Summary.
The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?
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Received August 31, 1999 Accepted September 20, 1999
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Danysz, W., Parsons, C. & Quack, G. NMDA channel blockers: memantine and amino-aklylcyclohexanes –In vivo characterization. Amino Acids 19, 167–172 (2000). https://doi.org/10.1007/s007260070045
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DOI: https://doi.org/10.1007/s007260070045