Abstract.
Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.
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An erratum to this article is available at http://dx.doi.org/10.1007/s00330-002-1497-9.
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Huisman, T., Thiel, T., Steinmann, B. et al. Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: in vivo–in vitro (ex vivo) correlation. Eur Radiol 12, 858–861 (2002). https://doi.org/10.1007/s003300101073
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DOI: https://doi.org/10.1007/s003300101073