Abstract
Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2–4), two ceramides (5 and 6), six aromatic compounds (7–12), and three alkaloids (13–15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).
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Supported by the Ministry of Science and Technology (No. 2010CB833802), the Knowledge Innovation Program of Chinese Academy of Sciences (No. KSCX2-EW-G-12B), and the National Natural Science Foundation of China (No. 30910103914)
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Shang, Z., Li, X., Meng, L. et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118. Chin. J. Ocean. Limnol. 30, 305–314 (2012). https://doi.org/10.1007/s00343-012-1075-1
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DOI: https://doi.org/10.1007/s00343-012-1075-1