Abstract
The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride (1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage, exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution rate.
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Received: 20 January 2001 Accepted: 8 March 2001
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Fejér, I., Kata, M., Erös, I. et al. Release of cationic drugs from loaded clay minerals. Colloid Polym Sci 279, 1177–1182 (2001). https://doi.org/10.1007/s003960100527
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DOI: https://doi.org/10.1007/s003960100527