Abstract.
Relative regional blood flow of basal ganglia was studied by means of perfusion-weighted dynamic susceptibility (DSC) MRI. Parkinson's disease (PD) patients showed a significant inter-hemispheric asymmetry due to a higher perfusion in the more affected side, while normal subjects did not. PD exhibited an abnormal “asymmetry index” in the measured nuclei. A second DSC-MRI examination performed after subcutaneous apomorphine administration did not show any significant asymmetry in PD patients. DSC-MRI of basal ganglia confirms the asymmetry observed in PET studies of PD patients, suggesting that this method is a promising and low-cost technique in neurodegenerative diseases.
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Correspondence to P. Stanzione
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Brusa, L., Bassi, A., Pierantozzi, M. et al. Perfusion-weighted dynamic susceptibility (DSC) MRI: basal ganglia hemodynamic changes after apomorphine in Parkinson's disease. Neurol Sci 23 (Suppl 2), s61–s62 (2002). https://doi.org/10.1007/s100720200070
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DOI: https://doi.org/10.1007/s100720200070