Summary.
Three-component Mannich-type reaction of cyclohexanone, aromatic aldehydes, and aromatic amines was catalyzed by a basic functionalized ionic liquid, 1-butyl-3-methylimidazolium hydroxide ([bmim][OH]), at room temperature to give various β-amino carbonyl compounds in high yields. The ionic liquid, which is environmentally friendly, can be recycled at least 5 times without significant loss of activity.
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Gong, K., Fang, D., Wang, HL. et al. Basic Functionalized Ionic Liquid Catalyzed One-pot Mannich-type Reaction: Three Component Synthesis of β-Amino Carbonyl Compounds. Monatsh. Chem. 138, 1195–1198 (2007). https://doi.org/10.1007/s00706-007-0767-2
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DOI: https://doi.org/10.1007/s00706-007-0767-2