Abstract
We investigated the age-related location, gender distribution, and histology of 75 brain tumors in children under 3 years of age seen in our department between 1984 and 1997. These were characterized by a higher overall incidence in boys (42/33 cases; ratio 1.3) and a prevalence for a supratentorial location (48/27 cases; ratio 1.7); the most common histological entities were astrocytoma (25.3%) and ependymoma (17.3%), followed by medulloblastoma (13.3%) and PNET (10.8%); 44% were high-grade tumors corresponding to WHO grades III and IV. In the 1st (22 cases), 2nd (25 cases) and 3rd (28 cases) years of life, the boy–girl ratios were 1.0, 1.5 and 1.3, respectively, while there was a decrease with age in the frequency of supratentorial (ratios 3.4, 1.1, and 1.2) and high-grade tumors (77.3%, 36.0%, and 32.1%). In the 1st year of life the most common neoplasms were PNETs (22.7%) and in the 2nd year both astrocytomas and ependymomas (24.0% each); astrocytomas (35.7%) prevailed in the 3rd year of life.
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Received: 10 May 1998
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Rickert, C. Epidemiological features of brain tumors in the first 3 years of life. Child's Nerv Syst 14, 547–550 (1998). https://doi.org/10.1007/s003810050270
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DOI: https://doi.org/10.1007/s003810050270