Abstract
Numerous randomized trials have been published investigating the effectiveness of treatments for non-specific low-back pain (LBP) either by trials comparing interventions with a no-treatment group or comparing different interventions. In trials comparing two interventions, often no differences are found and it raises questions about the basic benefit of each treatment. To estimate the effect sizes of treatments for non-specific LBP compared to no-treatment comparison groups, we searched for randomized controlled trials from systematic reviews of treatment of non-specific LBP in the latest issue of the Cochrane Library, issue 2, 2005 and available databases until December 2005. Extracted data were effect sizes estimated as Standardized Mean Differences (SMD) and Relative Risk (RR) or data enabling calculation of effect sizes. For acute LBP, the effect size of non-steroidal anti-inflammatory drugs (NSAIDs) and manipulation were only modest (ES: 0.51 and 0.40, respectively) and there was no effect of exercise (ES: 0.07). For chronic LBP, acupuncture, behavioral therapy, exercise therapy, and NSAIDs had the largest effect sizes (SMD: 0.61, 0.57, and 0.52, and RR: 0.61, respectively), all with only a modest effect. Transcutaneous electric nerve stimulation and manipulation had small effect sizes (SMD: 0.22 and 0.35, respectively). As a conclusion, the effect of treatments for LBP is only small to moderate. Therefore, there is a dire need for developing more effective interventions.
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Introduction
Non-specific low-back pain (LBP) is by most physicians considered as a recurring, benign, and self-limiting condition, but for patients it is a painful and disabling experience for which they frequently demand treatment. Several treatments are available for LBP, such as analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), exercise, behavioral therapy, spinal manipulation, and acupuncture. Numerous randomized trials have been published investigating the effectiveness of treatments for non-specific LBP. However, there are important differences in how these trials have been conducted: Many trials assess the effect of combinations of different interventions; some trials compare interventions with no treatment or placebo, whereas others compare different interventions for non-specific LBP. In trials comparing two interventions, there is often no difference found between groups and it remains unclear if any of the interventions are effective or not and it raises questions about the basic benefit of each treatment.
Several systematic reviews have been published addressing the question of the effect of a particular treatment for LBP. Conclusions from many of these reviews are based on qualitative analysis. This type of analysis uses various levels of evidence (from “strong” to no “evidence”) regarding the effectiveness of a treatment taking into account the participants, interventions, controls, outcomes, and methodological quality of the original studies [80]. Quantitative analysis, on the other hand, is a statistical approach involving pooling data (meta-analysis) that provides an overall effect estimate, which allow direct comparing between effects of different treatments.
The objective of the present study was to synthesize the results of randomized controlled trials (RCT) for common LBP treatments comparing the interventions to placebo/sham or no-treatment comparison groups, to estimate a pooled effect size for each treatment, and compare them with each other.
Methods
Study selection
We searched for RCT from systematic reviews of treatment of acute and chronic non-specific LBP in the latest issue of the Cochrane Library, issue 2, 2005 and used Medline/Pubmed, Embase, Cinhal, and Amed to search for additional papers limiting the search from the time of the last search in each Cochrane review until December 2005. The following terms were used for the search: LBP (Mesh) or LBP (tw), placebo effect (Mesh). In addition, RCT keywords were used for the search: “LBP” and the name of the treatment of current interest (i.e., exercise, manipulation, behavioral treatment, NSAIDs, and acupuncture) [80].
Low-back pain was defined as pain located below the scapulas and above the cleft of the buttocks [81] and non-specific LBP was defined as back pain not attributable to a recognizable, known specific pathology (i.e., infection, tumors, osteoporosis, fracture, structural deformity, inflammatory disorder, radicular syndrome, or cauda equina syndrome) [87]. Three criteria defined relevant trials: (1) the trials should compared the treatment to a no-treatment comparison group, (2) the trials should investigate an unselected and general population, and (3) the treatment should be practiced and be available in several countries.
The no-treatment comparison groups included subjects receiving placebo, sham treatments, no treatment, or those on a waiting list. Waiting-list implied that the patients were waiting for a treatment for their back pain. Placebo was defined as a medicine which has no inherent pertinent pharmacologic activity, but which is effective by virtue of the factor of suggestion attendant upon its administration. Sham treatment was defined as procedures where medical personal goes through the motions without actually performing the treatment such as sham acupuncture for acupuncture or detuned Transcutaneous electric nerve stimulation (TENS). No treatment implied that the patients were not prescribed any drugs by the physician or recommended any treatment or home exercises for their back pain from any other medical personnel. They could, however, receive a booklet with advice about daily activities.
We looked separately at trials investigating acute and subacute/chronic LBP. Acute LBP was defined as duration of pain less than 6 weeks and the subacute/chronic condition more than 6 weeks.
