Abstract
Introduction
In this invited commentary, we aim to quantify and explain the variation between, and also within, developed healthcare systems (using the UK as an example) and low- to middle-income countries (LMICs). Rather than including complex cases, we have looked only at ‘uncomplicated’ primary unilateral inguinal hernias, an area where limited variation may be identified.
Methods
Data were obtained from Hospital Episode Statistics and structured surveys in the United Kingdom and in low- and middle-income countries.
Conclusion
There is widespread variation in the repair of ‘uncomplicated’ primary inguinal hernias worldwide and within developed healthcare systems.
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Introduction
Of the 20-plus million Inguinal Hernia (IH) repairs carried out annually, a competent general surgeon should be able to perform a simple, cost-effective, durable and low-complication operation [1]. In developed healthcare systems, during the last 30–40 years, there has been a shift from suture/tissue repairs to open and laparoscopic mesh repair, and more recently in advanced healthcare systems, an emerging era of robotics. Synthetic mesh repairs have become the norm and are now the preferred technique in high-resource settings. They have demonstrated superiority over most conventional non-mesh procedures, due to their lower recurrence rates [2,3,4]. More recently, concerns about mesh inguinodynia have stimulated debate over whether there should be a more prominent role for pure tissue repairs such as the Shouldice operation, which unlike many suture repair techniques, has excellent outcomes in a cohort study [5]. Furthermore, we have seen in some countries the emergence of specialist hernia centres, where tailored treatment may be offered [6].
Epidemiology on inguinal hernia is limited, from both the developed world and particularly from low- to middle-income countries (LMICs). Inguinal hernia incidence (measure of probability of inguinal hernia occurrence in a population within a specified time) is difficult to firmly establish although it seems unlikely that incidence varies much between countries. In contradiction, inguinal hernia prevalence (population proportion with inguinal hernia at a given time) appears to be significantly higher in countries with poor access to healthcare [7,8,9]. The assumption is that most cases go untreated in resource-poor settings. The discrepancy in incidence versus repair rate results in high prevalence. This in turn has a huge economic impact on countries least able to shoulder that burden [10]
A 1996 United Kingdom (UK) study found a lifetime risk of inguinal hernia repair of 27% for men and 3% for women, an immense inguinal hernia disease burden [1]. Data from sub-Saharan Africa paint a very different clinical picture. A 1978 study of rural Ghanaian men estimated that 7.7% had an inguinal hernia [11]. However, a 1969 study showed that the prevalence of inguinal hernia was as high as 30% on Pemba Island in East Africa [12]. A prospective cohort study compared inguinal hernias in Ghana and the UK, and revealed that two-thirds of Ghanaian hernias extended into the scrotum [13]. This was the case in only 7% of UK inguinal hernias. The majority of these were longstanding right-sided indirect hernias. Ghanaian subjects had an average age of 34 years versus 62 years in the UK cohort. Inguinal hernias, occurring in the young, have a major impact on fragile economies. In the Ghanaian study, 64% of subjects experienced daily activity limitations and 16.3% of these individuals were unable to work.
Despite such a high volume of disease and frequency of repair, there remains global disparity in the management of inguinal hernias.
In low-resource settings, where out-of-pocket expenditures are significant and families often cope by borrowing money or selling assets to pay for surgery, mesh is often either unavailable or unaffordable. Most inguinal hernias in these settings are still repaired with the Bassini method (and many modifications) because of the high cost of mesh and the lack of training in mesh repair or pure tissue repair with the Shouldice operation [14, 15].
In this invited commentary, we aim to quantify and explain the variation between, and also within, developed healthcare systems (using the UK as an example) and LMICs. Rather than including complex cases, we have looked only at ‘uncomplicated’ primary unilateral inguinal hernias, an area where limited variation may be identified.
Methods
This is not a comprehensive or an evidence-based study; however, to highlight variation, we explored practice in the United Kingdom using data from Hospital Episode Statistics and also a questionnaire to the Board of the British Hernia Society. Similarly, for rural areas of LMICs, a questionnaire was sent to 100 specialist hernia surgeons, who have worked in 37 low-income countries as volunteer members of ‘Hernia International’.
