Summary.
Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
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Received July 6, 2001 Accepted August 6, 2001 Published online June 17, 2002
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Baker, D., Shen, H. & Kalivas, P. Cystine/glutamate exchange serves as the source for extracellular glutamate: Modifications by repeated cocaine administration. Amino Acids 23, 161–162 (2002). https://doi.org/10.1007/s00726-001-0122-6
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DOI: https://doi.org/10.1007/s00726-001-0122-6