Summary.
Schizophrenics commonly demonstrate abnormalities in central filtering capability following repetitive sensory stimuli. Such sensory inhibition deficits can be mirrored in rodents following administration of psycho-stimulatory drugs. In the present study, male Sprague-Dawley rats were implanted with brain surface electrodes to record auditory evoked EEG potentials in a paired-stimulus paradigm, using 87 dB clicks delivered 0.5 s apart. Amphetamine (1.83 mg/kg, i.p.) produced the expected loss of sensory inhibition, as defined by an increase in the ratio between test (T) and conditioning (C) amplitudes at N40, a mid-latency peak of the evoked potentials. Also, the 5-HT1A agonist (R)-8-OH-DPAT caused a significant increase in the TC ratio at the highest dose studied (0.5 mg/kg s.c.), while the 5-HT1A antagonist (S)-UH-301 did not significantly affect the TC ratio at any dose studied (0.1–5 mg/kg s.c.). When administered with amphetamine, a lower dose of 8-OH-DPAT (0.1 mg/kg) and the highest dose of UH-301 tested (5 mg/kg, s.c.) were able to reverse the amphetamine-induced increase in TC ratio. The findings suggest that 5-HT1A signaling is involved in sensory inhibition and support the evaluation of 5-HT1A receptor active compounds in conditions with central filtering deficits, such as schizophrenia.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- 8-OH-DPAT:
-
(R)-8-hydroxy-2-(di-n-propyl-amino)tetralin
- UH-301:
-
(S)-5-fluoro-8-hydroxy-2-(di-n-propyl-amino)tetralin
- EEG:
-
electro-encephalography
- s.c.:
-
subcutaneous
- i.p.:
-
intra-peritoneal
- PPI:
-
pre-pulse inhibition
- TC ratio:
-
test amplitude/condition amplitude
- MANOVA:
-
multivariate analysis of variance
- 5-HT:
-
serotonin
- DA:
-
dopamine
- PET:
-
positron emission tomography
- DOI:
-
(2,5-dimethoxy-4-iodoamphetamine
References
GJ Adler J Adler M Schneck B Armbruster (1990a) ArticleTitleInfluence of stimulation parameters on auditory stimulus processing in schizophrenia and major depression: an auditory evoked potential study Acta Psychiat Scand 81 453–458 Occurrence Handle1:STN:280:By%2BB1cbmsFE%3D
LE Adler EM Cawthra KA Donovan JG Harris HT Nagamoto A Olincy MC Waldo (2005) ArticleTitleImproved p50 auditory gating with ondansetron in medicated schizophrenia patients Am J Psychiatry 162 386–388 Occurrence Handle15677607 Occurrence Handle10.1176/appi.ajp.162.2.386
LE Adler GA Gerhardt R Franks N Baker H Nagamoto C Drebing R Freedman (1990b) ArticleTitleSensory physiology and catecholamines in schizophrenia and mania Psychiat Res 31 297–309 Occurrence Handle1:STN:280:DyaK3c3jvFWrsw%3D%3D Occurrence Handle10.1016/0165-1781(90)90099-Q
LE Adler E Pachtman RD Franks M Pecevich MC Waldo R Freedman (1982) ArticleTitleNeurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia Biol Psychiatry 17 639–654 Occurrence Handle7104417 Occurrence Handle1:STN:280:DyaL383lslGrsg%3D%3D
LE Adler K Pang G Gerhardt GM Rose (1988) ArticleTitleModulation of the gating of auditory evoked potentials by norepinephrine: pharmacological evidence obtained using a selective neurotoxin Biol Psychiatry 24 179–190 Occurrence Handle3390498 Occurrence Handle1:CAS:528:DyaL1cXktVWgtr0%3D Occurrence Handle10.1016/0006-3223(88)90273-9
