Abstract
Background: Surgery can suppress immune function and facilitate tumor growth. Several studies have demonstrated better preservation of immune function following laparoscopic procedures. Our laboratory has also shown that tumors are more easily established and grow larger after sham laparotomy than after pneumoperitoneum in mice. The purpose of this study was to determine if the previously reported differences in tumor establishment and growth would persist in the setting of an intraabdominal manipulation.
Methods: Syngeneic mice received intradermal injections of tumor cells and underwent either an open or laparoscopic cecal resection. In study 1, the incidence of tumor development was observed after a low dose inoculum; whereas in study 2, tumor mass was compared on postoperative day 12 after a high-dose inoculum.
Results: In study 1, tumors were established in 5% of control mice, 30% of laparoscopy mice, and 83% of open surgery mice (p < 0.01 for all comparisons). In study 2, open surgery group tumors were 1.5 times as large as laparoscopy group tumors (p < 0.01), which were 1.5 times as large as control group tumors (p < 0.02).
Conclusion: We conclude that tumors are more easily established and grow larger after open laparoscopic bowel resection in mice.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Author information
Authors and Affiliations
Additional information
Received: 27 October 1997/Accepted: 19 January 1998
Rights and permissions
About this article
Cite this article
Allendorf, J., Bessler, M., Horvath, K. et al. Increased tumor establishment and growth after open vs laparoscopic bowel resection in mice. Surg Endosc 12, 1035–1038 (1998). https://doi.org/10.1007/s004649900775
Published:
Issue Date:
DOI: https://doi.org/10.1007/s004649900775