Summary.
In addition to Aβ plaques and neurofibrillary tangles, Alzheimer’s disease (AD) is characterized by increased brain levels of APP C-terminal fragments. In the present investigation, the cholinergic innervation in forebrain regions of transgenic mice (Tg13592) expressing the human βAPP C99 fragment was compared to that of non-transgenic controls by measuring the activity of the non-specific catabolic enzyme, acetylcholinesterase (AChE). The AchE activity of Tg13592 mice was altered in several regions implicated in the functional loop of regulation between septum and hippocampus, vulnerable in Alzheimer pathology and critically involved in cognitive functions. In particular, AChE activity was upregulated in three basal forebrain regions containing cholinergic cell bodies, prelimbic cortex, anterior subiculum, and paraventricular thalamus, but downregulated in lateral septum and reticular thalamus. The increased activity in medial septum and anterior subiculum was linearly correlated with poor performances in a spatial learning task, possibly due to cell stress mechanisms. Because of some similarities in terms of neurochemistry and behavior, this mouse model may be of use for studying prodromal AD.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
J Apelt A Kumar R Schliebs (2002) ArticleTitleImpairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human β-amyloid precursor protein Brain Res 953 17–30 Occurrence Handle12384234 Occurrence Handle1:CAS:528:DC%2BD38XnvVOlurw%3D Occurrence Handle10.1016/S0006-8993(02)03262-6
JR Atack EK Perry JR Bonham RH Perry BE Tomlinson G Blessed A Fairbairn (1983) ArticleTitleMolecular forms of acetylcholinestrase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form Neurosci Lett 40 199–204 Occurrence Handle6633975 Occurrence Handle1:CAS:528:DyaL3sXlsleqsbY%3D Occurrence Handle10.1016/0304-3940(83)90302-6
M Bartolini C Bertucci V Cavrini V Andrisano (2003) ArticleTitleβ-amyloid aggregation induced by human acetylcholinesterase: inhibition studies Biochem Pharmacol 65 407–416 Occurrence Handle12527333 Occurrence Handle1:CAS:528:DC%2BD3sXivVKitA%3D%3D Occurrence Handle10.1016/S0006-2952(02)01514-9
DS Baskin JL Browning FJ Pirozzolo S Korporaal JA Baskin SH Appel (1999) ArticleTitleBrain choline acetyltransferase and mental function in Alzheimer disease Arch Neurol 56 1121–1123 Occurrence Handle10488813 Occurrence Handle1:STN:280:DyaK1Mvhs12itA%3D%3D Occurrence Handle10.1001/archneur.56.9.1121
R Beeri C Andres E Lev-Lehman R Timberg T Huberman M Shani H Soreq (1995) ArticleTitleTransgenic overexpression of human acetylcholinesterase induces progressive cognitive deterioration in mice Curr Biol 5 1063–1071 Occurrence Handle8542283 Occurrence Handle1:CAS:528:DyaK2MXotVSgtLc%3D Occurrence Handle10.1016/S0960-9822(95)00211-9
G Bissette FJ Seidler CB Nemeroff TA Slotkin (1996) ArticleTitleHigh affinity choline transporter status in Alzheimer’s disease tissue from rapid autopsy Ann NY Acad Sci 777 197–204 Occurrence Handle8624084 Occurrence Handle1:STN:280:BymC1cjgtFw%3D
JK Blusztajn B Berse (2000) ArticleTitleThe cholinergic neuronal phenotype in Alzheimer’s disease Met Brain Dis 15 45–64 Occurrence Handle1:CAS:528:DC%2BD3cXltFOnsr0%3D Occurrence Handle10.1023/A:1011161718572
S Boncristiano ME Calhoun PH Kelly M Pfeifer L Bondolfi M Stalder AL Phinney D Abramoski C Sturchler-Pierrat A Enz B Sommer M Staufenbiel M Jucker (2002) ArticleTitleCholinergic hypothesis in the APP23 transgenic mouse model of cerebral amyloidosis J Neurosci 22 3234–3243 Occurrence Handle11943824 Occurrence Handle1:CAS:528:DC%2BD38XjtF2gt7c%3D