LE Adler G Rose R Freedman (1986) ArticleTitleNeurophysiological studies of sensory gating in rats: Effects of amphetamine, phencyclidine and haloperidol Biol Psychiatry 21 787–798 Occurrence Handle3730461 Occurrence Handle1:CAS:528:DyaL28Xls1CqtL8%3D Occurrence Handle10.1016/0006-3223(86)90244-1
Y Ago Y Koyama A Baba T Matsuda (2003) ArticleTitleRegulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex Neuropharmacology 45 1050–1056 Occurrence Handle14614948 Occurrence Handle1:CAS:528:DC%2BD3sXovVWhtr4%3D Occurrence Handle10.1016/S0028-3908(03)00304-6
S Ahlenius (1989) ArticleTitleAntipsychotic-like properties of the 5-HT1A agonist 8-OH-DPAT in the rat Pharmacol Toxicol 64 3–5 Occurrence Handle2526947 Occurrence Handle1:CAS:528:DyaL1MXht1ymtrk%3D
S Ahlenius I Henriksson O Magnusson P Salmi (1999) ArticleTitleIn vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(−)-UH-301 at rat brain monoamine receptors Eur Neuropsychopharmacol 9 15–19 Occurrence Handle10082223 Occurrence Handle1:CAS:528:DyaK1MXksFCmsw%3D%3D Occurrence Handle10.1016/S0924-977X(97)00100-4
L Arborelius K Chergui S Murase GG Nomikos BB Hook G Chouvet U Hacksell TH Svensson (1993) ArticleTitleThe 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons Naunyn-Schmiedebergs Arch Pharmacol 347 353–362 Occurrence Handle8510763 Occurrence Handle1:CAS:528:DyaK3sXltV2ms7o%3D Occurrence Handle10.1007/BF00165384
L Arborelius BB Hook U Hacksell TH Svensson (1994) ArticleTitleThe 5-HT1A receptor antagonist (S)-UH-301 blocks the (R)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat J Neural Transm 96 179–186 Occurrence Handle1:CAS:528:DyaK2cXmvFamu7s%3D Occurrence Handle10.1007/BF01294785
LE Arvidsson U Hacksell JL Nilsson S Hjorth A Carlsson P Lindberg D Sanchez H Wikstrom (1981) ArticleTitle8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist J Med Chem 24 921–923 Occurrence Handle6460101 Occurrence Handle1:CAS:528:DyaL3MXksFCkt7s%3D Occurrence Handle10.1021/jm00140a002
N Baker LE Adler RD Franks M Waldo S Berry H Nagamoto A Muckle R Freedman (1987) ArticleTitleNeurophysiological assessment of sensory gating in psychiatric inpatients: comparison between schizophrenia and other diagnoses Biol Psychiatry 22 603–617 Occurrence Handle3580435 Occurrence Handle1:STN:280:DyaL2s3hsVeitQ%3D%3D Occurrence Handle10.1016/0006-3223(87)90188-0
RA Bantick JF Deakin PM Grasby (2001) ArticleTitleThe 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics? J Psychopharmacol 15 37–46 Occurrence Handle11277607 Occurrence Handle1:CAS:528:DC%2BD3MXisFylsr8%3D Occurrence Handle10.1177/026988110101500108
RA Bantick AJ Montgomery CJ Bench T Choudhry N Malek PJ McKenna DJ Quested JF Deakin PM Grasby (2004) ArticleTitleA positron emission tomography study of the 5-HT1A receptor in schizophrenia and during clozapine treatment J Psychopharmacol 18 346–354 Occurrence Handle15358978 Occurrence Handle1:CAS:528:DC%2BD2cXpsl2nu7s%3D Occurrence Handle10.1177/026988110401800304
S Benloucif MP Galloway (1991) ArticleTitleFacilitation of dopamine release in vivo by serotonin agonists: studies with mirodialysis Eur J Pharmacol 200 1–8 Occurrence Handle1769366 Occurrence Handle1:CAS:528:DyaK3MXlsFWntb8%3D Occurrence Handle10.1016/0014-2999(91)90658-D
HH Berendsen F Jenck CL Broekkamp (1989) ArticleTitleSelective activation of 5HT1A receptors induces lower lip retraction in the rat Pharmacol Biochem Behav 33 821–827 Occurrence Handle2533357 Occurrence Handle1:CAS:528:DyaK3cXhs1KlsQ%3D%3D Occurrence Handle10.1016/0091-3057(89)90477-2
