Avoid common mistakes on your manuscript.
I read with interest the original article by Petter-Puchner et al. [1]. In it, the authors evaluated 20 Sprague-Dawley rats to study porcine small intestine submucosa implants randomizing sealant or sutures. Abscedation, encapsulation, and putrid seroma were observed in all samples; SIS was not detectable after 17 days.
I wish to point out the following considerations:
-
Porcine small intestine submucosa has a wide literature [2] with many experimental and clinical data and these adverse effects are not reported.
-
The study was based only on a limited sample of 20 rats.
-
Experiments were not repeated.
-
There was not a control group (it is not possible to have one of the two randomized group serving as control).
-
All samples had extensive infectious problems (in scientific models, 100% value is sometimes caused by methodological errors).
-
There are too many results totally discordant from the rest of the literature.
In summary, I think this study should be redone with a control group with polypropylene because there is a basic methodology problem.
References
Petter-Puchner AH, Fortelny RH, Mittermayr R, Walder N, Ohlinger W, Redl H (2006) Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair. Surg Endosc 20: 942–946
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R (2002) Morphologic study of small intestinal submucosa as a body wall repair device. J Surg Res 103: 190–202
Catena F, Ansaloni L, Leone A, De Cataldis A, Gagliardi S, Gazzotti F, Peruzzi S, Agrusti S, D’Alessandro L, Taffurelli M (2005) Lichtenstein repair of inguinal hernia with Surgisis inguinal hernia matrix soft-tissue graft in immunodepressed patients. Hernia 9: 29–31
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Catena, F., Ansaloni, L., D’Alessandro, L. et al. Adverse effects of porcine small intestine submucosa (SIS) implants in experimental ventral hernia repair. Surg Endosc 21, 690 (2007). https://doi.org/10.1007/s00464-006-9110-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00464-006-9110-y