Summary.
Activated phagocytes generate the potent oxidant hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is known to react with a number of biological targets including proteins, DNA, lipids and cholesterol. Proteins are likely to be major targets for reaction with HOCl within a cell due to their abundance and high reactivity with HOCl. This review summarizes information on the rate of reaction of HOCl with proteins, the nature of the intermediates formed, the mechanisms involved in protein oxidation and the products of these reactions. The predicted targets for reaction with HOCl from kinetic modeling studies and the consequences of HOCl-induced protein oxidation are also discussed.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hawkins, C., Pattison, D. & Davies, M. Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids 25, 259–274 (2003). https://doi.org/10.1007/s00726-003-0016-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00726-003-0016-x