Abstract.
Ductal structures of the adult pancreas contain multipotent stem cells that, under controlled in vitro conditions, are able to self-renew and differentiate into functional islets of Langerhans. In vitro-generated islets, whether derived from stem cells of human, porcine, or mouse origin, exhibit temporal changes in mRNA transcripts for islet-associated markers as well as regulated insulin responses following glucose challenge. When in vitro-generated mouse islets were implanted into diabetic mice, neovascularization of the implant material occurred, followed by reversal of insulin-dependent diabetes. The possibility of growing functional islets from adult stem cells provides new opportunities to produce large numbers of islets, even autologous islets, for use as implants.
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Received: February 19, 2002 / Accepted: March 8, 2002
Offprint requests to: A.B. Peck
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Peck, A., Cornelius, J., Schatz, D. et al. Generation of islets of Langerhans from adult pancreatic stem cells. J Hep Bil Pancr Surg 9, 704–709 (2002). https://doi.org/10.1007/s005340200097
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DOI: https://doi.org/10.1007/s005340200097