Outcome measures
Outcomes were self-reported pain intensity and self-reported physical functioning. In the LBP literature, several outcome measures have been used to assess the construct of pain intensity [for example, 10 cm or 100 mm visual analogue scale (VAS), McGill Pain Questionnaire, and numeric (11, 21, or 101 points) rating scale (NRS)] [86]. LBP-specific functioning can also be measured with various instruments [for example, Oswestry Disability Index (0–100), Quebec Back Pain Disability Scale (0–100), and the 24-point Roland Morris Disability Questionnaire] [44]. We used the standardized mean difference (SMD) to estimate the treatment effect of the individual trials for similar constructs. This will allow direct comparison of studies, which used different measures of sufficiently similar constructs [19].
Data extraction
Data were extracted from the included trials separately both for acute and subacute/chronic LBP, and also for short-term (assessment closest to 6 weeks after randomization) and long-term (assessment between 6 and 12 months after randomization) follow-up. We extracted effect sizes estimated as SMD and Relative Risk (RR) or data for calculation of effect size. Cohen categorized effect size values as small (ES: 0.2–0.5), moderate (ES: 0.5–0.8), and large (ES: >0.8) [16] but it is uncertain how this applies to the field of LBP.
We calculated effect size from either continuous (mean, SD, and confidence interval) or dichotomous variables (number of patients with good/excellent response to treatment). For continuous variables effect size was calculated as SMD, which is defined as the differences in outcome measures between two groups divided by the SD of the of the control group, the SD of the treatment group, or the pooled SD [19, 41]. For dichotomous data the effect size was calculated as RR, where RR is the risk of an event in the treatment group divided by the risk of the event in the comparison group. If no data were available for estimating effect size, the author of the trial was contacted by E-mail, and if data were provided, these trials were also included. If variance data were not reported as SDs, they were calculated from the trial data using standard error of the mean (SE) or 95% confidence intervals. If variance data were not reported, SDs from other relevant studies were used, i.e., studies concerning the same treatment and the same condition (acute or chronic). The pooled SD of the treatment effects for each group from relevant studies was calculated using the following formula [19]:
where n is the number of participants in each treatment group, N the total number and SD1 and SD2 are standard deviations for the intervention group and control group, respectively [19]. The percentage of the SDpooled of the mean difference of change from relevant studies was used in studies with missing variance data [25].
The quality of the included trials was reported as assessed by the authors of the systematic Cochrane reviews. For the original articles published after the reviews, one of the authors of the present study (AK) assessed the quality according to the 11-item criteria list recommended in the method guidelines for systematic reviews of the Cochrane Back Review Group [80]. Some reviews used another criteria based on a list consisting of three items [38].
Analysis
A quantitative meta-analysis was performed in which the effect sizes (SMDs and RR) were pooled using a random effect model.
We assessed statistical heterogeneity using I 2 statistics and confidence intervals [34]. We present the effect sizes separately for dichotomous and continuous variables. For continuous variables, the pooled effect sizes for the treatments for the acute and chronic condition are presented. In addition, the effect sizes for the individual studies for each treatment for the chronic condition and short-term follow-up are presented.
Review Manager, Version 4.2 for Windows (Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2003) was used for the analyses.
Results
We included seven reviews from the latest issue of the Cochrane Library, issue 2, 2005, from which we included 41 trials of 228 (Tables 1, 2). An additional six trials were identified from the updated search in Pubmed/Medline, Embase, Cinhal, and Amed. Table 1 shows the number of trials included from the systematic reviews and the updated search. About 20% of the trials were included, ranging from 4 to 50%. In most cases, the reason for not including a trial was because one type of intervention was compared to another intervention and not to a no-treatment group.
Acute low-back pain
Table 3 describes the studies, which evaluated the effectiveness of treatments for acute LBP. The effect sizes of the individual studies and the pooled effect sizes are presented in Tables 4 and 5 and in Fig. 1. Unless otherwise noted, the effect sizes presented are calculated from continuous outcome measures. We included four studies on exercise therapy [13, 26, 50, 54], which were published between 1993 and 2005: the quality was high in two studies and low in two. Regarding short-term follow-up, the pooled effect sizes for pain relief and function were 0.07 (95% CI: −0.30 to 0.44) and 0.38 (95% CI: −0.40 to 1.16), respectively. For long-term follow-up, the corresponding figures were −0.04 (95% CI: −0.35 to 0.27) and −0.13 (95% CI: −0.35 to 0.09) (Table 4 and Fig. 1). Moreover, these studies were characterized by a high degree of heterogeneity (I 2 = 69.1%).