PC Bickford-Wimer H Nagamoto R Johnson LE Adler M Egan GM Rose R Freedman (1990) ArticleTitleAuditory gating in hippocampal neurons: a model system in the rat Biol Psychiatry 27 183–192 Occurrence Handle2294981 Occurrence Handle1:STN:280:DyaK3c7gsFGksA%3D%3D Occurrence Handle10.1016/0006-3223(90)90648-L
L Björk LJ Cornfield DL Nelson SE Hillver NE Anden T Lewander U Hacksell (1991) ArticleTitlePharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects J Pharmacol Exp Ther 258 58–65 Occurrence Handle1830099
L Björk A Fredriksson U Hacksell T Lewander (1992) ArticleTitleEffects of (R)-8-OH-DPAT and the enantiomers of UH-301 on motor activities in the rat: antagonism of (R)-8-OH-DPAT-induced effects Eur Neuropsychopharmacol 2 141–147 Occurrence Handle1385999 Occurrence Handle10.1016/0924-977X(92)90024-3
NM de Bruin BA Ellenbroek EL van Luijtelaar AR Cools KE Stevens (2001) ArticleTitleHippocampal and cortical sensory gating in rats: effects of quinpirole microinjections in nucleus accumbens core and shell Neuroscience 105 169–180 Occurrence Handle11483310 Occurrence Handle1:CAS:528:DC%2BD3MXlsFymtLc%3D Occurrence Handle10.1016/S0306-4522(01)00183-X
V Bubenikova M Votava J Horacek T Palenicek C Dockery (2005) ArticleTitleThe effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating Pharmacol Biochem Behav 80 591–596 Occurrence Handle15820528 Occurrence Handle1:CAS:528:DC%2BD2MXivFKmtrY%3D Occurrence Handle10.1016/j.pbb.2005.01.012
PW Burnet SL Eastwood PJ Harrison (1997) ArticleTitle[3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia Neurochem Int 30 565–574 Occurrence Handle9152998 Occurrence Handle1:CAS:528:DyaK2sXjtFensL8%3D Occurrence Handle10.1016/S0197-0186(96)00124-6
PW Burnet SL Eastwood PJ Harrison (1996) ArticleTitle5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia Neuropsychopharmacol 15 442–455 Occurrence Handle1:STN:280:ByiD2s7hvFY%3D Occurrence Handle10.1016/S0893-133X(96)00053-X
GF Busatto RW Kerwin (1997) ArticleTitlePerspectives on the role of serotonergic mechanisms in the pharmacology of schizophrenia J Psychopharmacol 11 3–12 Occurrence Handle9097883 Occurrence Handle1:CAS:528:DyaK2sXmtlCitrg%3D
LJ Cornfield G Lambert LE Arvidsson C Mellin J Vallgarda U Hacksell DL Nelson (1991) ArticleTitleIntrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase Mol Pharmacol 39 780–787 Occurrence Handle1828859 Occurrence Handle1:CAS:528:DyaK3MXkvVGmur0%3D
NA Darmani SL Reeves (1996) ArticleTitleThe mechanism by which the selective 5-HT1A receptor antagonist S-(−)-UH-301 produces head-twitches in mice Pharmacol Biochem Behav 55 1–10 Occurrence Handle8870031 Occurrence Handle1:CAS:528:DyaK28XltlyltL8%3D Occurrence Handle10.1016/0091-3057(96)00072-X
A Dirks T Pattij JA Bouwknecht TT Westphal TH Hijzen L Groenink J van der Gugten RS Oosting R Hen MA Geyer B Olivier (2001) ArticleTitle5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response Behav Brain Res 118 169–178 Occurrence Handle11164514 Occurrence Handle1:CAS:528:DC%2BD3MXnsVCguw%3D%3D Occurrence Handle10.1016/S0166-4328(00)00326-0
SC Dulawa MA Geyer (2000) ArticleTitleEffects of strain and serotonergic agents on prepulse inhibition and habituation in mice Neuropharmacology 39 2170–2179 Occurrence Handle10963760 Occurrence Handle1:CAS:528:DC%2BD3cXlvFSru74%3D Occurrence Handle10.1016/S0028-3908(00)00030-7