DM Bowen JS Benton JA Spillane CCT Smith SJ Allen (1982) ArticleTitleCholine acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients J Neurol Sci 57 191–202 Occurrence Handle7161618 Occurrence Handle1:STN:280:BiyC3sjnvVw%3D Occurrence Handle10.1016/0022-510X(82)90026-0
DM Bowen CB Smith P White AN Davison (1976) ArticleTitleNeurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies Brain 99 459–496 Occurrence Handle11871 Occurrence Handle1:STN:280:CSiD28njsVw%3D
FC Bronfman D Moechars FW Van Leuven (2000) ArticleTitleAcetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein London mutant transgenic mice Neurobiol Dis 7 152–168 Occurrence Handle10860782 Occurrence Handle1:CAS:528:DC%2BD3cXktVKlu7c%3D Occurrence Handle10.1006/nbdi.2000.0283
LL Butcher (1995) Cholinergic neurons and networks G Paxinos (Eds) The rat nervous system Academic Press New York 1003–1015
MA Chacon AE Reyes NC Inestrosa (2003) ArticleTitleAcetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus J Neurochem 87 195–204 Occurrence Handle12969266 Occurrence Handle1:CAS:528:DC%2BD3sXotFSktr0%3D Occurrence Handle10.1046/j.1471-4159.2003.01985.x
Choi SH, Park CH, Koo JW, Seo J-H, Kim H-S, Jeong S-J, Lee J-H, Kim SS, Suh Y-H (2001) Memory impairment and cholinergic dysfunction by centrally administered Aβ and carboxy-terminal fragment of Alzheimer’s APP in mice. FASEB J (June 18) 10.1096/fj00-0859fje
JT Coyle DL Price MR DeLong (1983) ArticleTitleAlzheimer’s disease: a disorder of cortical cholinergic innervation Science 219 1184–1190 Occurrence Handle6338589 Occurrence Handle1:STN:280:BiyC2cnjtlQ%3D
Davies P, Maloney AJF (1976) Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet ii: 1943
ST DeKosky RE Harbaugh FA Schmitt RAE Bakay HC Chui DS Knopman TM Reeder AG Shetter HJ Senter WR Markesbery (1992) ArticleTitleCortical biopsy in Alzheimer’s disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations Ann Neurol 32 625–632 Occurrence Handle1360195 Occurrence Handle1:STN:280:ByyD1c%2FivFY%3D Occurrence Handle10.1002/ana.410320505
ST DeKosky MD Ikonomovic SD Styren L Beckett S Wisniewski DA Bennett EJ Cochran JH Kordower EJ Mufson (2002) ArticleTitleUpregulation of cholinetransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment Ann Neurol 51 145–155 Occurrence Handle11835370 Occurrence Handle1:CAS:528:DC%2BD38XhvFGit7Y%3D Occurrence Handle10.1002/ana.10069
DA Drachman J Leavitt (1974) ArticleTitleHuman memory and the cholinergic system – a relationship to aging? Arch Neurol 30 113–121 Occurrence Handle4359364 Occurrence Handle1:CAS:528:DyaE2cXhsVWhs7o%3D
B Dubois ML Albert (2004) ArticleTitleAmnestic MCI or prodromal Alzheimer’s disease? Lancet Neurol 3 246–248 Occurrence Handle15039037 Occurrence Handle10.1016/S1474-4422(04)00710-0
GL Ellman KD Courtney VJ Andres RM Featherstone (1961) ArticleTitleA new and rapid colorimetric determination of acetylcholinesterase activity Biochem Pharmacol 7 88–95 Occurrence Handle13726518 Occurrence Handle1:CAS:528:DyaF3MXht1Gns7o%3D Occurrence Handle10.1016/0006-2952(61)90145-9
LR Fodero SS Mok D Losic LL Martin MI Aguilar CJ Barrow BG Livett DH Small (2004) ArticleTitleα7- Nicotinic acetylcholine receptors mediate an Aβ1–42-induced increase in the level of acetylcholinesterase in primary cortical neurones J Neurochem 88 1186–1193 Occurrence Handle15009674 Occurrence Handle1:CAS:528:DC%2BD2cXhvFOru78%3D Occurrence Handle10.1046/j.1471-4159.2003.02296.x
