Abstract
Despite the introduction of universal newborn hearing screening (UNHS), unilateral hearing loss (UHL) is sometimes recognized late. This diagnostic delay has adverse repercussions, given the importance of binaural hearing for the development of normal auditory processing. It is incorrect to maintain that unilateral hearing is the minimum requirement for adequate speech development and that hearing aid provision is consequently unnecessary. In our retrospective study, hearing aid provision resulted in improved directional and selective hearing (quiet and noisy environments) and, compared with their chronically ill counterparts, the children in our study displayed superior health-related quality of life (HRQoL) scores in all areas. On the basis of the results, the authors conclude that even mild hearing losses (from an auditory threshold of 30 to 40 dB) should have the opportunity for hearing aid provision. A selective literature review was conducted in PubMed and textbooks and with reference to national and international guidelines. Early diagnosis and treatment of UHL have a positive effect on verbal-cognitive, linguistic, communicative, and socio-emotional development, as demonstrated by neurophysiological studies. Among the treatment modalities with differing effects on the quality of binaural hearing, cochlear implants are now used increasingly in children with hearing loss bordering on deafness.
Conclusion: Published evidence and clinical experience support early diagnosis and treatment. Wherever feasible, hearing aid provision before or at the end of the first year of life is recommended for children with UHL.
What is Known: • Almost 30 years ago, poor academic performance was reported in children with unilateral hearing loss (UHL). • Despite improvements in treatment options, it is traditionally held that unilateral hearing is the minimum requirement for adequate speech development and hearing aid provision is unnecessary. |
What is New: • Academic and behavioral deficits in children with UHL may be mediated by deficiencies in the default mode network. • Published evidence supports the recommendation for hearing aid provision before or at the end of the first year of life in children with UHL. |
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Introduction
Binaural hearing is important for hearing, speech, and general child development, as international studies have demonstrated for decades. In routine clinical practice, however, these insights are not reflected in the depth of the diagnostic workup or in the breadth of treatments offered.
Hearing has to be “learnt.” While the cochlea is mature by week 23 of gestation, the development of auditory processing and perception requires binaural hearing ability and takes more than a decade to emerge [30]. This is the only way that elements such as redundancy and the head shadow, squelch, and cocktail party effects can come into play to permit sound localization, speech perception in background noise, and spatial hearing (see Table 1).
By contrast, adults and children with unilateral hearing loss (UHL) experience difficulties with sound localization [55]. Even a proposed compensatory mechanism is not a true substitute for the sound localization achieved with normal binaural hearing [28]. In addition, UHL and lack of head shadow mean that the speech signal cannot be separated from background noise [31]. Speech perception is reduced in background noise [13, 55] but also in quiet conditions [13].
Inadequate reception of acoustic stimuli and irregular stimulation of the central auditory system can have repercussions for the development of hearing ability. In early-onset hearing impairment, in particular, moderate and severe UHL can have adverse effects on the child’s verbal-cognitive, linguistic, communicative, and socio-emotional development [9–11, 14, 18, 69].
Positive developments have been recorded in the field of UHL in terms of age at diagnosis, available treatment modalities, and treatment recommendations.
Whereas UHL used to be diagnosed in preschoolers or early school-aged children [10, 22, 34, 67, 69], initial diagnosis can now be made in the third month of life thanks to the high quality of universal newborn hearing screening (UNHS) [56].
Technical advances have made it possible to provide behind-the-ear (BTE) hearing aids and bone-anchored hearing aids (BAHA) instead of a contralateral routing of signal (CROS) system. Frequency modulation (FM) systems are used in schools, where clearer auditory information and elimination of background noise can improve concentration. Cochlear implants (CIs) are increasingly being used in children, and treatment recommendations have been issued at the international level [3, 20].
Despite these developments, a scientific basis for standardized diagnostic workup, counseling, and treatment is still wanting. Thirty years ago, Bess and Tharpe observed academic deficits in children with UHL [10], and yet decades later we still lack any large prospective studies or an international database with results from validated tests or from gold-standard pediatric audiological and radiological diagnostics.
Materials and methods
To evaluate the impact of hearing aid provision versus non-provision on quality of hearing and quality of life, the medical records of a total of 152 children with hearing loss were reviewed. Within this sample, data were analyzed retrospectively for 107 children with UHL treated in the Department of Voice, Speech and Hearing Disorders, University Medical Center, Hamburg-Eppendorf (UKE), or in the Werner Otto Institut (WOI), Department of Phoniatrics and Pediatric Audiology. Both centers are staffed by multi-disciplinary expert teams experienced in the prevention, diagnosis, and treatment of pediatric hearing loss and speech disorders. The patients who provided retrospective data for the present study comprised all children who had been diagnosed with and routinely monitored and/or treated for UHL in these two units.
The children taking part were born in the period between February 1990 and September 2004 and at the time of the study were between 4 and 18 years old, giving an observation period of 162 months (13.5 years). The mean age of all 87 children observed was 10.2 years. Twenty children were excluded from the study because they had a global physical and mental disability or acute inflammation of the outer, middle, and inner ear or because important audiometric data were missing.