We included three studies on spinal manipulation [8, 29, 63], which were published from 1974 to 1988: one was of medium and two were of low quality. Measures of variance were missing in all three studies, and therefore we used SDs from other RCT concerning manipulation in patients with acute LBP [36, 88]. The pooled SDs of these two studies were 85 and 140% of the mean difference, respectively. For the calculations of effect size, we chose a SD of 112.5% of the difference in mean. We also performed a sensitivity analysis with SD values of 85 and 140% of the mean, applied on the studies without measurements of variations [8, 29, 63]. The pooled effect sizes for short-term pain-relief were 0.50 with SD at 85%, 0.33 with SD at 140%, and 0.40 (95% CI: −0.09 to 0.89) with SD at 112.5 (Table 4 and Fig. 1). The studies were homogeneous (I 2 = 10.7%).
Three studies on NSAIDs were included [5, 18, 71], which were published from 1994 to 2003: one of high quality and two of moderate quality. The pooled effect size for short-term pain relief was 0.51 (95% CI: 0.16 to 0.86) (Table 4 and Fig. 1), but the studies exhibited a high degree of heterogeneity (I 2 = 67.8%).
Four studies on muscle relaxants comparing non-benzodiazepines with placebo were included [6, 9, 47, 78]. They were published from 1979 to 2003: two were of high quality and two moderate quality. The pooled effect size was calculated from dichotomous variable, and was for pain short-term follow-up 0.52 (95% CI: 0.42 to 0.65) (Table 5). The studies were homogenous (I 2 = 0.0).
Chronic low-back pain
Table 6 describes the included studies for evaluation of the treatments for chronic LBP, the effect sizes are presented in Tables 6 and 7, in Figs. 1 and 2. We included six studies on exercise therapy [45, 64, 65, 69, 76, 91], which were published from 1981 to 2000: one was of medium and five of low quality. The pooled effect size was 0.52 (95% CI: −0.21 to 1.25) for short-term pain relief, and 0.25 (95% CI: −0.04 to 0.54) for long-term pain relief. For short- and long-term improvement in function, the effect sizes were 0.22 (95% CI: −0.07 to 0.51) and 0.13 (95% CI: −0.32 to 0.58), respectively. The studies had a high degree of heterogeneity (I 2 = 88.5%).
We included seven studies on behavioral treatment [49, 60, 70, 74–77], which were published from 1982 to 1993: one was of high, four of modest quality, and two of low quality. The effect sizes for short-term follow-up for pain relief were 0.57 (95% CI: 0.33 to 0.81) and 0.24 (95% CI: −0.01 to 0.49) for function. The studies were homogenous (I 2 = 0.0).
Five studies concerning manipulation were included [21, 61, 63, 73, 89]. The included studies were published from 1978 to 1995: four studies were of modest and one was of low quality. Measures of variance were not available for three studies [21, 63, 89] and, therefore, the variance measurements from the two other studies were used [61, 73]. The pooled SDs of these two studies were 60 and 130% of the mean difference, respectively. For the calculations of effect size, we chose a SD of 95% of the difference in mean. We also performed a sensitivity analysis with SD values of 60 and 130% of the mean, applied on the studies without measurements of variations [21, 63, 89]. The pooled effect sizes for short-term pain-relief were of 0.49 with SD at 60%, 0.19 with SD at 130%, and 0.35 (95% CI: −0.01 to 0.69) with SD at 95% of mean difference. The studies were moderately heterogeneous (I 2 = 50.7%).
Two studies [17, 53] were included on Transcutaneous Electrical Nerve Stimulation (TENS) [43], which were published in 1990 and 1993 and were of modest and low quality, respectively. The pooled effect size for short-term pain relief was small 0.19 (95% CI: −0.13 to 0.51). The studies were quite homogeneous (I 2 = 17.7%).
We included seven studies in acupuncture [12, 14, 42, 46, 55, 57, 72], which were published from 1980 to 2002 and most were of moderate to high quality. The pooled effect size for short-term pain relief was modest 0.61 (95% CI: 0.41 to 0.81). The studies were homogenous (I 2 = 0.0).
We included three studies evaluating the effect of benzodiazepines [2, 66, 85]. They were published in 1990 and 1992 and were considered to be of moderate quality. The effect size was moderate for short-term pain relief RR 0.82 (95% CI: 0.72–0.94) (Table 6). The studies were homogenous (I 2 = 0.0).
We considered four studies on the effect of NSAIDs on chronic LBP [10, 15, 40], but one was excluded because there was no data available for estimating effect size [10]. They were published from 2003 to 2004 and were of high quality. The pooled effect size for pain was moderate RR 0.61 (95% CI: 0.50 to 0.74) for short-term follow up.
Discussion
The purpose of the present study was to investigate the effect sizes of treatments for non-specific LBP in randomized controlled studies comparing treatment with no treatment. In general, only a few studies of all the included RCT in the systematic reviews of the Cochrane Library, issue 2, 2005, compared treatments with no treatment (Fig. 1). The results are sobering as there are only modest effect sizes, if any, for short-term pain relief.