LR Fodero J Saez-Valero CA McLean RN Martins K Beyreuther CL Masters TA Robertson DH Small (2002) ArticleTitleAltered glycosylation of acetylcholinesterase in APP(sw) Tg2576 transgenic mice occurs prior to amyloid plaque deposition J Neurochem 81 441–448 Occurrence Handle12065653 Occurrence Handle1:CAS:528:DC%2BD38XjsFGktrs%3D Occurrence Handle10.1046/j.1471-4159.2002.00902.x
KBJ Franklin G Paxinos (1997) The mouse brain in stereotaxic coordinates Academic Press New York
L Frölich (2002) ArticleTitleThe cholinergic pathology in Alzheimer’s disease: discrepancies between clinical experience and pathophysiological findings J Neural Transm 109 1003–1014 Occurrence Handle12111437 Occurrence Handle10.1007/s007020200083
K Fukuchi D Pham M Hart L Li JR Lindsey (1998) ArticleTitleAmyloid-β deposition in skeletal muscle of transgenic mice: possible model of inclusion body myopathy Am J Pathol 153 1687–1693 Occurrence Handle9846958 Occurrence Handle1:CAS:528:DyaK1cXotV2kuro%3D
K Fukuchi B Sopher CE Furlong AC Smith N Dang GM Martin (1993) ArticleTitleSelective neurotoxicity of COOH-terminal fragments of the β-amyloid-precursor protein Neurosci Lett 154 145–148 Occurrence Handle8361630 Occurrence Handle1:CAS:528:DyaK3sXlsFOnu7s%3D Occurrence Handle10.1016/0304-3940(93)90192-N
K Fukuchi L Ho SG Younkin DD Kunkel CE Ogburn RC LeBoeuf CE Furlong SS Deeb D Nochlin J Wegiel MH Wisniewski GM Martin (1996) ArticleTitleHigh levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice Am J Pathol 149 219–227 Occurrence Handle8686746 Occurrence Handle1:CAS:528:DyaK28XkslKhsbs%3D
P Gomez-Ramos EJ Mufson MA Moran (1992) ArticleTitleUltrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer’s brain Brain Res 569 229–237 Occurrence Handle1540829 Occurrence Handle1:CAS:528:DyaK38XhtVektr4%3D Occurrence Handle10.1016/0006-8993(92)90634-L
A Gonzalo-Ruiz JM Sanz (2002) ArticleTitleAlteration of cholinergic, excitatory amino acid and neuropeptide markers in the septum-diagonal band complex following injections of fibrillar β-amyloid protein into the retrosplenial granular cortex of the rat Eur J Anat 6 95–107
MN Gordon CE Finch (1984) ArticleTitleTopochemical localization of choline acetyltransferase and acetylcholinesterase in mouse brain Brain Res 308 364–368 Occurrence Handle6478212 Occurrence Handle1:CAS:528:DyaL2cXlsVCktLs%3D Occurrence Handle10.1016/0006-8993(84)91079-5
JJ Hagan JD Salamone J Simpson SD Iversen RGM Morris (1988) ArticleTitlePlace navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis Behav Brain Res 27 9–20 Occurrence Handle3342117 Occurrence Handle1:STN:280:BieC3svlsFE%3D Occurrence Handle10.1016/0166-4328(88)90105-2
J Hardy R Adolfsson I Alafuzoff G Bucht J Marcusson P Nyberg E Perdahl P Wester B Winblad (1985) ArticleTitleTransmitter deficits in Alzheimer’s disease Neurochem Int 7 545–563 Occurrence Handle10.1016/0197-0186(85)90050-6
R Hellweg C Humpel A Lowe H Hortnagl (1997) ArticleTitleModerate lesion of the rat cholinergic septohippocampal pathway increases hippocampal nerve growth factor synthesis: evidence for long-term compensatory changes? Mol Brain Res 45 177–181 Occurrence Handle9105689 Occurrence Handle1:CAS:528:DyaK2sXhtlygurk%3D Occurrence Handle10.1016/S0169-328X(96)00310-5
K Herholtz S Weisenbach G Zündorf O Lenz H Schröder B Bauer E Kalbe W-D Heiss (2004) ArticleTitleIn vivo study of acetylcholinesterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease NeuroImage 21 136–143 Occurrence Handle10.1016/j.neuroimage.2003.09.042