SC Dulawa R Hen K Scearce-Levie MA Geyer (1997) ArticleTitleSerotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout mice Psychopharmacology 132 125–134 Occurrence Handle9266609 Occurrence Handle1:CAS:528:DyaK2sXlt1Wntb4%3D Occurrence Handle10.1007/s002130050328
M Farid ZA Martinez MA Geyer NR Swerdlow (2000) ArticleTitleRegulation of sensorimotor gating of the startle reflex by serotonin 2A receptors. Ontogeny and strain differences Neuropsychopharmacology 23 623–632 Occurrence Handle11063918 Occurrence Handle1:CAS:528:DC%2BD3cXosFWltrw%3D Occurrence Handle10.1016/S0893-133X(00)00163-9
R Freedman LE Adler P Bickford W Byerley H Coon CM Cullum JM Griffith JG Harris S Leonard C Miller (1994) ArticleTitleSchizophrenia and nicotinic receptors Harv Rev Psychiatry 2 179–192 Occurrence Handle9384901 Occurrence Handle1:STN:280:DyaK1c%2Fjs1yhtg%3D%3D
R Freedman LE Adler GA Gerhardt M Waldo N Baker GM Rose C Drebing H Nagamoto P Bickford-Wimer R Franks (1987) ArticleTitleNeurobiological studies of sensory gating in schizophrenia Schizophrenia Bull 13 669–678 Occurrence Handle1:STN:280:DyaL1c7ksFGmsQ%3D%3D
R Freedman LE Adler MC Waldo E Pachtman RD Franks (1983) ArticleTitleNeurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients Biol Psychiatry 18 537–551 Occurrence Handle6134559 Occurrence Handle1:STN:280:DyaL3s3jtFKhtg%3D%3D
MA Geyer (1996) ArticleTitleSerotonergic functions in arousal and motor activity Behav Brain Res 73 31–35 Occurrence Handle8788473 Occurrence Handle1:STN:280:BymA1c%2Fks1Q%3D Occurrence Handle10.1016/0166-4328(96)00065-4
MA Geyer K Krebs-Thomson DL Braff NR Swerdlow (2001) ArticleTitlePharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review Psychopharmacology 156 117–154 Occurrence Handle11549216 Occurrence Handle1:CAS:528:DC%2BD3MXmtlCqtLY%3D Occurrence Handle10.1007/s002130100811
A Gogos M van den Buuse (2003) ArticleTitleCastration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats Behav Neurosci 117 1407–1415 Occurrence Handle14674858 Occurrence Handle1:CAS:528:DC%2BD2cXkslKitQ%3D%3D Occurrence Handle10.1037/0735-7044.117.6.1407
L Groenink J Van der Gugten J Mos RA Maes B Olivier (1995) ArticleTitleThe corticosterone-enhancing effects of the 5-HT1A receptor antagonist, (S)-UH-301, are not mediated by the 5-HT1A receptor Eur J Pharmacol 272 177–183 Occurrence Handle7713161 Occurrence Handle1:CAS:528:DyaK2MXjt1Snu7o%3D Occurrence Handle10.1016/0014-2999(94)00645-N
EV Gurevich JN Joyce (1997) ArticleTitleAlterations in the cortical serotonergic system in schizophrenia: a postmortem study Biol Psychiatry 42 529–545 Occurrence Handle9376449 Occurrence Handle1:STN:280:DyaK1c%2FitV2ruw%3D%3D Occurrence Handle10.1016/S0006-3223(97)00321-1
K Hashimoto M Iyo R Freedman KE Stevens (2005) ArticleTitleTropisetron improves deficient inhibitory auditory processing in DBA/2 mice: Role of α7 nicotinic acetylcholine receptors Psychopharmacology 183 13–19 Occurrence Handle16136299 Occurrence Handle1:CAS:528:DC%2BD2MXhtFemurrJ Occurrence Handle10.1007/s00213-005-0142-0
T Hashimoto N Kitamura Y Kajimoto Y Shirai O Shirakawa T Mita N Nishino C Tanaka (1993) ArticleTitleDifferential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia Psychopharmacology 112 IssueIDSuppl 35–39 Occurrence Handle10.1007/BF02245005
