Abstract
Highly sensitive, sequence-specific and label-free DNA sensors were demonstrated by monitoring the electronic conductance of silicon nanowires (SiNWs) with chemically bonded single-stranded (ss) DNA or peptide nucleic acid (PNA) probe molecules. For a 12-mer oligonucleotide, tens of pM of target ss-DNA in solution was recognized when the complementary DNA oligonucleotide probe was attached to the SiNW surfaces. In contrast, ss-DNA samples of ×1000 concentration with a single-base mismatch produce only a weak signal due to nonspecific binding. In order to gain a physical understanding of the change in conductance of the SiNWs with the attachment of the DNA targets and the probes, process and device simulations of the two-dimensional cross sections of the SiNWs were performed. The simulations explained the width dependence of the SiNW conductance and provided understanding to improve the sensor performance.
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85.35.-p; 87.83.+a; 07.07.Df
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Li, Z., Rajendran, B., Kamins, T. et al. Silicon nanowires for sequence-specific DNA sensing: device fabrication and simulation. Appl. Phys. A 80, 1257–1263 (2005). https://doi.org/10.1007/s00339-004-3157-1
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DOI: https://doi.org/10.1007/s00339-004-3157-1