Abstract
The Multiple Sclerosis Database Network (MSDN) is the first Italian multiple sclerosis (MS) registry. The preliminary results on the MSDN cohort demonstrated that the risk of disability progression, in a sample of 2090 MS patients, was reduced by about four- to five-fold in patients exposed to IFNβ for more than 4 years compared with patients exposed for up to 2 years. More recent results showed, in a subset of 1170 relapsing-remitting MS patients, of whom 918 were treated with IFNβ and 252 were untreated, that IFNβ-treated patients had a differential reduction in EDSS score change of –0.055 for each year of follow-up in comparison with the untreated group. These results provide significant information on the effectiveness of IFNβ treatment on long-term disability progression in MS.
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Trojano, M., Paolicelli, D., Lepore, V. et al. Italian Multiple Sclerosis Database Network. Neurol Sci 27 (Suppl 5), s358–s361 (2006). https://doi.org/10.1007/s10072-006-0694-8
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DOI: https://doi.org/10.1007/s10072-006-0694-8