KM Hershman R Freedman PC Bickford (1995) ArticleTitleGABAB antagonists diminish the inhibitory gating of auditory response in the rat hippocampus Neurosci Lett 190 133–136 Occurrence Handle7644122 Occurrence Handle1:CAS:528:DyaK2MXls12nsr4%3D Occurrence Handle10.1016/0304-3940(95)11523-Y
SE Hillver L Bjork YL Li B Svensson S Ross NE Anden U Hacksell (1990) ArticleTitle(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist J Med Chem 33 1541–1544 Occurrence Handle2140413 Occurrence Handle1:CAS:528:DyaK3cXitlCqsb0%3D Occurrence Handle10.1021/jm00168a002
J Ichikawa T Kuroki MT Kitchen HY Meltzer (1995) ArticleTitleR(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens Eur J Pharmacol 287 179–184 Occurrence Handle8749033 Occurrence Handle1:CAS:528:DyaK2MXpslKisrs%3D Occurrence Handle10.1016/0014-2999(95)00624-9
RG Johnson KE Stevens GM Rose (1998) ArticleTitle5-Hydroxytryptamine2 receptors modulate auditory filtering in the rat J Pharmacol Exp Ther 285 643–650 Occurrence Handle9580608 Occurrence Handle1:CAS:528:DyaK1cXjtF2gu78%3D
K Koike K Hashimoto N Taka E Shimizu N Komatsu H Watanabe M Nakazato N Okamura KE Stevens R Freedman M Iyo (2005) ArticleTitleTropisetron improves deficits of auditory sensory P50 suppression in schizophrenic patients Schizophrenia Res 76 67–72 Occurrence Handle10.1016/j.schres.2004.12.016
R Kuczenski D Segal (1989) ArticleTitleConcomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis J Neurosci 9 2051–2065 Occurrence Handle2566664 Occurrence Handle1:CAS:528:DyaL1MXksFShu7k%3D
T Kuroki J Dai JY Meltzer J Ichikawa (2000) ArticleTitleR(+)-OH-DPAT, a selective 5-HT1A receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex Brain Res 872 204–207 Occurrence Handle10924694 Occurrence Handle1:CAS:528:DC%2BD3cXltlektLo%3D Occurrence Handle10.1016/S0006-8993(00)02437-9
V Luntz-Leybman PC Bickford R Freedman (1992) ArticleTitleCholinergic gating of response to auditory stimuli in rat hippocampus Brain Res 587 130–136 Occurrence Handle1525643 Occurrence Handle1:CAS:528:DyaK38Xls1Cmtrk%3D Occurrence Handle10.1016/0006-8993(92)91437-J
HY Meltzer (1999) ArticleTitleThe role of serotonin in antipsychotic drug action Neuropsychopharmacology 21 IssueIDSuppl 106–115
MJ Millan (2000) ArticleTitleImproving the treatment of schizophrenia: focus on serotonin (5-HT) 1A receptors J Pharmacol Exp Ther 295 853–861 Occurrence Handle11082417 Occurrence Handle1:CAS:528:DC%2BD3cXosVKju7o%3D
CL Miller R Freedman (1993) ArticleTitleMedial septal neuron activity in relation to an auditory sensory gating paradigm Neuroscience 55 373–380 Occurrence Handle7690909 Occurrence Handle1:STN:280:ByyA1M%2FntlE%3D Occurrence Handle10.1016/0306-4522(93)90506-B
JL Moreau G Griebel F Jenck JR Martin U Widmer WE Haefely (1993) ArticleTitleBehavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys Brain Res Bull 29 901–904 Occurrence Handle10.1016/0361-9230(92)90163-R
GG Nomikos L Arborelius BB Hook U Hacksell TH Svensson (1996) ArticleTitleThe 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum J Neural Transm 103 541–554 Occurrence Handle8811500 Occurrence Handle1:CAS:528:DyaK28XltVahsLc%3D Occurrence Handle10.1007/BF01273152
HC O’Neill K Rieger WR Kem KE Stevens (2003) ArticleTitleDMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats Psychopharmacology 169 332–339 Occurrence Handle12759805 Occurrence Handle1:CAS:528:DC%2BD3sXnvVCgtrw%3D Occurrence Handle10.1007/s00213-003-1482-2
