Summary.
The environment-friendly one-pot three-component condensation reactions of 4-hydroxycoumarin or 4-hydroxy-6-methylpyrone, p-substituted benzaldehyde, and alkyl or aryl isocyanides to afford furocoumarines or furopyranones in water in good yields after about one hour at 75°C are reported.
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Shaabani, A., Teimouri, M. & Bijanzadeh, H. One-pot Three-component Condensation Reactions in Water. An Efficient and Improved Procedure for the Synthesis of Furan Annulated Heterocycles. Monatshefte für Chemie 135, 589–593 (2004). https://doi.org/10.1007/s00706-003-0126-x
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DOI: https://doi.org/10.1007/s00706-003-0126-x