The study was approved by the ethics committee of the Hamburg regional medical board.
The diagnosis of UHL was made by careful pediatric audiological testing. Hearing loss was interpreted as an average hearing loss greater than 21 dB at frequencies of 0.5, 1, 2, and 4 kHz [8, 46, 58, 70]. Functional gain (the difference between audiometric curves recorded in the aided and unaided subject on exposure to tones and sounds) was determined, and the improvement in auditory threshold under aided conditions was described in terms of levels (1, 2, or 3, as defined in Table 2).
Three groups were formed: children (A) with and (B) without hearing aids and (C) children previously fitted with hearing aids. No child was supplied with a cochlear implant.
Various questionnaires were used (Table 3). From the pool of questions used for the “Living with Hearing Disorders” project, a 23-item questionnaire was designed and sent out. Analysis of the questionnaire was limited purely to the descriptive level, the aim being to address relevant problem areas and to identify any trends. It was not possible to compare this purely descriptive analysis of the pediatric questionnaire with the analysis of the DISABKIDS parental questionnaire.
The questionnaires were sent separately to parents/legal guardians and children, together with an information sheet and a consent form.
Results
The retrospective study covered the period from February 1990 to November 2007.
Audiological data were evaluated from 87 children (34 children (A) with and (B) 43 children without hearing aids and (C) 10 children previously fitted with hearing aids). Questionnaires were sent to 87 families, and responses were received from 74 families (85%): in detail, responses were received for 32 children currently with a hearing aid, 32 children without a hearing aid, and 10 children previously with a hearing aid.
The three groups (A, B, and C) showed virtually no differences in terms of demographic data: age, observation period, side (right/left), gender, type of school, age at initial diagnosis, age at hearing aid provision, and speech development (see Table 3).
The hearing of 48.6% of children currently or previously with a hearing aid and supplying valid audiometry data improved by one level. Two- and three-level improvements were recorded in 16.2 and 21.6% of these children, respectively. (Seven out of the total of 44 children currently or previously provided with a hearing aid had no audiometric data for improvement following hearing aid prescription.)
More than half of the children with hearing aids felt that their directional hearing and selective hearing in quiet and noisy environments had improved.
Hearing aid acceptance was high. Irrespective of the degree of hearing loss, time of hearing aid provision, family circumstances, number of household members, and the working hours of both parents, the hearing aids were worn for more than 8 h a day. Not quite 60% of parents reported a marked improvement as a result of hearing aid provision.
Compared with chronically ill children from the DISABKIDS Project, children with UHL scored better in all areas of health-related quality of life (HRQoL). The two groups scored very differently on the “Emotion” and “Physical limitations” subscales.
In the individual groups (A, B, and C), parental assessments of HRQoL of children with UHL showed hardly any differences in terms of independence, emotion, social inclusion, social exclusion, physical limitations, and treatment, with scores ranging from 71.2 to 90.1%.
General quality of life for children with UHL (n = 32) currently supplied with a hearing aid showed a mean score of 81.9%. Modified HRQoL (modified in the sense of extracting the hearing aid-related questions) was compared between the three groups of children currently with a hearing aid (n = 32), without a hearing aid (n = 32), and previously with a hearing aid (n = 10). All three groups had mean HRQoL scores in excess of 80% (83.3, 85.9, and 82.5%, respectively).
Review and discussion of the current literature
Definition, incidence, and prevalence
UHL is a mild to severe hearing impairment, bordering on deafness in one ear with normal hearing in the other ear. It includes chronic conductive, sensorineural, and combined hearing losses [3].
The most common congenital condition is hearing loss and affects 1 to 3 per 1000 live births [3].
The prevalence of UHL in US adolescents between the ages of 12 and 19 years rose from 11% in 1988–1994 to 14% in 2005–2006 [63]. Prevalence estimates for UHL may vary by as much as a factor of 2 with various applications of commonly accepted case definitions. A general consensus is needed to define the parameters (threshold levels, tympanometry status, and pure-tone audiometry frequencies) to be used as a basis for prevalence rate estimates [57].
Etiology and prognosis
The etiology of UHL is unknown in 35% [14] to 60% [22, 35] of cases. In addition to inherited syndromic or non-syndromic hearing loss, acquired prenatal and perinatal UHL may also develop [49]: high-tone hearing losses have been reported in hydrocephalic children, occurring in the ear ipsilateral to shunt placement in 83% of cases [64]. The most common causes of postnatal acquired UHL are neurotropic viruses (e.g., cytomegalovirus (CMV)) and head trauma [14]. Presence of progressive hearing loss is found in 14 to 32.8% of cases [7, 69] and is a predictor of abnormal computed tomography (CT) outcome [7]. However, pathological CT findings are not dependent on the degree of hearing loss, a positive family history, or consanguinity. CT scans of the petrous bone have revealed abnormalities—such as dilated vestibular aqueduct(s)—in 31 to 44% of cases, sometimes bilaterally [7, 48]. The possibility of progression from unilateral to bilateral hearing loss must also be recognized [48]. In one study, two thirds of asymptomatic CMV-infected children suffered subsequent deterioration of hearing, starting as UHL in 78% of cases [71].