For the acute condition the effect size of NSAID and manipulation were only modest, there was no effect of exercise, and function and long-term follow-up were missing from most studies. Our results are in accordance with “the European Guidelines for acute LBP” which recommend NSAID and consideration of a short course of manipulation if the patients do not return to normal activities [20].
For chronic LBP, acupuncture and behavioral therapy had the largest effect size, followed by exercise and NSAID, although, all with only a modest effect. TENS and manipulation had small effect sizes. Only exercise and behavioral therapy measured function, but demonstrated scarcely any effect and data on long-term follow-up were missing.
“The European Guidelines of the management of chronic LBP” [1] recommends behavioral therapy, exercise, and a brief educational intervention, in addition to a brief treatment with NSAID and muscle relaxants. Additionally, they also suggest a short course of manipulation as a treatment option. Although acupuncture is not included in the European guideline’s recommendations, we found that acupuncture had a modest effect size, when compared to placebo or no-treatment groups.
Supervised exercise is recommended as the first line treatment in the management of chronic LBP, without any recommendations on the specific type of exercises [1]. The definition of exercise is wide and defined as “a series of specific movements with the aim of training or developing the body by a routine practice or as physical training to promote good physical health” [32], and accordingly the included studies in the present study concerning exercise contain all kind of exercises and different combinations of exercise programs. We based our results on quantitative analysis, in order to produce a single estimate of a treatment effect [19]. However, to do this in a meaningful way, heterogeneity must be taken into account. Heterogeneity concerns the variation in results across studies, which might be the result of differences in patient selection, type of treatments and combinations of these, durations of treatment, and more. The level of heterogeneity is calculated by chi-square test and is quantified by the I 2-value, which describes the percentage of the total variation across studies that are due to heterogeneity rather than chance. We demonstrated a high level of heterogeneity for exercise trials, and although it seems reasonable to compare all kinds of exercise-programs, the limitation is that it is not possible to calculate a pooled effect size. So, for achieving a consistence and homogenous measure of the effect of exercises, it seems suitable to compare studies with the same exercise programs or use advance statistical methods to explore these characteristics [32]. The heterogeneity for manipulation was also high, which might be explained by different manipulations methods and different populations.
It might be surprising that we only found modest effect of the most common treatments for non-specific LBP. For acute LBP, the low-effect sizes might be explained by the fact that it is usually a self-limiting condition with a recovery rate at 90% within 6 weeks [20, 37]. Concerning chronic non-specific LBP, the definition of the diagnosis “chronic non-specific low back pain” is not defined as a clinical entity and diagnosis, but rather a symptom in patients with very different stages of impairment and disability without knowing the specific causes of the pain [1]. This implies that we compare effects of treatments for a condition without a specific diagnostic test, based on patient’s rating of pain, with different unspecific radiological findings and where the prognosis is influenced by psycho–social and work related factors. This is a serious limitation of the study, which may contribute to the modest effect sizes, and it emphasizes the need of defining appropriate sub-classifications of non-specific LBP.
Most RCT for treatments of LBP compare combinations of different interventions with either one intervention or another combination of interventions [4, 7, 51], and only a small part (about 20%) compare treatments with a no-treatment group (Table 1). This is interesting as it would be natural first to investigate the basic benefit of treatments and then compare them to each other. The purpose of the present study was to investigate the basic benefit with the consequence that only a small part of trials from each systematic review would be included (Tables 1, 2) and some treatments in general use would be excluded. Although this limits the generalization of the result, it brings into focus the importance of no-treatment controlled trials for investigating the pure effect of treatments for non-specific low-back pain. However, we are aware of the multitude of difficulties in carrying out no-treatment controlled trials, particularly within surgery.
Although surgery for degenerative conditions affecting the lumbar spine is a common type of treatment, it was excluded from the present study as most RCT compare different surgical techniques. To our knowledge, the only exception is the study by Fritzell et al. [22] comparing lumbar fusion with a no-treatment group. Most patients with chronic low-back pain who are referred to a surgical clinic have been through several non-surgical treatments, inclusive exercises, and they often demand surgical treatment. Hence, it might be a hard task for the physician to persuade these patients to be enrolled into a RCT, since there is a risk they will be randomized to the no-treatment group.
Another limitation is the quality of the included studies. Generally, they ranged from 3 to 7 according to the 11-item criteria list, with a few exceptions of 9 and 11, both for acute and chronic LBP (Tables 3 and 8). In addition, in several studies, mostly concerning manipulation, the variability of the effect estimate was not reported and for this reason we used the SD from other studies. Although, we performed sensitivity analyses, this is a limitation that calls for a cautious interpretation of the results.