NC Inestrosa A Alvarez CA Perez RD Moreno M Vicente C Linker OI Casanueva C Soto J Garrido (1996) ArticleTitleAcetylcholinesterase accelerates assembly of amyloid β-peptides into Alzheimer’s fibrils: possible role of the peripheral site of the enzyme Neuron 16 881–891 Occurrence Handle8608006 Occurrence Handle1:CAS:528:DyaK28XislCmsLk%3D Occurrence Handle10.1016/S0896-6273(00)80108-7
S Jaffar SE Counts SY Ma E Dadko MN Gordon D Morgan EJ Mufson (2001) ArticleTitleNeuropathology of mice carrying APPSWE and/or PS1M146L transgenes: alterations in the p75NTR cholinergic basal forebrain septohippocampal pathway Exp Neurol 170 227–243 Occurrence Handle11476589 Occurrence Handle1:CAS:528:DC%2BD3MXlsVWgtLk%3D Occurrence Handle10.1006/exnr.2001.7710
K Jellinger (1988) ArticleTitleThe pedunculopontine nucleus in Parkinson’s disease, progressive supranuclear palsy and Alzheimer’s disease J Neurol Neurosurg Psychiatry 51 540–543 Occurrence Handle3379428 Occurrence Handle1:STN:280:BieB2cvntlc%3D Occurrence Handle10.1136/jnnp.51.4.540
RN Kalaria SN Kroon I Grahovac G Perry (1992) ArticleTitleAcetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer’s disease Neuroscience 51 177–184 Occurrence Handle1465181 Occurrence Handle1:CAS:528:DyaK3sXnvVGgtQ%3D%3D Occurrence Handle10.1016/0306-4522(92)90482-H
JF Kelly K Furukawa SW Barger MR Rengen RJ Mark EM Blanc GS Roth MP Mattson (1996) ArticleTitleAmyloid β-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons Proc Natl Acad Sci USA 93 6753–6758 Occurrence Handle8692890 Occurrence Handle1:CAS:528:DyaK28XjvFeitr4%3D Occurrence Handle10.1073/pnas.93.13.6753
GB Koelle JS Friendenwald (1949) ArticleTitleA histochemical method for localizing cholinesterase activity Proc Soc Exp Biol Med 70 617–622 Occurrence Handle1:CAS:528:DyaH1MXivFKmtQ%3D%3D Occurrence Handle18149447
C Köhler B Srebro (1980) ArticleTitleEffects of lateral and medial septal lesions on exploratory behavior in the albino rat Brain Res 182 423–440 Occurrence Handle7357393 Occurrence Handle10.1016/0006-8993(80)91199-3
P Kugler A Schleicher K Zilles E Horvath (1993) ArticleTitleAcetylcholinesterase activity and post-lesional plasticity in the hippocampus of young and aged rats Neuroscience 55 91–103 Occurrence Handle8350995 Occurrence Handle1:CAS:528:DyaK3sXlsFalsrY%3D Occurrence Handle10.1016/0306-4522(93)90457-Q
DE Kuhl RA Koeppe S Minoshima SE Snyder EP Ficaro NL Foster KA Frey MR Kilbourn (1999) ArticleTitleIn vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease Neurology 52 691–699 Occurrence Handle10078712 Occurrence Handle1:CAS:528:DyaK1MXhvFGgsLg%3D
R Lalonde M Dumont K Fukuchi C Strazielle (2002) ArticleTitleTransgenic mice expressing the human C99 terminal fragment of βAPP: effects on spatial learning, exploration, anxiety, and motor coordination Exp Gerontol 37 1399–1410 Occurrence Handle10.1016/S0531-5565(02)00123-7
C Leranth M Frotscher (1989) ArticleTitleOrganization of the septal region in the rat brain: cholinergic-GABAergic interconnections and the termination of hippocampo-septal fibers J Comp Neurol 289 304–314 Occurrence Handle2808769 Occurrence Handle1:STN:280:By%2BD3sjntVU%3D Occurrence Handle10.1002/cne.902890210
H-J Lüth J Apelt AO Ihunwo T Arendt R Schliebs (2003) ArticleTitleDegeneration of β-amyloid-associated cholinergic structures in transgenic APPSW mice Brain Res 977 16–22 Occurrence Handle12788508 Occurrence Handle10.1016/S0006-8993(03)02658-1 Occurrence Handle1:CAS:528:DC%2BD3sXkt1egurw%3D