Speech development/general development/school career
Some form of speech development disorder is found in 2 to 15% of 4- to 6-year-olds [6].
In our retrospective study, 14.9% of the children were “behind” in terms of speech development. No difference was found in this respect between children who were provided with a hearing aid and those who were not. As a caveat, it should be pointed out that the information on speech development was gleaned from case records, questionnaire responses, or reports from the doctor or therapist.
Few studies have specifically investigated speech using language tests in children aged between 3 and 12 years who have UHL but no other impairment [13, 43, 44, 53, 55]. These studies covered a variety of facets, such as type of hearing loss, degree of hearing loss, and test materials for investigating receptive and expressive language knowledge. There is no gold standard for language testing in children with UHL [32]. The speech problems presented do not indicate the formal and non-formal language levels where these problems are manifest. Children with UHL have poorer test results in expressive and receptive tests than their normal-hearing peers [43, 44]. Children with UHL scored better in expressive language tests than children with mild bilateral, severe, or conductive hearing loss [13]. The significant differences seen in 4- to 5-year-old children with severe UHL bordering on deafness compared with normal-hearing peers could no longer be detected by the age of 6 years [13].
In a recent prospective longitudinal study, individualized education plans and higher baseline cognitive levels were predictors of better results over time in standardized cognitive and language tests [42], but without any improvement in academic performance. The results could not be generalized to all degrees of hearing loss (severe hearing loss bordering on deafness was noted in most cases (61%)), and any continuing impact through to their working career was not ascertained.
Early-onset, perinatal, and/or postnatal complications as well as profound right-sided hearing loss bordering on deafness increase the risk of deficient academic performance (Table 4) [11, 14, 18, 43, 44, 66, 67].
Noise levels in classrooms are rising because of changes in teaching methods (working in pairs and groups instead of traditional teaching from the front). Where acoustics are poor, “normal-hearing” students at the back pick up only 60% of the information being communicated [45, 47]. The principal reasons are background noise and reverberation. In rooms with adverse acoustic conditions (reverberation time >0.55 s), communication difficulties may arise which cannot be accounted for by a poorer teacher-pupil relationship [38].
Certain aspects of auditory processing are not fully developed in childhood [52]. A normal-hearing pupil in grade 1 requires a greater signal-to-noise ratio (SNR) for 95% intelligibility than a grade 6 pupil does (Fig. 1; modified from [72]). Children with UHL need an even greater SNR [60] and face particular challenges against such a background. The behavioral problems of children with UHL are thought to be due to hearing loss and the associated deficits in attention and communication [66]. The proportion of behavioral problems and difficulties with classmates of the same age can be 2.4 times higher than in normal-hearing pupils. Children who have poorer communication skills and integrate less well into the class are affected to a greater extent. Socio-emotional development is not dependent on gender, age, or hearing status. Hintermair and Wiegand [24] conclude that teachers must ensure that communication is encouraged in children with UHL, enabling them to participate actively in lessons. Involving them in the social environment might foster better socio-emotional development, although future studies will be required to demonstrate this [24].
Audiological diagnostic workup: scope and limitations
The UNHS performance targets for the audiological diagnostic workup are not always adhered to because the importance and purpose of the particular measuring techniques are not properly understood [56].
Transient evoked otoacoustic emissions (TEOAEs) are detected using a series of click stimuli with a broad frequency range between 1000 and 4000 Hz. Functional integrity of the outer hair cells is necessary for active and non-linear sound amplification by the inner ear [25].
A functional disorder of the inner and/or middle ear is frequently the underlying cause of abnormal OAEs. A defect of the outer hair cells and/or middle ear fluid results in failure to generate OAEs. The detected presence of OAEs does not necessarily indicate normal hearing. Where there is a functional disorder of the inner hair cell, synapse, or cochlear nerve, where efferent regulation of the outer hair cell is disrupted [1], and where hearing loss occurs between 21 and 30 dB and at very high or low frequencies, TEOAEs are detected even though auditory impairment is present. As a result, mild hearing losses are not picked up by OAE measurement during UNHS. To complete the diagnostic workup, frequency-specific brainstem evoked response audiometry (BERA) should be used when hearing loss is suspected. Free-field testing in infants does not detect UHL. Mild and unilateral hearing losses that are not diagnosed during the course of UNHS require hearing screening at a later stage. The Frequency Animal Sound Test (FAST4) or its successor, the multi-Frequency Animal Sound Test (mFAST), are validated measuring instruments.
Age at first diagnosis
At least for mild hearing losses <30 dB, it is currently unlikely that age at first diagnosis can be brought forward because even UNHS sometimes fails to detect such losses. In our study, the (mean) age at first diagnosis of 5.9 years is consistent with findings in the literature for children prior to the introduction of UNHS [35, 56].