United Kingdom data (England and Wales only)
Hospital episode statistics (HES) is a database of all hospital admissions, clinic appointments and Emergency Department attendances at NHS hospitals in England. These data were searched using the online database Surgical Workforce Outcome Audit Database (SWORD), which is run by the Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) and the Association of Laparoscopic Surgeons of Great Britain and Ireland (ALS).
Data were extracted for the financial year 2017/2018 and was limited to:
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total number of surgeries for primary inguinal hernias,
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number of tissue repairs, synthetic mesh or natural mesh repairs,
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number of laparoscopic and open repairs.
In addition, a short survey was sent to the eight consultant members of the Board of the British Hernia Society (BHS). The aim was to determine the preferred practice of expert hernia surgeons. See Table 1.
LMICs
A questionnaire was sent to 100 specialist hernia surgeons who had worked as volunteer members of ‘Hernia International’. In total, these consultants have worked in 37 low and middle-income countries (LMICs) worldwide. Questions (see Table 2) were related to the practice of resident (if applicable) surgeons in rural district hospitals in LMICs, in the absence of overseas surgeons.
Results
HES data
In the year 2017/2018, a total of 59,755 primary inguinal hernia repairs were carried out. Synthetic mesh repairs account for 97.6% and suture repairs for only 1.3%. Laparoscopic or endoscopic approaches were used in 23% of repairs, see Table 3.
British Hernia Society Board Survey
Responses were obtained from all eight BHS Board members. One of these responses is excluded because the respondent does not perform any inguinal hernia repairs.
Preferred technique varies between surgeons (Table 4): 37.5% favour the endoscopic totally extraperitoneal (TEP) repair. The majority (5/7) use local anaesthetic only rarely; however, the range is large with one surgeon using local anaesthetic techniques for > 40% of inguinal hernia repairs.
LMICs
One hundred surgeons were surveyed with a 72% response rate. Overall, experience from 37 LIMCs is recorded and results have been interpreted in their nine different regions.
Local resident surgeons in rural district hospitals were rare in all the LMICs surveyed (range 5–50%). This was least frequent in African regions with a range of 5–15% and more frequent in South America and Central Asia (25–50%). Results are shown in Table 5.
Mesh is being used for 0–50% of inguinal hernia repairs, with lowest usage in Africa and the highest in South America. Results are shown in Table 6. In all regions, usage of mesh was higher in the city or university hospital. Laparoscopic techniques are also being used in India, Asia and South America.
Ketamine is available for general anaesthesia in 90% of hospitals in all regions. Gaseous anaesthetic availability is more varied, with a range of 5–50%, and results are shown in Table 7.
Nurse anaesthetists are most common in African Regions, with 25–50% of hospitals using them. In contrast, this is relatively uncommon in India and Asia (0–5%).
Discussion
Our surveys have provided a snapshot of clinical practice in the UK and in rural areas of some LMICs. It demonstrates wide variation in the management of simple unilateral inguinal hernias. Whilst a wide variation might have been expected between LMICs and developed health care systems such as the UK, the variation within each setting is perhaps surprising.
In LMICs, the majority of inguinal hernia repairs are performed using suture repairs under local anaesthetic. In the UK, the vast majority of inguinal hernia repairs utilise mesh. In fact, only 1.3% are performed as a pure tissue repair. Looking at Hospital Episode Statistics data, 77.2% of operations are performed open and 12.8% are performed laparoscopically. Interestingly, the survey of the Board of the British Hernia Society showed wide variation in preferred technique. This variation included the use of open flat mesh, plug and patch, laparoscopic TEP and TAPP. This variation is probably reflects practice in many developed healthcare systems. Swedish data for 2017 report that only 0.8% of all inguinal hernia repairs are tissue repairs without mesh and a total of 33% of inguinal hernia repairs are performed laparoscopically (28% TEP and 5% TAPP). The Danish National Database from 2016 states that more than 95% of inguinal hernia repairs utilised mesh. Laparo-endoscopic surgery use varies from 0 to a maximum of approximately 55% in some high-resource countries. The average use in high-resource countries is largely unknown except for some examples such as Australia (55%) [16], Switzerland (40%) [17], the Netherlands (45%) and Sweden (28%) [18]. Sweden has a national registry with complete coverage. Interesting are the following percentages for the year 2015: Lichtenstein 64%, TEP 25%, TAPP 3%, open pre-peritoneal mesh 3.3%, combined open and pre-peritoneal 2.7%, and tissue repair in 0.8%. The German Herniamed registry which contains data on about 200,000 patients (not complete national coverage, so possibly biased) and contains interesting information confirming that a wide variety of techniques are in use. The percentages over the period 2009–2016 were: TAPP 39%, TEP 25%, Lichtenstein 24%, Plug 3%, Shouldice 2.6%, Gilbert PHS 2.5% and Bassini 0.2%.
