Abstract
A 70-year-old woman diagnosed to have a hepatitis C virus (HCV) infection was referred to our hospital because of a solitary liver tumor. because of a solitary liver tumor. She underwent a partial hepatectomy, and the tumor was histologically diagnosed as a hepatocellular carcinoma (HCC). diagnosed as a hepatocellular carcinoma (HCC). In addition, a focal follicle consisting of atypical lymphoid cells was seen within the HCC. cells was seen within the HCC. Two months later, she was readmitted because of weakness and rapidly developing abdominal fullness. developing abdominal fullness. An abdominal computed tomography scan showed widespread tumors with ascites. with ascites. A cytological examination of the ascites showed large-sized atypical lymphoid cells. showed large-sized atypical lymphoid cells. An immunohistochemical stain confirmed that the atypical lymphoid cells within the HCC were positive for the CD 20 antigen. antigen. Taking these findings into account, the hepatic tumor was determined to be a HCC infiltrated with diffuse large B-cell lymphoma. diffuse large B-cell lymphoma. The coexistence of HCC and non-Hodgkin’s lymphoma (NHL) is extremely rare. and non-Hodgkin’s lymphoma (NHL) is extremely rare. We herein report a case of HCC infiltrated with NHL. We herein report a case of HCC infiltrated with NHL.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Besson C, Canioni D, Lepage E, Pol S, Morel P, Lederlin P, et al. Characteristics and outcome of diffuse large B-cell lymphoma in hepatitis C virus-positive patients in LNH 93 and LNH 98 Groupe d’Etude des Lymphomes de l’Adulte programs. J Clin Oncol 2006;24:953–960.
Schöllkopf C, Smedby KE, Hjalgrim H, Rostgaard K, Panum I, Vinner L, et al. Hepatitis C infection and risk of malignant lymphoma. Int J Cancer 2008;122:1885–1890.
Kondo N, Furuya H, Yamamoto S, Nakano A, Sakashita Y. Diffuse large B-cell lymphoma in the ampulla of Vater causing obstructive jaundice: report of a case. Surg Today 2008;38:76–80.
Shapira MY, Muszkat M, Braunstein I, Gotsman I. Cooccurrence of hepatocellular carcinoma and lymphoma in patients with hepatitis C virus cirrhosis. J Clin Gastroenterol 2001;32:368–369.
Himoto T, Miyauchi Y, Nomura K, Fushitani T, Kurokohchi K, Masaki T, et al. Coexistence of splenic non-Hodgkin’s lymphoma with hepatocellular carcinoma in a patient with chronic hepatitis C. Dig Dis Sci 2006;51:70–76.
Lin A, Kadam JS, Bodenheimer HC, Leonard J, Joyce MA, Lake-Bakaar G. Concomitant diffuse large B-cell lymphoma and hepatocellular carcinoma in chronic hepatitis C virus liver disease: a study of two cases. J Med Virol 2008:80:1350–1353.
Quinn ER, Chan CH, Hadlock KG, Foung SK, Flint M, Levy S. The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis. Blood 2001;98:3745–3749.
Kataoka TR, Tsukamoto Y, Kanazawa N, Izumi T, Awata N, Nishizawa Y, et al. Concomitant hepatocellular carcinoma and non-Hodgkin’s lymphoma in a patient with nodular regenerative hyperplasia. Pathol Int 2006;56:279–282.
Sella A, Ro JY. Renal cell cancer: best recipient of tumor-totumor metastasis. Urology 1987;30:35–38.
Sullu Y, Donmez G, Kandemir B, Gun S. Renal cell carcinoma with non-Hodgkin’s lymphoma infiltration: A case report. Pathol Res Pract 2007:203:625–627.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Utsunomiya, T., Okamoto, M., Tsujita, E. et al. Hepatocellular carcinoma infiltrated with non-Hodgkin’s lymphoma: Report of a case. Surg Today 39, 1010–1012 (2009). https://doi.org/10.1007/s00595-009-3966-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00595-009-3966-0