Early intervention for hearing losses diagnosed before the age of 1 year
Early diagnosis calls for new strategies in early hearing and speech intervention.
Early diagnosis and intervention barely alter perceptions of stress in parents of infants with bilateral hearing loss compared with parents of healthy children. The empowerment concept assigns parents the decisive role in their child’s development, hence the need for family-centered work to strengthen the parent-child relationship and the family’s social networks, including the contribution of parents’ associations [61].
It might be appropriate to transpose these findings to children with UHL, but this would need to be verified empirically [personal communication from Professor Hintermair: 60].
Treatment
A range of treatment options are available with differing effects on the qualities of binaural hearing, and the nature and degree of hearing loss must clearly play a role in treatment choice (Table 5) [20].
Intervention at the 6-month stage (onset of crawling, greater distance from person speaking, and increasing background noise) helps to improve sound reception, speech perception, and stimulation of the central auditory system. Such measures may promote development of auditory processing and perception and counteract speech problems.
The subject of CI provision for patients with UHL was first addressed in 2008 [68]. Improved sound localization [5, 23, 33] and speech comprehension in quiet conditions [29] and in noise as a result of squelch and head shadow effects [5, 23, 33, 65] as well as improved directional hearing as a result of loudness difference [29] have been demonstrated in adults and/or children.
However, the results reported in children by Hassepass et al. [23] cannot (yet) be generalized because of post-lingual deafness, the associated binaural hearing experience and brief hearing deprivation, the small group size, and learning effects in the test-retest model.
A less significant beneficial effect has been found for BAHA and CROS than for CI, but there are possibly pseudo-binaural benefits [5].
In the retrospective study reported here, unilateral hearing aid provision produced an objective and demonstrable binaural hearing gain in both directional hearing and quality of selective hearing in quiet and noisy surroundings as well as in speech comprehension in noise in more than 50% of cases.
Acceptance of wearing hearing aids among children with mild to moderate hearing loss has been reported as high in some cases [34, 36], and our retrospective study revealed high acceptance over all grades of hearing loss. The assessment of our study results carried out suggests that even mild hearing losses (from an auditory threshold of 30 to 40 dB) should have the opportunity for hearing aid provision. Children who have an auditory threshold between 21 and 29 dB should, like all other children with UHL, be followed up regularly by a pediatric audiologist.
Despite the considerable progress made in the technological development of hearing systems, speech intelligibility in background noise and sound localization will remain challenges until the problem of parallel amplification of desired sound and ambient noise is solved. Signal processing strategies that eliminate impairment of the cocktail party effect are currently being developed [39].
Quality of life
Health-related quality of life (HRQoL) is a multi-dimensional construct based on measurements obtained in the domains of physical and mental well-being, everyday functioning, and social integration [15]. Alongside the audiological diagnostic workup, measurement of HRQoL is relevant when deciding on a treatment and assessing its outcome.
The instruments used to measure HRQoL may be generic or disease-specific.
Changes in the HRQoL of adults with UHL reflect improved speech intelligibility in background noise and improved sound localization. The largest effect sizes have been associated with CIs, followed by bone conduction hearing aids and BTE hearing aids [37].
A validated HRQoL instrument exists only for bilaterally deaf adolescents [54]. Similar instruments are still lacking for all other hearing-impaired children and adolescents. Attempts are being made with KINDL, KIDSCREEN, and DISABKIDS to remedy this shortcoming for all other hearing-impaired children [50].
Whereas KIDSCREEN is used to survey HRQoL in healthy and ill children and adolescents, DISABKIDS surveys HRQoL in children and adolescents with chronic illnesses. The two projects—KIDSCREEN and DISABKIDS—have engendered a third (“Living with Hearing Disorders”) which is setting out to develop a measure for HRQoL in hearing-impaired children and adolescents. The needs of—and the problems faced by—children provided with a hearing aid have been recognized [50].
An ideal instrument should be age-appropriate, contain brief and understandable questions, and reflect the following items: limitations in daily living due to hearing loss, benefit provided by the hearing aid in respect of those limitations, contribution to general quality of life made by the hearing aid, and general quality of life [19]. It is advisable to combine this with a questionnaire for parents and/or teachers; however, assessments offered in the parents’ questionnaire merit critical scrutiny because parents are not necessarily good reporters of their child’s quality of life [26].
Fundamental research
If it becomes established in the early sensitive period of childhood, aural preference is difficult to reverse [41]. Factors such as auditory deprivation and specific stimulation can lead to reorganization of the central auditory system, especially the auditory cortex [59].
The activity of the brain is increasingly being viewed from the perspective of functional integration and connectivity. The default mode network (DMN) denotes the network structures located in the temporal region that are functionally interconnected by intrinsic activity; the DMN is described as the “resting state network.” Subareas of the DMN, as the baseline of the brain, show activity in the context of daydreams, empathy, and awareness of others’ intentions [51]. Dysfunction of this intrinsic network plays a role in various conditions such as autism [16, 21], attention deficit hyperactivity disorder [16], and tinnitus [27]. UHL leads to reduced deactivation of the DMN during audio-visual tasks [62]. If self-awareness is not adequately suppressed during a task, the participant may become a “daydreamer.” The academic and behavioral deficits seen in children with UHL may therefore be mediated by deficiencies in the DMN [62].
