Abstract
A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hes-peridin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.
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Abbreviations
- DMBA:
-
7,12-dimethylbenz[a]anthracene
- TPA:
-
12-O-tetra-decanoyl-13-phorbol acetate
- FOR:
-
free oxygen radicals
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Berkarda, B., Koyuncu, H., Soybir, G. et al. Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin. Res. Exp. Med. 198, 93–99 (1998). https://doi.org/10.1007/s004330050093
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DOI: https://doi.org/10.1007/s004330050093