Overall, the follow-up in most of the studies was insufficient. Exercise therapy has short and long-term follow-ups both for the acute and the chronic condition, but apart from this treatment there is a lack of long-term follow up. However, it is likely that long-term follow-up would not change the conclusion in current study, as the effect sizes in general were small at short-term follow-up and would most probably not have changed at long-term follow-up.
Outcomes measurements in the field of LBP are pain and function measured by psychometric scales. In the present study, there were several different scales both for pain and function. Although the measurements can be standardized by calculating effect size or by rescaling individual trials outcome for pain and functioning from 0 to 100, comparison of trials would be more easy and precise by using the same scales as recommended by Bombardier et al. [11].
It is common to accept co-interventions in RCT and it might be difficult to carry out RCT not allowing patients to visit other health care providers. However, co-interventions contribute to blur the effects of the treatments in the RCT, so that is the reason for our decision to exclude trials where patients were allowed to have co-interventions [47, 58, 67].
In conclusion, the effect sizes for the pure benefit of treatments of LBP that are compared to no-treatment groups were small to moderate for both the acute and chronic conditions. There was a lack of long-term follow up for pain and function and the quality of the studies were low to moderate. For increasing our knowledge about treatments of non-specific LBP, there is still a need to develop more effective interventions.
References
Airaksinen O, Brox JI, Cedraschi C, Hildebrandt J, Klaber-Moffett J, Kovacs F, Mannion AF, Reis S, Staal JB, Ursin H, Zanoli G (2006) Chapter 4. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J 15(Suppl 2):S192–S300
Arbus L, Fajadet B, Aubert D, Morre M, Goldfinger E (1990) Activity of tetrazepam in low back pain. Clin Trials J 27:58–67
Assendelft WJ, Morton SC, Yu EI, Suttorp MJ, Shekelle PG (2004) Spinal manipulative therapy for low back pain. Cochrane Database Syst Rev CD000447
Aure OF, Nilsen JH, Vasseljen O (2003) Manual therapy and exercise therapy in patients with chronic low back pain: a randomized, controlled trial with 1-year follow-up. Spine 28:525–531; discussion 531–522
Babej-Dolle R, Freytag S, Eckmeyer J, Zerle G, Schinzel S, Schmeider G, Stankov G (1994) Parenteral dipyrone versus diclofenac and placebo in patients with acute lumbago or sciatic pain: randomized observer-blind multicenter study. Int J Clin Pharmacol Ther 32:204–209
Barrata R (1982) A double-blind study of cyclobenzaprine and placebo in the treatment of acute musculoskeletal conditions of the low back pain. Curr Ther Res 32:646–652
Bendix AF, Bendix T, Lund C, Kirkbak S, Ostenfeld S (1997) Comparison of three intensive programs for chronic low back pain patients: a prospective, randomized, observer-blinded study with one- year follow-up. Scand J Rehabil Med 29:81–89
Bergquist-Ullman M, Larsson U (1977) Acute low back pain in industry. A controlled prospective study with special reference to therapy and confounding factors. Acta Orthop Scand 1–117
Berry H, Hutchinson D (1988) A multicenter placebo-controlled study in general practice to evaluate the efficacy and safety of tizanidine in acute low-back pain. J Int Med Res 16:75–82
Birbara CA, Puopolo AD, Munoz DR, Sheldon EA, Mangione A, Bohidar NR, Geba GP (2003) Treatment of chronic low back pain with etoricoxib, a new cyclo-oxygenase-2 selective inhibitor: improvement in pain and disability—a randomized, placebo-controlled, 3-month trial. J Pain 4:307–315
Bombardier C (2000) Outcome assessments in the evaluation of treatment of spinal disorders: summary and general recommendations. Spine 25:3100–3103
Carlsson CP, Sjolund BH (2001) Acupuncture for chronic low back pain: a randomized placebo-controlled study with long-term follow-up. Clin J Pain 17:296–305
Chok B, Lee R, Latimer J, Tan SB (1999) Endurance training of the trunk extensor muscles in people with subacute low back pain. Phys Ther 79:1032–1042
Coan RM, Wong G, Ku SL, Chan YC, Wang L, Ozer FT, Coan PL (1980) The acupuncture treatment of low back pain: a randomized controlled study. Am J Chin Med 8:181–189
