePathological studies on human gastric cancer Acta Pathol Jpn 32 329–47 Occurrence Handle6765003
J Parsonnet D Vandersteen J Goates RK Sibley J Pritikin Y Chang (1991) ArticleTitle Helicobacter pylori infection in intestinal-, and diffuse-type gastric adenocarcinomas J Natl Cancer Inst 83 640–3 Occurrence Handle2023282 Occurrence Handle1:STN:280:By6B3MfitVE%3D
P Correa (1995) ArticleTitle Helicobacter pylori and gastric carcinogenesis Am J Surg Pathol 19 IssueIDSuppl 1 S37–43 Occurrence Handle7762738
CA Reis L David P Correa F Carneiro C de Bolos E Garcia et al. (1999) ArticleTitleIntestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression Cancer Res 59 1003–7 Occurrence Handle10070955 Occurrence Handle1:CAS:528:DyaK1MXhslemtLc%3D
S Tsukashita R Kushima M Bamba H Sugihara T Hattori (2001) ArticleTitle MUC gene expression and histogenesis of adenocarcinoma of the stomach Int J Cancer 94 166–70 Occurrence Handle11668493 Occurrence Handle1:CAS:528:DC%2BD3MXntVGlu70%3D Occurrence Handle10.1002/ijc.1460
H Shiroshita H Watanabe Y Ajioka G Watanabe K Nishikura S Kitano (2004) ArticleTitleRe-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains Pathol Int 54 311–21 Occurrence Handle15086835 Occurrence Handle1:CAS:528:DC%2BD2cXltlGjs7c%3D Occurrence Handle10.1111/j.1440-1827.2004.01625.x
I Oda T Gotoda N Hasuike H Hamanaka T Eguchi S Minami et al. (2003) ArticleTitleEndoscopic features of differentiated-type early gastric carcinoma with gastric mucin phenotype (in Japanese) Stomach Intestine 38 684–92
R Kushima K Mukaisho S Tsukashita M Vieth M Stolte T Hattori et al. (2003) ArticleTitleMolecular biological characteristics of early stomach adenocarcinoma of the completely gastric phenotype revealed by laser capture microdissectin and comparative genomic hybridization (in Japanese) Stomach Intestine 38 707–21
F Borchard (2000) ArticleTitleFormen und Nomenklatur der gastrointestinalen Epithelexpansion: Was ist Invasion? Verh Dtsch Ges Pathol 84 50–61 Occurrence Handle11217449 Occurrence Handle1:STN:280:DC%2BD3M7ptlGmtQ%3D%3D
T Lesuffleur A Zweibaum FX Real (1994) ArticleTitleMucins in normal and neoplastic human gastrointestinal tissues Crit Rev Oncol Hematol 17 153–80 Occurrence Handle7865137 Occurrence Handle1:STN:280:ByqC28bislw%3D
SJ Williams DH Wreschner M Tran HJ Eyre GR Sutherland MA McGuckin (2001) ArticleTitleMuc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells J Biol Chem 25 18 327–36
BW Yin A Dnistrian KO Lloyd (2002) ArticleTitleOvarian cancer antigen CA125 is encoded by the MUC16 mucin gene Int J Cancer 98 737–40 Occurrence Handle11920644 Occurrence Handle1:CAS:528:DC%2BD38Xis1Wru7o%3D Occurrence Handle10.1002/ijc.10250
GG McIntosh AJ Lodge P Watson AG Hall K Wood JJ Anderson et al. (1999) ArticleTitleNCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissue Am J Pathol 154 77–82 Occurrence Handle9916921 Occurrence Handle1:CAS:528:DyaK1MXnsFCqtQ%3D%3D
A Kabashima T Yao K Sugimachi M Tsuneyoshi (2002) ArticleTitleRelationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas Hum Pathol 33 80–6 Occurrence Handle11823976 Occurrence Handle10.1053/hupa.2002.30182
Y Kato H Sugano J Wada K Nakamura (1978) ArticleTitleHistogenesis of the cardiac carcinoma (adenocarcinoma) in comparison with that of the antral carcinoma (in Japanese) Stomach Intestine 13 1509–15
T Hattori (1985) ArticleTitleMorphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach J Clin Pathol 38 622–30 Occurrence Handle4008664 Occurrence Handle1:STN:280:DyaL2M3jsV2ltA%3D%3D
S Ishiguro (1987) ArticleTitleHistological significance of foveolar type tubular adenocarcinoma of the stomach. Its histogenesis and relationship to undifferentiated carcinoma (in Japanese) Osaka Med J 39 507–15
F Borchard KL Hengels (1988) ArticleTitleSind alle drüsenbildenden Magenkazinome intestinale differenziert? Kritische Bemerkungen zur Lurenschen Klassifikation Verh Dtsch Ges Pathol 72 614
M Tatematsu M Ichinose K Miki R Hasegawa T Kato N Ito (1990) ArticleTitleGastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry Acta Pathol Jpn 40 494–504 Occurrence Handle2220396 Occurrence Handle1:STN:280:By6D383gt1w%3D
R Kushima T Hattori (1993) ArticleTitleHistogenesis and characteristics of gastric-type adenocarcinomas in the stomach J Cancer Res Clin Oncol 120 103–11 Occurrence Handle7903667 Occurrence Handle1:STN:280:ByuD1Mrmt1U%3D Occurrence Handle10.1007/BF01200733
H Watanabe N Kato T Fuchigami T Sato M Iwafuchi Y Ajioka et al. (1992) ArticleTitleNatural history of gastric carcinoma from analysis of microcarcinoma (in Japanese) Stomach Intestine 27 59–67