Outlook
Once a diagnosis of UHL has been made, the traditional view prevalent in otorhinolaryngology circles is that unilateral hearing is the minimum requirement for adequate speech development and consequently hearing aid provision is unnecessary. However, analysis of the published evidence, including the aspect of auditory deprivation and other neurophysiological facts, supports the contention that a hearing aid should be provided before or at the end of the first year of life for every child with UHL for whom this is feasible. “Feasibility” can be assessed after appropriate pediatric audiological diagnostic testing, in-depth counseling of the parents, and consideration of the resultant burden on the family [20].
In its updated 2013 guidelines, the American Academy of Audiology stipulates that children with aidable UHL should be considered candidates for amplification in the impaired ear [2]. The DGPP has also incorporated a similar statement into its consensus paper [20].
To reduce auditory deprivation and the extent of auditory cortex reorganization [41], early diagnosis and treatment of children with UHL should be an integral part of prospective studies from the outset.
Abbreviations
- BAHA:
-
Bone-anchored hearing aids
- BERA:
-
Brainstem evoked response audiometry
- BTE:
-
Behind-the-ear (hearing aids)
- CI:
-
Cochlear implant(s)
- CMV:
-
Cytomegalovirus
- CROS:
-
Contralateral routing of signal
- CT:
-
Computed tomography
- DGPP:
-
German Society of Phoniatrics and Pediatric Audiology
- DMN:
-
Default mode network
- FAST:
-
Frequency Animal Sound Test
- FM:
-
Frequency modulation (systems)
- HRQoL:
-
Health-related quality of life
- mFAST:
-
Multi-Frequency Animal Sound Test
- OAE:
-
Otoacoustic emission(s)
- SNHL:
-
Sensorineural hearing loss
- SNR:
-
Signal-to-noise ratio
- TEOAE:
-
Transient evoked otoacoustic emission(s)
- UNHS:
-
Universal newborn hearing screening
References
Abdala C (2000) Distortion product otoacoustic emission (2f1-f2) amplitude growth in human adults and neonates. J Acoust Soc Am 107:446–456
American Academy of Audiology Pediatric Amplification (2013) Updated clinical practice guidelines for unilateral hearing loss. http://galster.net/wp-content/uploads/2013/07/AAA-2013-Pediatric-Amp-Guidelines.pdf
American Speech-Language-Hearing Association. http://www.asha.org/aud/articles/hearlosschild.htm
American Speech-Language-Hearing Association. (http://www.asha.org/public/hearing/Unilateral-Hearing-Loss-in-Children/)
Arndt S, Aschendorff A, Laszig R, Beck R, Schild C, Kroeger S, Ihorst G, Wesarg T (2011) Comparison of pseudo-binaural hearing to real binaural hearing rehabilitation after cochlear implantation in patients with unilateral deafness and tinnitus. Otol Neurotol 32:39–47. doi:10.1097/MAO.0b013e3181fcf271
AWMF (2013) Diagnostik von Sprachentwicklungsstörungen (SES), unter Berücksichtigung umschriebener Sprachentwicklungsstörungen (USES) (Synonym: Spezifische Sprachentwicklungsstörungen (SSES)). http://www.awmf.org/uploads/tx_szleitlinien/049006l_S2k_Sprachentwicklungsstoerungen_Diagnostik_2013-06_01.pdf
Bamiou DE, Savy L, O’Mahoney C, Phelps P, Sirimanna T (1999) Unilateral sensorineural hearing loss and its aetiology in childhood: the contribution of computerised tomography in aetiological diagnosis and management. Int J Pediatr Otorhinolaryngol 51:91–99
Bess FH, Dodd-Murphy JD, Parker RA (1998) Children with minimal sensorineural hearing loss: prevalence, educational performance, and functional health status. Ear Hear 17:1–11
Bess FH (1986) The unilaterally hearing-impaired child: a final comment. Ear Hear 7:52–54
Bess FH, Tharpe AM (1986) An introduction to unilateral sensorineural hearing loss in children. Ear Hear 7:3–13
Bess FH, Tharpe AM (1984) Unilateral hearing impairment in children. Pediatrics 74:206–216
Birbaumer N, Schmidt RF (1991) Biologische Psychologie, 2nd edn. Springer, Berlin, p. 482
Borg E, Risberg A, McAllister B, Undemar BM, Edquist G, Reinholdson AC, Wiking-Johnsson A, Willstedt-Svensson U (2002) Language development in hearing-impaired children. Establishment of a reference material for a ‘Language test for hearing-impaired children’, LATHIC. Int J Pediatr Otorhinolaryngol 65:15–26
Brookhouser PE, Worthington DW, Kelly WJ (1991) Unilateral hearing loss in children. Laryngoscope 101:1264–1272
Bullinger M (1997) Gesundheitsbezogene Lebensqualität und subjektive Gesundheit. Ein Überblick über den Stand der Forschung zu einem neuen Evaluationskriterium in der Medizin. Psychother Psychosom Med Psychol 47:76–91