SA Lyness C Zarow HC Chui (2003) ArticleTitleNeuron loss in key cholinergic and aminergic nuclei in Alzheimer’s disease: a meta-analysis Neurobiol Aging 24 1–23 Occurrence Handle12493547 Occurrence Handle1:CAS:528:DC%2BD38XpsFWht7w%3D Occurrence Handle10.1016/S0197-4580(02)00057-X
A Marutle U Warpman N Bogdanovic L Lannfelt A Nordberg (1999) ArticleTitleNeuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor protein 670/671 mutation J Neurochem 72 1161–1169 Occurrence Handle10037489 Occurrence Handle1:CAS:528:DyaK1MXhsFWgsLk%3D Occurrence Handle10.1046/j.1471-4159.2000.0721161.x
RK McNamara RW Skelton (1993) ArticleTitleThe neuropharmacological and neurochemical basis of place learning in the Morris water maze Brain Res Rev 18 33–49 Occurrence Handle8467349 Occurrence Handle1:CAS:528:DyaK3sXksVWjtr0%3D Occurrence Handle10.1016/0165-0173(93)90006-L
DL McPhie RKK Lee CB Eckman DH Olstein ST Durham D Yager SG Younkin RJ Wurtman RL Neve (1997) ArticleTitleNeuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains J Biol Chem 272 24743–24746 Occurrence Handle9312066 Occurrence Handle1:CAS:528:DyaK2sXms1eitLY%3D Occurrence Handle10.1074/jbc.272.40.24743
JB Melo P Agosinho CR Oliveira (2003) ArticleTitleInvolvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by beta-peptide Neurosci Res 45 117–127 Occurrence Handle12507730 Occurrence Handle1:CAS:528:DC%2BD38XpvVaitr4%3D Occurrence Handle10.1016/S0168-0102(02)00201-8
MM Mesulam (2004) ArticleTitleThe cholinergic lesion of Alzheimer’s disease: pivotal factor or side show? Learning and Memory 11 43–49 Occurrence Handle14747516 Occurrence Handle10.1101/lm.69204
MM Mesulam C Geula (1988) ArticleTitleNucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase J Comp Neurol 275 216–240 Occurrence Handle3220975 Occurrence Handle1:STN:280:BiaC38zpsFw%3D Occurrence Handle10.1002/cne.902750205
MM Mesulam EJ Mufson BH Wainer AI Levey (1983) ArticleTitleCentral cholinergic pathways in the rat: an overview based on the alternative nomenclature (Ch1–Ch6) Neuroscience 10 1185–1201 Occurrence Handle6320048 Occurrence Handle1:STN:280:BiuC3MjotFc%3D Occurrence Handle10.1016/0306-4522(83)90108-2
PM Moran LS Higgins B Cordell PC Moser (1995) ArticleTitleAge-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid protein precursor protein Proc Natl Acad Sci USA 92 5341–5345 Occurrence Handle7777509 Occurrence Handle1:CAS:528:DyaK2MXmtFOhurw%3D Occurrence Handle10.1073/pnas.92.12.5341
JC Morris (2002) ArticleTitleChallenging assumptions about Alzheimer’s disease: mild cognitive impairment and the cholinergic hypothesis Ann Neurol 51 143–144 Occurrence Handle11835369 Occurrence Handle10.1002/ana.10135
JC Morris M Storandt JP Miller DW McKeel JL Price EH Rubin L Berg (2001) ArticleTitleMild cognitive impairment represents early-stage Alzheimer’s disease Arch Neurol 58 397–405 Occurrence Handle11255443 Occurrence Handle1:STN:280:DC%2BD3M7pvVCisA%3D%3D Occurrence Handle10.1001/archneur.58.3.397
RGM Morris F Schenk F Tweedie LE Jarrard (1990) ArticleTitleIbotenate lesions of the hippocampus and/or subiculum: dissociating components of allocentric spatial learning Eur J Neurosci 2 1016–1028 Occurrence Handle12106063 Occurrence Handle10.1111/j.1460-9568.1990.tb00014.x
ML Oster-Granite DL McPhie J Greenan RL Neve (1996) ArticleTitleAge-dependent neuronal and synaptic degeneration in mice transgenic for the C-terminus of the amyloid precursor protein J Neurosci 16 6732–6741 Occurrence Handle8824314 Occurrence Handle1:CAS:528:DyaK28Xntlalt7g%3D
