Abstract
This retrospective study reports seven children and three young adults (aged 11–30 years) who suffered from Wegener granulomatosis. Nine represent consecutive patients admitted to the Division of Nephrology over a period of 23 years. All patients had respiratory tract symptoms and renal involvement on admission. In several patients infiltrates on chest X-ray developed within 2 weeks of onset of symptoms. All patients survived. The median observation period was 9 years (range 13 months to 23 years). One patient progressed to end-stage renal disease. Nine patients initially received cyclophosphamide and steroids. After a median period of 9 months (range 6–31 months) the cyclophosphamide was replaced by azathioprine. Relapses occurred after a median of 28 months (range 4–120 months) in 80% of patients, in six of the eight patients causing a definite decrease in kidney function. We believe that early diagnosis and initiation of therapy reduce the extent of organ damage. Since relapses are frequent, these patients should be evaluated frequently.
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Received: 18 December 1997 / Revised: 1 December 1998 / Accepted: 2 December 1998
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Stegmayr, B., Gothefors, L., Malmer, B. et al. Wegener granulomatosis in children and young adults . Pediatr Nephrol 14, 208–213 (2000). https://doi.org/10.1007/s004670050043
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DOI: https://doi.org/10.1007/s004670050043