Abstract
Background: Numerous experimental and clinical investigations indicate that the mononuclear phagocyte system (MPS) has a relevant function in terms of physiological defense against tumor metastasis and bacterial infection. Consequently, a point of major interest is the influence of surgical techniques on the MPS function.
Method: The model investigation examines the phagocytosis activity of the rat's MPS during conventional fundoplication (group 1, n= 10), laparoscopic fundoplication using a pneumoperitoneum (group 2, n= 10), and gasless laparoscopic fundoplication (group 3, n= 10). The MPS function is evaluated by an intravascular carbon clearance test (G. Biozzi).
Results: The fastest carbon elimination half-life was found in group 3. By way of contrast, there was a significant increase of carbon half-life in group 2 (p < 0.005). Even group 1 caused less MPS depression (p < 0.1) than group 2.
Conclusion: Gasless laparoscopic procedures have a favorable effect on phagocytosis activity. The CO2 pneumoperitoneum seems to be the main reason for a decreased antigen elimination in laparoscopic treatments.
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Received: 8 December 1996/Accepted: 20 February 1997
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Gutt, C., Heinz, P., Kaps, W. et al. The phagocytosis activity during conventional and laparoscopic operations in the rat . Surg Endosc 11, 899–901 (1997). https://doi.org/10.1007/s004649900482
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DOI: https://doi.org/10.1007/s004649900482