G Paxinos C Watson (1986) The rat brain in stereotaxic coordinates Academic Press San Diego
EK Perry PH Gibson G Blessed RH Perry BE Tomlinson (1977) ArticleTitleNeurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue J Neurol Sci 34 247–265 Occurrence Handle144789 Occurrence Handle1:CAS:528:DyaE1cXkvVKmug%3D%3D Occurrence Handle10.1016/0022-510X(77)90073-9
JL Price (1995) Thalamus G Paxinos (Eds) The rat nervous system Academic Press New York 629–645
TA Reader C Strazielle (1999) Quantitative autoradiography of monoamine uptake sites and receptors in rat and mouse brain AA Boulton GB Baker AN Bateson (Eds) Neuromethods, cell neurobiology techniques NumberInSeries33 Humana Press Totowa 1–51 Occurrence Handle10.1385/0-89603-510-7:1
G Sberna J Saez-Valero K Beyreuther CL Masters DH Small (1997) ArticleTitleThe β-amyloid protein of Alzheimer’s disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells J Neurochem 69 1177–1184 Occurrence Handle9282941 Occurrence Handle1:CAS:528:DyaK2sXls1Chtb0%3D
G Sberna J Saez-Valero Q-X Li C Czech K Beyreuther CL Masters CA McLean DH Small (1998) ArticleTitleAcetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the β-amyloid protein precursor of Alzheimer’s disease J Neurochem 71 723–731 Occurrence Handle9681463 Occurrence Handle1:CAS:528:DyaK1cXkslKisLc%3D
LC Schmued KJ Hopkins (2000) ArticleTitleFluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration Brain Res 874 123–130 Occurrence Handle10960596 Occurrence Handle1:CAS:528:DC%2BD3cXlvV2mtb4%3D Occurrence Handle10.1016/S0006-8993(00)02513-0
M Segal V Greenberger M Israeli A Biegon (1988) ArticleTitleA correlation between regional acetylcholinesterase activity in rat brain and performance in a spatial task Behav Brain Res 30 215–219 Occurrence Handle3166718 Occurrence Handle1:CAS:528:DyaL1cXls1Citbw%3D Occurrence Handle10.1016/0166-4328(88)90150-7
H Shinotoh H Namba K Fukushi S Nagatsuka N Tanaka A Aotsuka T Ota S Tanada T Irie (2000) ArticleTitleProgressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer’s disease: a positron emission tomography study Ann Neurol 48 194–200 Occurrence Handle10939570 Occurrence Handle1:CAS:528:DC%2BD3cXlvFKhtb0%3D Occurrence Handle10.1002/1531-8249(200008)48:2<194::AID-ANA9>3.0.CO;2-X
TA Slotkin CB Nemeroff G Bissette FJ Seidler (1994) ArticleTitleOverexpression of the high affinity choline transporter in cortical regions affected by Alzheimer’s disease. Evidence from rapid autopsy studies J Clin Invest 94 696–702 Occurrence Handle8040324 Occurrence Handle1:CAS:528:DyaK2cXltlWmtb4%3D Occurrence Handle10.1172/JCI117387
C Strazielle M Dumont K Fukuchi R Lalonde (2004) ArticleTitleTransgenic mice expressing the human C99 terminal fragment of βAPP: effects on cytochrome oxidase activity in skeletal muscle and brain J Chem Neuroanat 27 237–246 Occurrence Handle15261330 Occurrence Handle1:CAS:528:DC%2BD2cXlsl2ntL0%3D Occurrence Handle10.1016/j.jchemneu.2004.03.009
YH Suh F Checler (2002) ArticleTitleAmyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer’s disease Pharmacol Rev 54 469–525 Occurrence Handle12223532 Occurrence Handle1:CAS:528:DC%2BD38XotVSmsr0%3D Occurrence Handle10.1124/pr.54.3.469
H Tago PL McGeer EG McGeer (1987) ArticleTitleAcetylcholinesterase fibers in the development of senile plaques Brain Res 40 363–369 Occurrence Handle10.1016/0006-8993(87)90808-0
VN Talesa (2001) ArticleTitleAcetylcholinesterase in Alzheimer’s disease Mech Ageing Dev 122 1961–1969 Occurrence Handle11589914 Occurrence Handle1:CAS:528:DC%2BD3MXnt1Sit7Y%3D Occurrence Handle10.1016/S0047-6374(01)00309-8
