Abstract.
In 22 patients with idiopathic Parkinson’s disease we observed a sudden worsening of motor symptoms and severe akinesia during hospitalization because of infectious diseases, bone fractures, surgery for gastrointestinal tract diseases, and iatrogenic causes. Of these patients, 12 recovered completely, 6 had a partial recovery, and 4 died. Treatments included subcutaneous apomorphine/lisuride infusion and dantreolene (with a creatine phosphokinase level higher than 200 IU). In all patients a definite refractoriness to therapy was shown with a transient lack of response to apomorphine.
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Thomas, A., Iacono, D., Luciano, A.L. et al. Acute akinesia or akinetic crisis in Parkinson’s disease. Neurol Sci 24, 219–220 (2003). https://doi.org/10.1007/s10072-003-0139-6
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DOI: https://doi.org/10.1007/s10072-003-0139-6