Abstract
We report the analysis of the distribution of the C677T mutation on the methylenetetrahydrofolate reductase (MTHFR) gene in prenatally diagnosed neural tube defects (NTD) cases and controls. In contrast to previous reports, we found the same distribution in fetuses with NTD and controls, which suggests that the MTHFR C677T mutation cannot be regarded as a genetic risk factor for NTD.
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Received: 23 April 1997 / Accepted: 28 May 1997
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Mornet, E., Muller, F., Lenvoisé-Furet, A. et al. Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects. Hum Genet 100, 512–514 (1997). https://doi.org/10.1007/s004390050544
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DOI: https://doi.org/10.1007/s004390050544