Coats TL, Borenstein DG, Nangia NK, Brown MT (2004) Effects of valdecoxib in the treatment of chronic low back pain: results of a randomized, placebo-controlled trial. Clin Ther 26:1249–1260
Cohen J (1977) Statistical power analysis for the behavioral sciences. Academic, New York
Deyo RA, Walsh NE, Martin DC, Schoenfeld LS, Ramamurthy S (1990) A controlled trial of transcutaneous electrical nerve stimulation (TENS) and exercise for chronic low back pain. N Engl J Med 322:1627–1634
Dreiser RL, Marty M, Ionescu E, Gold M, Liu JH (2003) Relief of acute low back pain with diclofenac-K 12.5 mg tablets: a flexible dose, ibuprofen 200 mg and placebo-controlled clinical trial. Int J Clin Pharmacol Ther 41:375–385
Egger M, Smith G, Altman DG (2001) Systematic reviews in health care. Meta-analysis in context. BMJ Books, London
European Commission COST B13 Management Committee (2002) European guidelines for the management of low back pain. Acta Orthop Scand Suppl 73:20–25
Evans DP, Burke MS, Lloyd KN, Roberts EE, Roberts GM (1978) Lumbar spinal manipulation on trial. Part I—clinical assessment. Rheumatol Rehabil 17:46–53
Fritzell P, Hagg O, Wessberg P, Nordwall A (2001) 2001 Volvo award winner in clinical studies: lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish lumbar spine study group. Spine 26:2521–2532; discussion 2532–2524
Furlan AD, Brosseau L, Imamura M, Irvin E (2002) Massage for low back pain. Cochrane Database Syst Rev CD001929
Furlan AD, van Tulder MW, Cherkin DC, Tsukayama H, Lao L, Koes BW, Berman BM (2005) Acupuncture and dry-needling for low back pain. Cochrane Database Syst Rev CD001351
Furukawa TA, Barbui C, Cipriani A, Brambilla P, Watanabe N (2006) Imputing missing standard deviations in meta-analyses can provide accurate results. J Clin Epidemiol 59:7–10
Faas A, Chavannes AW, van Eijk JT, Gubbels JW (1993) A randomized, placebo-controlled trial of exercise therapy in patients with acute low back pain. Spine 18:1388–1395
Gibson JN, Grant IC, Waddell G (2000) Surgery for lumbar disc prolapse. Cochrane Database Syst Rev CD001350
Gibson JN, Waddell G, Grant IC (2000) Surgery for degenerative lumbar spondylosis. Cochrane Database Syst Rev CD001352
Glover JR, Morris JG, Khosla T (1974) Back pain: a randomized clinical trial of rotational manipulation of the trunk. Br J Ind Med 31:59–64
Guzman J, Esmail R, Karjalainen K, Malmivaara A, Irvin E, Bombardier C (2002) Multidisciplinary bio-psycho-social rehabilitation for chronic low back pain. Cochrane Database Syst Rev CD000963
Hagen K, Hilde G, Jamtvedt G, Winnem M (2004) Bed rest for acute low-back pain and sciatica. Cochrane Database Syst Rev CD001254
Hayden JA, van Tulder MW, Malmivaara AV, Koes BW (2005) Meta-analysis: exercise therapy for nonspecific low back pain. Ann Intern Med 142:765–775
Heymans M, Tulder M, Esmail R, Bombardier C, Koes B (2004) Back schools for non-specific low-back pain. Cochrane Database Syst Rev CD000261
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560
Hilde G, Hagen KB, Jamtvedt G, Winnem M (2002) Advice to stay active as a single treatment for low back pain and sciatica. Cochrane Database Syst Rev CD003632
Hurley DA, McDonough SM, Dempster M, Moore AP, Baxter GD (2004) A randomized clinical trial of manipulative therapy and interferential therapy for acute low back pain. Spine 29:2207–2216
Indahl A (2004) Low back pain: diagnosis, treatment, and prognosis. Scand J Rheumatol 33:199–209
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12
Karjalainen K, Malmivaara A, van Tulder M, Roine R, Jauhiainen M, Hurri H, Koes B (2003) Multidisciplinary biopsychosocial rehabilitation for subacute low back pain among working age adults. Cochrane Database Syst Rev CD002193
Katz N, Ju WD, Krupa DA, Sperling RS, Bozalis Rodgers D, Gertz BJ, Gimbel J, Coleman S, Fisher C, Nabizadeh S, Borenstein D (2003) Efficacy and safety of rofecoxib in patients with chronic low back pain: results from two 4-week, randomized, placebo-controlled, parallel-group, double-blind trials. Spine 28:851–858; discussion 859
Kazis LE, Anderson JJ, Meenan RF (1989) Effect sizes for interpreting changes in health status. Med Care 27:S178–S189
Kerr DP, Walsh DM, Baxter GD (2001) A study of the use of acupuncture in physiotherapy. Complement Ther Med 9:21–27
Khadilkar A, Milne S, Brosseau L, Wells G, Tugwell P, Robinson V, Shea B, Saginur M (2005) Transcutaneous electrical nerve stimulation for the treatment of chronic low back pain: a systematic review. Spine 30:2657–2666