GC Rigdon JK Weatherspoon (1992) ArticleTitle5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex J Pharmacol Exp Ther 263 486–493 Occurrence Handle1432685 Occurrence Handle1:CAS:528:DyaK3sXlt1amsA%3D%3D
JK Simosky KE Stevens WR Kem R Freedman (2001) ArticleTitleIntragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice Biol Psychiatry 50 493–500 Occurrence Handle11600102 Occurrence Handle1:CAS:528:DC%2BD3MXntlOqsL8%3D Occurrence Handle10.1016/S0006-3223(01)01093-9
TA Sipes MA Geyer (1994) ArticleTitleMultiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats Neuropharmacology 33 441–448 Occurrence Handle7984282 Occurrence Handle1:CAS:528:DyaK2cXjtFKms7Y%3D Occurrence Handle10.1016/0028-3908(94)90074-4
TA Sipes MA Geyer (1995) ArticleTitle8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action Psychopharmacology 117 41–48 Occurrence Handle7724701 Occurrence Handle1:CAS:528:DyaK2MXkslSis74%3D Occurrence Handle10.1007/BF02245096
TE Sipes MA Geyer (1997) ArticleTitleDOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum Brain Res 761 97–104 Occurrence Handle9247071 Occurrence Handle1:CAS:528:DyaK2sXjslKmtr4%3D Occurrence Handle10.1016/S0006-8993(97)00316-8
CF Smith S Cutts (1990) ArticleTitleDopamine agonist activity of 8-OH-DPAT Int Pharmacodyn Ther 306 106–113 Occurrence Handle1:CAS:528:DyaK3MXnsFSrsg%3D%3D
JS Sprouse LS Reynolds JP Braselton H Rollema SH Zorn (1999) ArticleTitleComparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation Neuropsychopharmacology 21 622–631 Occurrence Handle10516958 Occurrence Handle1:CAS:528:DyaK1MXmsFaitrY%3D Occurrence Handle10.1016/S0893-133X(99)00057-3
KE Stevens LL Fuller GM Rose (1991) ArticleTitleDopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating potentials Brain Res 555 91–98 Occurrence Handle1681997 Occurrence Handle1:CAS:528:DyaK3MXlsFKgtbo%3D Occurrence Handle10.1016/0006-8993(91)90864-R
KE Stevens J Meltzer GM Rose (1993) ArticleTitleDisruption of sensory gating by the α2 selective noradrenergic antagonist yohimbine Biol Psychiatry 33 130–132 Occurrence Handle8439602 Occurrence Handle1:CAS:528:DyaK3sXisVyhsLw%3D Occurrence Handle10.1016/0006-3223(93)90313-3
KE Stevens WR Kem VM Mahnir R Freedman (1998) ArticleTitleSelective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice Psychopharmacology 136 320–327 Occurrence Handle9600576 Occurrence Handle1:CAS:528:DyaK1cXivFKktro%3D Occurrence Handle10.1007/s002130050573
KE Stevens R Freedman AC Collins M Hall S Leonard MJ Marks GM Rose (1996a) ArticleTitleGenetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains Neuropsychopharmacology 15 152–162 Occurrence Handle1:CAS:528:DyaK28XltValsb0%3D Occurrence Handle10.1016/0893-133X(95)00178-G
KE Stevens J Luthman E Lindqvist RG Johnson GM Rose (1996b) ArticleTitleEffects of neonatal dopamine depletion on sensory inhibition in the rat Pharmacol Biochem Behav 53 817–823 Occurrence Handle1:CAS:528:DyaK28XhvFersL8%3D Occurrence Handle10.1016/0091-3057(95)02083-7
T Sumiyoshi CA Stockmeier JC Overholser GE Dilley HY Meltzer (1996) ArticleTitleSerotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia Brain Res 708 209–214 Occurrence Handle8720882 Occurrence Handle1:CAS:528:DyaK28Xht1Wls7w%3D Occurrence Handle10.1016/0006-8993(95)01361-X