Chantiluke K, Barrett N, Giampietro V, Brammer M, Simmons A, Rubia K (2015) Disorder-dissociated effects of fluoxetine on brain function of working memory in attention deficit hyperactivity disorder and autism spectrum disorder. Psychol Med 45:1195–1205. doi:10.1017/S0033291714002232
Cherry EC (1953) Some experiments on the recognition of speech, with one and two ears. J Acoust Soc Am 25:975–979
Dancer J, Burl NT, Waters S (1995) Effects of unilateral hearing loss on teacher responses to the SIFTER. Screening Instrument for Targeting Educational Risk. Am Ann Deaf 140:291–294
de Wolf MJ, Hol MK, Mylanus EA, Snik AF, Cremers CW (2011) Benefit and quality of life after bone-anchored hearing aid fitting in children with unilateral or bilateral hearing impairment. Arch Otolaryngol Head Neck Surg 137:130–138. doi:10.1001/archoto.2010.252
Deutsche Gesellschaft für Phoniatrie und Pädaudiologie. http://www.dgpp.de/cms/pages/de/profibereich.php
Doyle-Thomas KA, Lee W, Foster NE, Tryfon A, Ouimet T, Hyde KL, Evans AC, Lewis J, Zwaigenbaum L, Anagnostou E, NeuroDevNet ASD Imaging Group (2015) Atypical functional brain connectivity during rest in autism spectrum disorders. Ann Neurol 77:866–876. doi:10.1002/ana.24391
English K, Church G (1999) Unilateral hearing loss in children: an update for the 1990s. Lang Speech Hear Serv Sch 30:26–31
Hassepass F, Aschendorff A, Wesarg T, Kröger S, Laszig R, Beck RL, Schild C, Arndt S (2013) Unilateral deafness in children: audiologic and subjective assessment of hearing ability after cochlear implantation. Otol Neurotol 34:53–60. doi:10.1097/MAO.0b013e31827850f0
Hintermair M, Wiegand E (2011) Socio-emotional problems in children and adolescents with unilateral hearing loss. Z Audiol 50:130–137
Hoth S, Neumann K (2006) Die diagnostische Aussagekraft der otoakustischen Emissionen. Praktische Arbeitsmedizin 6:18–24
Huber M (2005) Health-related quality of life of Austrian children and adolescents with cochlear implants. Int J Pediatr Otorhinolaryngol 69:1089–1101
Husain FT, Schmidt SA (2014) Using resting state functional connectivity to unravel networks of tinnitus. Hear Res 307:153–162. doi:10.1016/j.heares.2013.07.010
Irving S, Moore DR (2011) Training sound localization in normal hearing listeners with and without a unilateral ear plug. Hear Res 280:100–108. doi:10.1016/j.heares.2011.04.020
Jacob R, Stelzig Y, Nopp P, Schleich P (2011) Audiological results with cochlear implants for single-sided deafness. HNO 59:453–460. doi:10.1007/s00106-011-2321-0
Johnson CE (2000) Children’s phoneme identification in reverberation and noise. J Speech Lang Hear Res 43:144–157
Johnstone PM, Nabelek AK, Robertson VS (2010) Sound localization acuity in children with unilateral hearing loss who wear a hearing aid in the impaired ear. J Am Acad Audiol 21:522–534. doi:10.3766/jaaa.21.8.4
José MR, Mondelli MF, Feniman MR, Lopes-Herrera SA (2014) Language disorders in children with unilateral hearing loss: a systematic review. Int Arch Otorhinolaryngol 18:198–203. doi:10.1055/s-0033-1358580
Kamal SM, Robinson AD, Diaz RC (2012) Cochlear implantation in single-sided deafness for enhancement of sound localization and speech perception. Curr Opin Otolaryngol Head Neck Surg 20:393–397. doi:10.1097/MOO.0b013e328357a613
Kiese-Himmel C (2002) Unilateral sensorineural hearing impairment in childhood: analysis of 31 consecutive cases. Int J Audiol 41:57–63
Kiese-Himmel C, Kruse E (2001) Unilateral hearing loss in childhood. An empirical analysis comparing bilateral hearing loss. Laryngorhinootologie 80:18–22
Kiese-Himmel C, Ohlwein S, Kruse E (2000) Acceptance of wearing hearing aids by children: a longitudinal analysis. HNO 48:758–764
Kitterick PT, Lucas L, Smith SN (2015) Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis. Audiol Neurootol 20(Suppl 1):79–86. doi:10.1159/000380753
Klatte M, Wegner M, Hellbrück J (2006) Lärm in der schulischen Umwelt und kognitive Leistungen bei Grundschulkindern. Teil B: Kognitionspsychologische Untersuchungen. Zwischenbericht zum Status Seminar des Programms "Lebensgrundlage Umwelt und ihre Sicherung" des Landes Baden-Württemberg (BWplus). http://www.bwplus.fzk.de ; Link: Publikationen
Kollmeier B (2012) http://www.zdf.de/deutscher-zukunftspreis/binaurale-hoergeraete-24911418.html
Konkle D, Schwartz DM (1981) Binaural amplification: a paradox. In: Bess FH, Freeman BA, Sinclair S (eds.) Amplification in education. Alexander Graham Bell Association for the Deaf, Washington, DC, pp 342–357