Kopec JA (2000) Measuring functional outcomes in persons with back pain: a review of back-specific questionnaires. Spine 25:3110–3114
Kuukkanen T, Malkia E (2000) Effects of a three-month therapeutic exercise programme on flexibility in subjects with low back pain. Physiother Res Int 5:46–61
Leibing E, Leonhardt U, Koster G, Goerlitz A, Rosenfeldt JA, Hilgers R, Ramadori G (2002) Acupuncture treatment of chronic low-back pain—a randomized, blinded, placebo-controlled trial with 9-month follow-up. Pain 96:189–196
Lepisto P (1979) A comparative trial of DS 103–282 and placebo in the treatment of acute skeletal muscle spasms due to disorders of the back. Ther Res 26:454–459
Licciardone JC, Stoll ST, Fulda KG, Russo DP, Siu J, Winn W, Swift J Jr (2003) Osteopathic manipulative treatment for chronic low back pain: a randomized controlled trial. Spine 28:1355–1362
Linton SJ, Bradley LA, Jensen I, Spangfort E, Sundell L (1989) The secondary prevention of low back pain: a controlled study with follow-up. Pain 36:197–207
Malmivaara A, Hakkinen U, Aro T, Heinrichs ML, Koskenniemi L, Kuosma E, Lappi S, Paloheimo R, Servo C, Vaaranen V, et al (1995) The treatment of acute low back pain—bed rest, exercises, or ordinary activity? N Engl J Med 332:351–355
Mannion AF, Junge A, Taimela S, Muntener M, Lorenzo K, Dvorak J (2001) Active therapy for chronic low back pain: part 3. Factors influencing self-rated disability and its change following therapy. Spine 26:920–929
Mannion AF, Muntener M, Taimela S, Dvorak J (1999) A randomized clinical trial of three active therapies for chronic low back pain. Spine 24:2435–2448
Marchand S, Charest J, Li J, Chenard JR, Lavignolle B, Laurencelle L (1993) Is TENS purely a placebo effect? A controlled study on chronic low back pain. Pain 54:99–106
Mayer JM, Ralph L, Look M, Erasala GN, Verna JL, Matheson LN, Mooney V (2005) Treating acute low back pain with continuous low-level heat wrap therapy and/or exercise: a randomized controlled trial. Spine J 5:395–403
Mendelson G, Selwood TS, Kranz H, Loh TS, Kidson MA, Scott DS (1983) Acupuncture treatment of chronic back pain. A double-blind placebo-controlled trial. Am J Med 74:49–55
Mitchell RI, Carmen GM (1990) Results of a multicenter trial using an intensive active exercise program for the treatment of acute soft tissue and back injuries. Spine 15:514–521
Molsberger AF, Mau J, Pawelec DB, Winkler J (2002) Does acupuncture improve the orthopedic management of chronic low back pain—a randomized, blinded, controlled trial with 3 months follow up. Pain 99:579–587
Nelemans PJ, de Bie RA, de Vet HC, Sturmans F (2000) Injection therapy for subacute and chronic benign low back pain. Cochrane Database Syst Rev CD001824
Niemisto L, Lahtinen-Suopanki T, Rissanen P, Lindgren KA, Sarna S, Hurri H (2003) A randomized trial of combined manipulation, stabilizing exercises, and physician consultation compared to physician consultation alone for chronic low back pain. Spine 28:2185–2191
Nouwen A (1983) EMG biofeedback used to reduce standing levels of paraspinal muscle tension in chronic low back pain. Pain 17:353–360
Ongley MJ, Klein RG, Dorman TA, Eek BC, Hubert LJ (1987) A new approach to the treatment of chronic low back pain. Lancet 2:143–146
Pallay RM, Seger W, Adler JL, Ettlinger RE, Quaidoo EA, Lipetz R, O’Brien K, Mucciola L, Skalky CS, Petruschke RA, Bohidar NR, Geba GP (2004) Etoricoxib reduced pain and disability and improved quality of life in patients with chronic low back pain: a 3 month, randomized, controlled trial. Scand J Rheumatol 33:257–266
Postacchini F, Facchini M, Palieri P (1988) Efficacy of various forms of conservative treatment in low back pain. A comparative study. Neuro Orthop 6:28–35
Preyde M (2000) Effectiveness of massage therapy for subacute low-back pain: a randomized controlled trial. CMAJ 162:1815–1820
Risch SV, Norvell NK, Pollock ML, Risch ED, Langer H, Fulton M, Graves JE, Leggett SH (1993) Lumbar strengthening in chronic low back pain patients. Physiologic and psychological benefits. Spine 18:232–238
Salzmann E, Pforringer W, Paal G, et al (1992) Treatment of chronic low-back syndrome with tetrazepamin a placebo controlled double-blind trial. J Drug Dev 4:219–228
Schonstein E, Kenny DT, Keating J, Koes BW (2003) Work conditioning, work hardening and functional restoration for workers with back and neck pain. Cochrane Database Syst Rev CD001822
