Abstract
The growth of short children with chronic renal failure (CRF) and renal transplants was assessed over 10 years following entry into a 1-year trial of recombinant human growth hormone (rhGH) therapy. Patients were divided into three groups: 6 prepubertal patients with CRF (group 1), mean (range) age at start of trial 7.7 (5.0–10.4) years; 6 prepubertal patients with renal transplants (group 2), age 11.9 (9.5–14.6) years; and 6 pubertal patients with renal transplants (group 3), age 15.6 (14.1–18.3) years. In group 1, the mean (range) height standard deviation score (Ht SDS) increased from –2.9 (–3.7 to –2.2) to –1.9 (–2.9 to –0.5) over 4.0 (0.3–9.1) years of rhGH (P=0.04), and was –1.6 (–2.9 to –0.4) after 10 years of follow-up (NS). In group 2 Ht SDS increased from –3.3 (–4.5 to –1.9) to –2.9 (–5.4 to –0.5) over 2.7 (1.0–6.0) years and was –3.0 (–6.3 to –0.1) at final height (NS). In group 3 Ht SDS increased from –3.4 (–4.3 to –2.6) to –3.0 (–3.4 to –2.2) over 1.4 (0.2–2.3) years (NS) and was –2.5 (–3.0 to –1.9) at final height (P=0.03 from stopping rhGH to final height). Final height was attained in 13 patients, in whom Ht SDS increased from –3.2 (–4.3 to –1.9) to –2.6 (–3.9 to –0.5) on rhGH (P=0.004) and to –2.2 (–4.4 to –0.1) after stopping treatment (P=0.04). Four patients died, 2 have chronic hepatitis C, and 1 has had surgery for parathyroid adenomata. In conclusion, the majority of patients had an improvement in Ht SDS while on rhGH, which was maintained after stopping treatment.
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Received: 18 November 1998 / Revised: 10 August 1999 / Accepted: 13 August 1999
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Rees, L., Ward, G. & Rigden, S. Growth over 10 years following a 1-year trial of growth hormone therapy. Pediatr Nephrol 14, 309–314 (2000). https://doi.org/10.1007/s004670050765
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DOI: https://doi.org/10.1007/s004670050765