T Teaktong A Graham J Court R Perry E Jaros M Johnson R Hall E Perry (2003) ArticleTitleAlzheimer’s disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes Glia 41 207–211 Occurrence Handle12509811 Occurrence Handle10.1002/glia.10132
WG Tourtellotte GW Van Hoesen BT Hyman RK Tikoo AR Damasio (1990) ArticleTitleAlz-50 immunoreactivity in the thalamic reticular nucleus in Alzheimer’s disease Brain Res 515 227–234 Occurrence Handle2357561 Occurrence Handle1:STN:280:By%2BB1M7hvFI%3D Occurrence Handle10.1016/0006-8993(90)90600-G
H-Y Wang DHS Lee CB Davis RP Shank (2000) ArticleTitleAmyloid peptide Aβ1–42 binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors J Neurochem 75 1155–1161 Occurrence Handle10936198 Occurrence Handle1:CAS:528:DC%2BD3cXmtFyrs7Y%3D Occurrence Handle10.1046/j.1471-4159.2000.0751155.x
A Wevers L Burghaus N Moser B Witter OK Steinlein U Schütz B Achnitz U Krempel S Nowacki K Pilz J Stoodt J Lindstrom RAI De Vos ENH Jansen Steur H Schröder (2000) ArticleTitleExpression of nicotinic acetylcholine receptors in Alzheimer’s disease: postmortem investigations and experimental approaches Behav Brain Res 113 207–215 Occurrence Handle10942047 Occurrence Handle1:CAS:528:DC%2BD3cXlvFGmtro%3D Occurrence Handle10.1016/S0166-4328(00)00215-1
PJ Whitehouse DL Price RG Struble AW Clark JT Coyle MR Delon (1982) ArticleTitleAlzheimer’s disease and senile dementia: loss of neurons in the basal forebrain Science 215 1237–1239 Occurrence Handle7058341 Occurrence Handle1:STN:280:Bi2C38bhsVM%3D
TP Wong T Debeir K Duff AC Cuello (1999) ArticleTitleReorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes J Neurosci 19 2706–2716 Occurrence Handle10087083 Occurrence Handle1:CAS:528:DyaK1MXitFShtLw%3D
MTT Wong-Riley (1989) ArticleTitleCytochrome oxidase: an endogenous metabolic marker for neuronal activity Trends Neurosci 12 94–101 Occurrence Handle2469224 Occurrence Handle1:CAS:528:DyaL1MXitV2lurc%3D Occurrence Handle10.1016/0166-2236(89)90165-3
CI Wright C Geula M-M Mesulam (1993) ArticleTitleProtease inhibitors and indolamines selectively inhibit cholinesterase in the histopathologic structures of Alzheimer disease Proc Natl Acad Sci USA 90 683–686 Occurrence Handle8421706 Occurrence Handle1:CAS:528:DyaK3sXpsVagtA%3D%3D Occurrence Handle10.1073/pnas.90.2.683
L Yang H-Y He X-J Zhang (2002) ArticleTitleIncreased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells Neurosci Res 42 261–268 Occurrence Handle11985878 Occurrence Handle1:CAS:528:DC%2BD38Xjt1Srt70%3D Occurrence Handle10.1016/S0168-0102(02)00005-6
W-F Yu Z-Z Guan N Bogdanovic A Nordberg (2005) ArticleTitleHigh selective expression of α7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer’s disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques Exp Neurol 192 215–225 Occurrence Handle15698636 Occurrence Handle1:CAS:528:DC%2BD2MXhtVKgs7o%3D Occurrence Handle10.1016/j.expneurol.2004.12.015
P Zatta M Ibn-Lkhayat-Idrissi P Zambenedetti M Kilyen T Kiss (2002) ArticleTitleIn vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase Brain Res Bull 59 41–45 Occurrence Handle12372547 Occurrence Handle1:CAS:528:DC%2BD38Xns1SisLc%3D Occurrence Handle10.1016/S0361-9230(02)00836-5
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dumont, M., Lalonde, R., Ghersi-Egea, JF. et al. Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APP . J Neural Transm 113, 1225–1241 (2006). https://doi.org/10.1007/s00702-005-0373-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00702-005-0373-6