Why do we observe such widespread variation? Selecting the optimal technique for inguinal hernia repair is challenging, and influencing factors are both operator and patient specific. The ideal technique should be low risk, and relatively easy to learn. Causes for variation are multifactorial, and training in laparoscopic and endoscopic techniques is time consuming and relies upon availability. Case load needs to be sufficient to maintain competence, so surgeons carrying out smaller volumes may not access such training. In addition, resources for training and equipment are varied, and pressure towards efficiency savings may prohibit the use of laparoscopic techniques.
The fact that so many different repairs are now done strongly suggests that a “best repair method” does not exist. Additionally, large variations in treatments result from cultural differences amongst surgeons, different reimbursement systems and differences in resources and logistical capabilities. Surgeons searching for “best” treatment strategies are challenged by a vast diverse scientific literature, much of which is difficult to interpret and apply to one’s local practice environment.
In LMICs, many inguinal hernias are repaired with open suture repair. Despite good evidence that mesh repairs give lower recurrence rates, LMICs continue to perform significantly more suture repairs [7, 19]. It is notable that surgical interventions have not been prioritised by health budgets. This means that funding is limited. In addition to this general lack of resource, the cost of any mesh used is covered by the patient in most LMICs. Therefore, the decision for mesh or suture repair rests with the patient and decisions are influenced by low incomes and hernia-related difficulty in working. It is notable that in larger city or university hospitals in LMICs, mesh is more frequently used, even when costs are borne by the patient. This may reflect higher incomes in these areas as well as a more evidence-based approach to surgical choice. In some of the higher income areas, laparoscopic techniques are also being used, although not as the inguinal hernia repair technique of choice.
In the UK, most inguinal hernia repairs are performed under general anaesthesia with a minority surgeons operating under local anaesthesia. Use of Ketamine for general anaesthesia is not used in the UK. In contrast, Ketamine is extremely popular in LMICs, with all regions included in the study reporting its availability at 90%. It is probable that economics play a part in this decision. Ketamine is low cost and easily available. It does not necessitate a consultant anaesthetist to be present, allowing the use of nurse anaesthetists, who are more readily available.
Conclusions
There is widespread variation in the repair of ‘uncomplicated’ primary inguinal hernias worldwide and within developed healthcare systems. In LMICs, suture repair is much more prevalent in rural communities and most operations are performed under local anaesthesia. Conversely in developed healthcare systems, there is predominance of mesh repairs under general anaesthesia but there is significant variation in the technique used. We need to strive towards more robust outcome reporting to help identify the optimal techniques and to guide our own practice. As Kirk stated more than 35 years ago, “It is not a particular method of Inguinal Hernia repair that brings success, but the enthusiasm for perfection and the painstaking skill with which is it accomplished” [20]. The technique used is only one factor that affects the overall outcome.
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Estridge, P., Sanders, D.L. & Kingsnorth, A.N. Worldwide hernia repair: variations in the treatment of primary unilateral inguinal hernias in adults in the United Kingdom and in low- and middle-income countries. Hernia 23, 503–507 (2019). https://doi.org/10.1007/s10029-019-01960-6
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DOI: https://doi.org/10.1007/s10029-019-01960-6