Summary.
To study nicotine’s effects on neurogenesis in the dentate gyrus of the hippocampus, nicotine was injected intraperitoneally into adult rats. After sacrificing, the hippocampal formation was processed for immunohistochemical staining of PSA-NCAM, NeuN and GFAP. Nicotine decreased numbers of PSA-NCAM(+) and NeuN(+) cells dose-dependently.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
VV Kiselyov G Skladchikova AM Hinsby PH Jensen N Kulahin V Soroka N Pedersen V Tsetlin FM Poulsen V Berezin E Bock (2003) ArticleTitleStructural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure (Camb) 11 691–701 Occurrence Handle10.1016/S0969-2126(03)00096-0
JZ Kiss G Rougnon (1997) ArticleTitleCell biology of polysialic acid. Curr Opin Neurobiol 7 640–646 Occurrence Handle10.1016/S0959-4388(97)80083-9 Occurrence Handle9384537
K Kolkova V Novitskaya N Pedersen V Berezin E Bock (2000) ArticleTitleNeural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J Neurosci 20 2238–2246 Occurrence Handle10704499
I Kramer H Hall U Bleistein M Schachner (1997) ArticleTitleDevelopmentally regulated masking of an intracellular epitope of the 180 kDa isoform of the neural cell adhesion molecule NCAM. J Neurosci Res 49 161–175 Occurrence Handle10.1002/(SICI)1097-4547(19970715)49:2<161::AID-JNR5>3.0.CO;2-7 Occurrence Handle9272639
P Niethammer M Delling V Sytnyk A Dityatev K Fukami M Schachner (2002) ArticleTitleCosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol 157 521–532 Occurrence Handle10.1083/jcb.200109059 Occurrence Handle11980923
LC Ronn V Berezin E Bock (2000) ArticleTitleThe neural cell adhesion molecule in synaptic plasticity and ageing. Int J Dev Neurosci 18 193–199 Occurrence Handle10.1016/S0736-5748(99)00088-X Occurrence Handle10715574
U Rutishauser L Landmesser (1996) ArticleTitlePolysialic acid in the vertebrate nervous system: a promoter of plasticity in cell–cell interactions. Trends Neurosci 19 422–427 Occurrence Handle8888519
JL Saffell FS Walsh P Doherty (1994) ArticleTitleExpression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum. J Cell Biol 125 427–436 Occurrence Handle10.1083/jcb.125.2.427 Occurrence Handle8163558
T Seki Y Arai (1993) ArticleTitleDistribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Neurosci Res 17 265–290 Occurrence Handle10.1016/0168-0102(93)90111-3 Occurrence Handle8264989
AS Shingo S Kito (2003) ArticleTitleEstrogen induces insulin-like growth factor-1 mRNA expression in the immortalized hippocampal cell: determination by quantitative real-time polymerase chain reaction. Neurochem Res 28 1379–1383 Occurrence Handle10.1023/A:1024900616704 Occurrence Handle12938861
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shingo, A., Kito, S. Effects of nicotine on neurogenesis and plasticity of hippocampal neurons. J Neural Transm 112, 1475–1478 (2005). https://doi.org/10.1007/s00702-005-0370-2
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00702-005-0370-2