Summary.
Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks. We investigated PrP gene polymorphisms in scrapie-affected and clinically healthy Sarda breed sheep from a flock exposed to the aforementioned vaccine, and in affected Sarda sheep from unexposed flocks. All affected animals were (Gln/Gln)171 homozygous. Moreover, we observed no variation for Ala136 and a new polymorphism (Lys to Asn) at codon 176. Our findings confirm the correlation between scrapie and (Gln/Gln)171 in breeds with no variation for Ala136.
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Accepted June 18, 2001 Recevied March 19, 2001
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Vaccari, G., Petraroli, R., Agrimi, U. et al. PrP genotype in Sarda breed sheep and its relevance to scrapie. Arch. Virol. 146, 2029–2037 (2001). https://doi.org/10.1007/s007050170050
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DOI: https://doi.org/10.1007/s007050170050