Sherman KJ, Cherkin DC, Erro J, Miglioretti DL, Deyo RA (2005) Comparing yoga, exercise, and a self-care book for chronic low back pain: a randomized, controlled trial. Ann Intern Med 143:849–856
Soukup MG, Glomsrod B, Lonn JH, Bo K, Larsen S (1999) The effect of a Mensendieck exercise program as secondary prophylaxis for recurrent low back pain. A randomized, controlled trial with 12-month follow-up. Spine 24:1585–1591; discussion 1592
Stuckey SJ, Jacobs A, Goldfarb J (1986) EMG biofeedback training, relaxation training, and placebo for the relief of chronic back pain. Percept Mot Skills 63:1023–1036
Szpalski M, Hayez JP (1994) Objective functional assessment of the efficacy of tenoxicam in the treatment of acute low back pain. A double-blind placebo-controlled study. Br J Rheumatol 33:74–78
Thomas M, Lundberg T (1994) Importance of modes of acupuncture in the treatment of chronic nociceptive low back pain. Acta Anaesthesiol Scand 38:63–69
Triano JJ, McGregor M, Hondras MA, Brennan PC (1995) Manipulative therapy versus education programs in chronic low back pain. Spine 20:948–955
Turner JA, Chapman CR (1982) Psychological interventions for chronic pain: a critical review I. Relaxation training and biofeedback. Pain 12:1–21
Turner JA, Clancy S (1988) Comparison of operant behavioral and cognitive-behavioral group treatment for chronic low back pain. J Consult Clin Psychol 56:261–266
Turner JA, Clancy S, McQuade KJ, Cardenas DD (1990) Effectiveness of behavioral therapy for chronic low back pain: a component analysis. J Consult Clin Psychol 58:573–579
Turner JA, Jensen MP (1993) Efficacy of cognitive therapy for chronic low back pain. Pain 52:169–177
Tuzun F, Unalan H, Oner N, Ozguzel H, Kirazli Y, Icagasioglu A, Kuran B, Tuzun S, Basar G (2003) Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain. Joint Bone Spine 70:356–361
Urrutia G, Burton AK, Morral A, Bonfill X, Zanoli G (2004) Neuroreflexotherapy for non-specific low-back pain. Cochrane Database Syst Rev CD003009
van Tulder M, Furlan A, Bombardier C, Bouter L (2003) Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine 28:1290–1299
van Tulder M, Malmivaara A, Esmail R, Koes B (2002) Exercise therapy for low back pain: a systematic review within the framework of the cochrane collaboration back review group. Spine 25:2784–2796
van Tulder MW, Jellema P, van Poppel MN, Nachemson AL, Bouter LM (2000) Lumbar supports for prevention and treatment of low back pain. Cochrane Database Syst Rev CD001823
van Tulder MW, Ostelo R, Vlaeyen JW, Linton SJ, Morley SJ, Assendelft WJ (2000) Behavioral treatment for chronic low back pain: a systematic review within the framework of the cochrane back review group. Spine 25:2688–2699
van Tulder MW, Scholten RJ, Koes BW, Deyo RA (2000) Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev CD000396
van Tulder MW, Touray T, Furlan AD, Solway S, Bouter LM (2003) Muscle relaxants for non-specific low back pain. Cochrane Database Syst Rev CD004252
Von Korff M, Jensen MP, Karoly P (2000) Assessing global pain severity by self-report in clinical and health services research. Spine 25:3140–3151
Waddell G (1987) 1987 Volvo award in clinical sciences. A new clinical model for the treatment of low-back pain. Spine 12:632–644
Wand BM, Bird C, McAuley JH, Dore CJ, MacDowell M, De Souza LH (2004) Early intervention for the management of acute low back pain: a single-blind randomized controlled trial of biopsychosocial education, manual therapy, and exercise. Spine 29:2350–2356
Waagen G, Haldeman S, Cook G, Lopez D, DeBoer K (1986) Short term trial of chiropractic adjustments for the relief of chronic low back pain. Manual Med 2:63–67
Yelland MJ, Mar C, Pirozzo S, Schoene ML, Vercoe P (2004) Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev CD004059
Zylbergold R, Piper M (1981) Lumbar disc disease: comparative analysis of physical therapy. Arch Phys Med Rehabil 62:176–179
Acknowledgment
Dr. Hayden was supported by a Postdoctoral Fellowship Award from the Canadian Institutes of Health Research and the Canadian Chiropractic Research Foundation.
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Keller, A., Hayden, J., Bombardier, C. et al. Effect sizes of non-surgical treatments of non-specific low-back pain. Eur Spine J 16, 1776–1788 (2007). https://doi.org/10.1007/s00586-007-0379-x
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DOI: https://doi.org/10.1007/s00586-007-0379-x