Kral A, Hubka P, Heid S, Tillein J (2013) Single-sided deafness leads to unilateral aural preference within an early sensitive period. Brain 136:180–193. doi:10.1093/brain/aws305
Lieu JE, Tye-Murray N, Fu Q (2012) Longitudinal study of children with unilateral hearing loss. Laryngoscope 122:2088–2095. doi:10.1002/lary.23454
Lieu JE, Tye-Murray N, Karzon RK, Piccirillo JF (2010) Unilateral hearing loss is associated with worse speech-language scores in children. Pediatrics 125:e1348–e1355. doi:10.1542/peds.2009-2448
Martínez-Cruz CF, Poblano A, Conde-Reyes MP (2009) Cognitive performance of school children with unilateral sensorineural hearing loss. Arch Med Res 40:374–379. doi:10.1016/j.arcmed.2009.05.008
Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, Macrae CN (2007) Wandering minds: the default network and stimulus-independent thought. Science 315:393–395
MacKay S, Gravel JS, Tharpe AM (2008) Amplification considerations for children with minimal or mild bilateral hearing loss and unilateral hearing loss. Trends Amplif 12:43–54
Meis M, Uygun A, Janott C, Hemmer-Schanze C, Hilge C, Kalhlert J, Schick A (2003) Zur Wirkung von aktiven und passiven raumakustischen Maßnahmen auf die Geräuschwahrnehmung und Lebensqualität von Schülern: Ergebnisse aus einer prospektiven Längsschnittstudie. Fortschritte der Akustik DAGA’03. Aachen: DEGA e.V., Oldenburg: 630–631
Neault M (2005) Progression from unilateral to bilateral loss. In: National workshop on mild and unilateral hearing loss: workshop proceedings. Breckenridge, CO. Centers for Disease Control and Prevention, pp 30–31. http://www.cdc.gov/ncbddd/hearingloss/documents/unilateral/mild_uni_2005-workshop_proceedings.pdf
Nickisch A, Massinger C, Ertl-Wagner B, von Voss H (2009) Pedaudiologic findings after severe neonatal hyperbilirubinemia. Eur Arch Otorhinolaryngol 266:207–212. doi:10.1007/s00405-008-0737-2
Oflaz E (2009) Dissertation zur gesundheitsbezogenen Lebensqualität von schwerhörigen Kindern mit Hörgeräten. Zentrum für Psychosoziale Medizin des Universitätsklinikums Hamburg-Eppendorf Institut und Poliklinik für Medizinische Psychologie Prof. Dr. Dr. Martin Härter. http://ediss.sub.uni-hamburg.de/volltexte/2010/4542/pdf/dr.Arbeit_pdf.pdf
Otti A, Gündel H, Wohlschläger A, Zimmer C, Sorg C, Noll-Hussong M (2012) Default mode network of the brain. Neurobiology and clinical significance. Nervenarzt 83(16):18–24. doi:10.1007/s00115-011-3307-6
Papso CF, Blood IM (1989) Word recognition skills of children and adults in background noise. Ear Hear 10:235–236
Paradise JL, Feldman HM, Campbell TF, Dollaghan CA, Colborn DK, Bernard BS, Rockette HE, Janosky JE, Pitcairn DL, Sabo DL, Kurs-Lasky M, Smith CG (2003) Early versus delayed insertion of tympanostomy tubes for persistent otitis media: developmental outcomes at the age of three years in relation to prerandomization illness patterns and hearing levels. Pediatr Infect Dis J 22:309–314
Patrick DL, Edwards TC, Skalicky AM, Schick B, Topolski TD, Kushalnagar P, Leng M, O’Neill-Kemp AM, Sie KS (2011) Validation of a quality-of-life measure for deaf or hard of hearing youth. Otolaryngol Head Neck Surg 145:137–145. doi:10.1177/0194599810397604
Priwin C, Jönsson R, Magnusson L, Hultcrantz M, Granström G (2007) Audiological evaluation and self-assessed hearing problems in subjects with single-sided congenital external ear malformations and associated conductive hearing loss. Int J Audiol 46:162–171
Rohlfs AK, Wiesner T, Drews H, Müller F, Breitfuss A, Schiller R, Hess M (2010) Interdisciplinary approach to design, performance, and quality management in a multicenter newborn hearing screening project: introduction, methods, and results of the newborn hearing screening in Hamburg (part I). Eur J Pediatr 169:1353–1360. doi:10.1007/s00431-010-1228-1
Ross DS, Visser SN, Holstrum WJ, Qin T, Kenneson A (2010) Highly variable population-based prevalence rates of unilateral hearing loss after the application of common case definitions. Ear Hear 31:126–133. doi:10.1097/AUD.0b013e3181bb69db
Ross DS, Holstrum WJ, Gaffney M, Green D, Oyler RF, Gravel JS (2008) Hearing screening and diagnostic evaluation of children with unilateral and mild bilateral hearing loss. Trends Amplif 12:27–34
Rouger J, Lagleyre S, Démonet JF, Fraysse B, Deguine O, Barone P (2012) Evolution of crossmodal reorganization of the voice area in cochlear-implanted deaf patients. Hum Brain Mapp 33:1929–1940. doi:10.1002/hbm.21331