T Sumiyoshi M Matsui I Yamashita S Nohara M Kurachi T Uehara S Sumiyoshi C Sumiyoshi HY Meltzer (2001) ArticleTitleThe effect of tandospirone, a serotonin(1A) agonist, on memory function in schizophrenia Biol Psychiatry 49 861–868 Occurrence Handle11343682 Occurrence Handle1:CAS:528:DC%2BD3MXjtlegsLs%3D Occurrence Handle10.1016/S0006-3223(00)01025-8
NR Swerdlow MA Geyer JM Shoemaker GA Light DL Braff KE Stevens R Sharp M Breier A Neary PP Auerbach (2006) ArticleTitleConvergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats Neuropsychopharmacology 31 506–515 Occurrence Handle16123772 Occurrence Handle1:CAS:528:DC%2BD28XhsVKqtbo%3D Occurrence Handle10.1038/sj.npp.1300841
NR Swerdlow RS Mansbach MA Geyer L Pulvirenti GF Koob DL Braff (1990) ArticleTitleAmphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine Psychopharmacology 100 413–4166 Occurrence Handle2315438 Occurrence Handle1:CAS:528:DyaK3cXhtlans7w%3D Occurrence Handle10.1007/BF02244616
G Tanda E Carboni GR Frau G DiChiara (1994) ArticleTitleIncrease of extracellular dopamine in the prefrontal cortex: a train of drugs with antidepressant potential? Psychopharmacology 115 285–288 Occurrence Handle7862908 Occurrence Handle1:CAS:528:DyaK2cXksleks7c%3D Occurrence Handle10.1007/BF02244785
J Tauscher S Kapur NP Verhoeff DF Hussey ZJ Daskalakis S Tauscher-Wisniewski AA Wilson S Houle S Kasper RB Zipursky (2002) ArticleTitleBrain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635 Arch Gen Psychiatry 59 514–520 Occurrence Handle12044193 Occurrence Handle1:CAS:528:DC%2BD38XltFSjsrs%3D Occurrence Handle10.1001/archpsyc.59.6.514
GB Varty VP Bakshi MA Geyer (1999) ArticleTitleM100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats Neuropsychopharmacology 20 311–321 Occurrence Handle10088132 Occurrence Handle1:CAS:528:DyaK1MXitVSntbo%3D Occurrence Handle10.1016/S0893-133X(98)00072-4
ML Wadenberg (1996) ArticleTitleSerotonergic mechanisms in neuroleptic-induced catalepsy in the rat Neurosci Biobehav Rev 20 325–339 Occurrence Handle8811720 Occurrence Handle1:CAS:528:DyaK28XkvV2ht70%3D Occurrence Handle10.1016/0149-7634(95)00057-7
ML Wadenberg V Hillegaart (1995) ArticleTitleStimulation of median, but not dorsal, raphe 5-HT1A autoreceptors by the local application of 8-OH-DPAT reverses raclopride-induced catalepsy in the rat Neuropharmacology 34 495–499 Occurrence Handle7566483 Occurrence Handle1:CAS:528:DyaK2MXmsF2iuro%3D Occurrence Handle10.1016/0028-3908(95)00013-V
ML Wadenberg L Cortizo S Ahlenius (1994) ArticleTitleEvidence for specific interactions between 5-HT1A and dopamine D2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat Pharmacol Biochem Behav 47 509–513 Occurrence Handle8208768 Occurrence Handle1:CAS:528:DyaK2cXhvVers78%3D Occurrence Handle10.1016/0091-3057(94)90152-X
MC Waldo R Freedman (1986) ArticleTitleGating of auditory evoked responses in normal college students Psychiatry Res 19 233–239 Occurrence Handle3797550 Occurrence Handle1:STN:280:DyaL2s%2Fpt1yisQ%3D%3D Occurrence Handle10.1016/0165-1781(86)90102-2
Author information
Authors and Affiliations
Additional information
Present address: Research Area CNS & Pain Control, AstraZeneca R & D, SE-151 85 Södertälje, Sweden.
Rights and permissions
About this article
Cite this article
Stevens, K., O’Neill, H., Rose, G. et al. The 5-HT1A receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats. Amino Acids 31, 365–375 (2006). https://doi.org/10.1007/s00726-006-0374-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00726-006-0374-2