M Nokubi K Kawanowa H Kawata K Hanatsuka Y Hosoya (2004) ArticleTitleExtremely well-differentiated adenocarcinoma of the gastric cardia: a unique case with columnar cells and laminated stones Pathol Int 54 854–60 Occurrence Handle15533229 Occurrence Handle10.1111/j.1440-1827.2004.01769.x
K Yokoyama T Hattori (1997) ArticleTitleCharacteristics and development of stump cancers of the stomach (in Japanese) Nippon Shokakibyo Gakkai Zasshi 94 261–7 Occurrence Handle9136582
T Yao D Yoshimura M Tsuneyosi N Nakamura M Hirahashi N Matsui et al. (2004) ArticleTitleClinicopathological features and histogenesis of remnant gastric cancer (in Japanese) Stomach Intestine 39 997–1008
N Matsui T Yao K Akazawa H Nawata M Tsuneyoshi (2001) ArticleTitleDifferent characteristics of carcinoma in the gastric remnant: histochemical and immunohistochemical studies Oncol Rep 8 17–26 Occurrence Handle11115563 Occurrence Handle1:CAS:528:DC%2BD3MXjsFaksQ%3D%3D
F Borchard (2001) ArticleTitleChemisch-reaktive Gastritis Pathologe 22 44–55 Occurrence Handle11225445 Occurrence Handle1:STN:280:DC%2BD3M7otFektg%3D%3D Occurrence Handle10.1007/s002920000443
Y Tajima Y Nakanishi T Yoshino A Kokawa M Kusano T Shimoda (2001) ArticleTitleClinicopathological study of early adenocarcinoma of the gastric cardia: comparison with early adenocarcinoma of the distal stomach and esophagus Oncology 61 1–9 Occurrence Handle11474241 Occurrence Handle1:STN:280:DC%2BD3MvislKjug%3D%3D Occurrence Handle10.1159/000055345
SC Abraham EA Montgomery VK Singh JH Yardley TT Wu (2002) ArticleTitleGastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology Am J Surg Pathol 26 1276–85 Occurrence Handle12360042 Occurrence Handle10.1097/00000478-200210000-00004
SC Abraham SJ Park JH Lee L Mugartegui TT Wu (2003) ArticleTitleGenetic alterations in gastric adenomas of intestinal and foveolar phenotypes Mod Pathol 16 786–95 Occurrence Handle12920223 Occurrence Handle10.1097/01.MP.0000080349.37658.5E
F Borchard A Ghanei U Koldovsky KJ Henges Bückmann FW Gastrale (1990) ArticleTitleDifferenzierung in Adenomen der Magenschleimhaut. Immunohistochemische und elektronenmikroskopische Untersuchungen Verh Dtsch Ges Pathol 74 528
H Watanabe JR Jass LH Sobin (1990) Histological typing of oesophageal and gastric tumours Springer Berlin Heidelberg New York Tokyo
R Kushima HJ Rüthlein M Stolte M Bamba T Hattori F Borchard (1999) ArticleTitle“Pyloric gland-type adenoma” arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type Virchows Arch 435 452–7 Occurrence Handle10526011 Occurrence Handle1:STN:280:DyaK1MvlslWksA%3D%3D Occurrence Handle10.1007/s004280050425
N Kato S Akiyama T Motoyama (2002) ArticleTitlePyloric gland-type tubular adenoma superimposed on intraductal papillary mucinous tumor of the pancreas. Pyloric gland adenoma of the pancreas Virchows Arch 440 205–8 Occurrence Handle11964052 Occurrence Handle10.1007/s004280100535
K Takei H Watanabe T Itoi T Saito (1996) ArticleTitlep53 and Ki-67 immunoreactivity and nuclear morphometry of “carcinoma-in-adenoma” and adenoma of the gall-bladder Pathol Int 46 908–17 Occurrence Handle8970203 Occurrence Handle1:STN:280:ByiC38rgvF0%3D Occurrence Handle10.1111/j.1440-1827.1996.tb03569.x
R Kushima W Remmele M Stolte F Borchard (1996) ArticleTitlePyloric gland type adenoma of the gallbladder with squamoid spindle cell metaplasia Pathol Res Pract 192 963–9 Occurrence Handle8950764 Occurrence Handle1:STN:280:ByiC3cfhtFA%3D
M Vieth R Kushima F Borchard M Stolte (2003) ArticleTitlePyloric gland adenoma: a clinico-pathological analysis of 90 cases Virchows Arch 442 317–21 Occurrence Handle12715167 Occurrence Handle1:STN:280:DC%2BD3s7psFKquw%3D%3D
R Kushima K Mukaisho M Vieth F Borchard M Stolte T Hattori (2003) ArticleTitlePyloric-gland-type adenomas of the stomach (in Japanese) Stomach Intestine 38 1377–87
Michal M, Curik R, Matler K, Benes Z. Regarding the paper by Vieth et al. Virchows Arch 442/4:317–321. Virchows Arch 2003;443:589–90
R Kushima M Vieth K Mukaisho T Hattori F Borchard M Stolte et al. (2005) ArticleTitlePyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation Virchows Arch 446 537–41 Occurrence Handle15838649 Occurrence Handle1:CAS:528:DC%2BD2MXksl2gsrk%3D Occurrence Handle10.1007/s00428-004-1185-z
M Vieth R Kushima JP de Jonge F Borchard F Oellig M Stolte (2005) ArticleTitleAdenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum Virchows Arch 446 542–5 Occurrence Handle15838648 Occurrence Handle1:STN:280:DC%2BD2MzptFerug%3D%3D Occurrence Handle10.1007/s00428-005-1242-2
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kushima, R., Vieth, M., Borchard, F. et al. Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach. Gastric Cancer 9, 177–184 (2006). https://doi.org/10.1007/s10120-006-0381-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10120-006-0381-8