Ruscetta MN, Arjmand EM, Pratt SR (2005) Speech recognition abilities in noise for children with severe-to-profound unilateral hearing impairment. Int J Pediatr Otorhinolaryngol 69:771–779
Sarimski K, Hintermair M (2014) Frühförderung hörgeschädigter Kinder: Stand der Forschung, empirische Analysen, pädagogische Konsequenzen. Median, Heidelberg
Schmithorst VJ, Plante E, Holland S (2014) Unilateral deafness in children affects development of multi-modal modulation and default mode networks. Front Hum Neurosci 8(164). doi:10.3389/fnhum.2014.00164
Shargorodsky J, Curhan SG, Curhan GC, Eavey R (2010) Change in prevalence of hearing loss in US adolescents. JAMA 304:772–778. doi:10.1001/jama.2010
Spirakis SE, Hurley RM (2003) Unilateral hearing loss in children with shunt-treated hydrocephalus. J Am Acad Audiol 14:510–517
Távora-Vieira D, Marino R, Acharya A, Rajan GP (2015) The impact of cochlear implantation on speech understanding, subjective hearing performance, and tinnitus perception in patients with unilateral severe to profound hearing loss. Otol Neurotol 36:430–436. doi:10.1097/MAO.0000000000000707
Tharpe AM (2008) Unilateral and mild bilateral hearing loss in children: past and current perspectives. Trends Amplif 12:7–15. doi:10.1177/1084713807304668
Tieri L, Masi R, Ducci M, Marsella P (1988) Unilateral sensorineural hearing loss in children. Scand Audiol Suppl 30:33–36
Van de Heyning P, Vermeire K, Diebl M, Nopp P, Anderson I, De Ridder D (2008) Incapacitating unilateral tinnitus in single-sided deafness treated by cochlear implantation. Ann Otol Rhinol Laryngol 117:645–652
Watier-Launey C, Soin C, Manceau A, Ployet MJ (1998) Necessity of auditory and academic supervision in patients with unilateral hearing disorder. Retrospective study of 175 children. Ann Otolaryngol Chir Cervicofac 115:149–155
Watkin PM, Baldwin M (2011) Identifying deafness in early childhood: requirements after the newborn hearing screen. Arch Dis Child 96:62–66. doi:10.1136/adc.2010.185819
Williamson WD, Demmler GJ, Percy AK, Catlin FI (1992) Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. Pediatrics 90:862–866
Yang W, Bradley JS (2009) Effects of room acoustics on the intelligibility of speech in classrooms for young children. J Acoust Soc Am 125(2):922–933. doi:10.1121/1.3058900
Acknowledgements
We would like to thank all the families for their time in participating in the retrospective study. We also owe a debt of gratitude to the DISABKIDS Project, in particular for the support of the Coordination Center in Hamburg (project partners: Professor Dr. Monika Bullinger, Professor Dr. Silke Schmidt, and Dr. habil. Corinna Petersen-Ewert) in providing the DISABKIDS software.
Authors’ contributions
A-KR and JF are joint principal authors who contributed equally to the retrospective study and to the literature review presented here. A-KR, JF, FM, and TW participated in the concept, design, and interpretation of the manuscript. JF and A-KR coordinated the study centers and patient inclusion, and JF was responsible for the practical conduct of the retrospective study. MH, TW, and MR provided the patients for the study, and ABr and AS were responsible for diagnostic testing. JF, FM, A-KR, and TW conceptualized the data analysis. JF, ABo, and TW developed the questionnaires for the retrospective study. A-KR, FM, TW, and JF drafted the manuscript, and all the listed authors have reviewed and approved the final version of the manuscript as submitted.
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This study was not funded.
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The authors declare that they have no conflict of interest.
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The study was approved by the ethics committee of the Hamburg regional medical board. All procedures performed in this study involving human participants were in accordance with the ethical standards of the ethics committee of the Hamburg regional medical board.
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Informed consent was obtained from all individual participants included in the study or their parents/legal guardians.
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Communicated by Peter de Winter
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Rohlfs, AK., Friedhoff, J., Bohnert, A. et al. Unilateral hearing loss in children: a retrospective study and a review of the current literature. Eur J Pediatr 176, 475–486 (2017). https://doi.org/10.1007/s00431-016-2827-2
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DOI: https://doi.org/10.1007/s00431-016-2827-2