Abstract
An impressive body of work has established the current paradigm of atherosclerosis as an inflammatory process that promotes lesion development and progression. Early atheroma formation is characterized by leukocyte recruitment and expression of inflammatory mediators which is confounded in the context of hyperlipidemia. Evidence for an involvement of both innate and adaptive immunity in lesion formation has emerged, supporting a causal relation between the balance of pro- and anti–inflammatory cytokines and atherogenesis. The function of chemokines in distinct steps during mononuclear cell recruitment to vascular lesions has been studied in genetically deficient mice and other suitable models, and displays a high degree of specialization and cooperation. The contribution of platelet chemokines deposited on endothelium to monocyte arrest, differences in the presentation and involvement of chemokines between native and neointimal lesion formation, and related functions of macrophage migration inhibitory factor, a cytokine with striking structural homology to chemokines are of note. A novel role of chemokines in the recruitment of vascular progenitors during neointimal hyperplasia and in the recovery of endothelial denudation underscores their relevance for atherosclerotic vascular disease. The functional diversity of chemokines in vascular inflammation may potentially allow the selective therapeutic targeting of different atherosclerotic conditions.
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Abbreviations
- ApoE:
-
apolipoprotein E
- CCL:
-
CC chemokine ligand
- CCR:
-
CC chemokine receptor
- CD:
-
cluster of differentiation
- CXCL:
-
CXC chemokine ligand
- CXCR:
-
CXC chemokine receptor
- EC:
-
endothelial cell
- GRO:
-
growth-related oncogene
- IFN–γ:
-
interferon–γ
- IL:
-
interleukin
- KC:
-
keratinocyte–derived chemokine
- LDL–R:
-
low density lipoprotein receptor
- MCP:
-
monocyte chemotactic protein
- MIF:
-
macrophage migration inhibitory factor
- Mig/IP10:
-
monokine induced by IFN–γ/IFN–γ–inducible protein–10
- RANTES:
-
regulated on activation normal T cell expressed and secreted
- SDF:
-
stromal cell–derived factor
- SMC:
-
smooth muscle cell
- TGF–β:
-
transforming growth factor–β
- TNF:
-
tumor necrosis factor
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Zernecke, A., Weber, C. Inflammatory mediators in atherosclerotic vascular disease. Basic Res Cardiol 100, 93–101 (2005). https://doi.org/10.1007/s00395-005-0511-6
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DOI: https://doi.org/10.1007/s00395-005-0511-6