Abstract
The molecular and enzymatic abnormalities of mitochondria in oxyphilic / oncocytic / Hürthle cells and their respective tumours are reviewed in a series of sections: ”Mitochondria, ageing, neurodegenerative diseases and cancer”, ”Mitochondrial abnormalities in Hürthle cells and Hürthle cells tumours”, ”Mitochondrion-related alterations in tumours with and without Hürthle cell/oncocytic features”, ”True and secondary oxyphilia”, and ”Bcl-2 expression, apoptosis and necrosis in Hürthle cell tumours and tumour-like lesions”. The clinicopathological and pathogenetic meaning of the data on record on these topics are discussed, with an emphasis on thyroid pathology.
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Received: 15 December 1999 / Accepted: 23 February
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Máximo, V., Sobrinho-Simões, M. Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Archiv 437, 107–115 (2000). https://doi.org/10.1007/s004280000219
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DOI: https://doi.org/10.1007/s004280000219