Summary
Polymeric micelles have found numerous applications in the area of biomedical engineering, including the delivery of bioactive molecules. Block copolymers, typical polymeric amphiphiles, form micelles in aqueous phases containing a hydrophobic inner core and hydrophilic outer shell. The unique characteristics of polymeric micelles are mainly controlled by the chemical structure and length of the hydrophilic and hydrophobic blocks. In this study we hypothesized that the solubility parameter values of the organic solvents typically used to dissolve the polymeric amphiphiles and eventually removed from an aqueous phase could significantly influence the characteristics of the resultant micelles in an aqueous phase. Poly(2-ethyl-2-oxazoline)-b-poly(ε-caprolactone) (PEtOz-b-PCL) was synthesized and dissolved in various organic solvents to prepare micelles in water. Their various physicochemical characteristics were investigated by the dynamic light scattering method and fluorescence spectroscopy.
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References
Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R (1994) Science 263:1600
Xu R, Winnik MA, Hallett FR, Riess G, Croucher MD (1991) Macromolecules 24:87
Hurter PN, Hatton TA (1992) Langmuir 8:1291
Kwon GS, Suwa S, Yokoyama M, Okano T, Sakurai Y, Kataoka K (1994) J Controlled Release 29:17
Yu K, Eisenberg A (1996) Macromolecules 29:6359
Yokoyama M, Kwon GS, Okano T, Sakurai Y, Seto T, Kataoka K (1992) Bioconjugate Chem 3:295
Gao Z, Varshney SK, Wong S, Eisenberg A (1994) Macromolecules 27:7923
Kataoka K, Kwon GS, Yokoyama M, Okano T, Sakurai Y (1993) J Controlled Release 24:119
Lee ES, Na K, Bae YH (2005) J Controlled Release 103:405
Yoo HS, Park TG (2004) J Controlled Release 96:273
Wilhelm M, Zhao C, Wang Y, Xu R, Winnik MA, Mura J, Riess G, Croucher MD (1991) Macromolecules 24:1033
Calde’rara F, Hruska Z, Hurtrez G, Lerch J, Nugay T, Riess G (1994) Macromolecules 27:1210
Xu R, Winnik MA, Riess G, Chu B, Croucher MD (1992) Macromolecules 25:644
Nagasaki Y, Okada T, Scholz C, Iijima M, Kato M, Kataoka K (1998) Macromolecules 31:1473
Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K (1993) Langmuir 9:945
Kabanov AV, Nazarova IR, Astafieva IV, Batrakova EV, Alakhov VY, Yaroslavov AA, Kabanov VA (1995) Macromolecules 28:2303
Poppe A, Willner L, Allgaier J, Stellbrink J, Richter D (1997) Macromolecules 30:7462
Kwon IC, Bae YH, Kim SW (1991) Nature 354:291
Lee SC, Chang Y, Yoon JS, Kim C, Kwon IC, Kim YH, Jeong SY (1999) Macromolecules 32:1847
Kim C, Lee SC, Kang SW, Kwon IC, Jeong SY (2000) J Polym Sci Polym Phys Edn 38:2400
Lee KY, Jo WH, Kwon IC, Kim YH, Jeong SY (1998) Macromolecules 31:378
Provencher SW (1982) Comput Phys Commun 27:213
Ringsdorf H, Venzmer J, Winnik FM (1991) Macromolecules 24:1678
Jette KK, Law D, Schmitt EA, Kwon GS (2004) Pharm Res 21:1184
Lin Y, Alexandridis P (2002) Langmuir 18:4220
Zhang L, Shen H, Eisenberg A (1997) Macromolecules 30:1001
Small PA (1953) J Appl Chem 3:71
Barton AFM (1990) Handbook of polymers – liquid interaction parameters and solubility parameters. CRC, Boca Raton
Brandup J, Immergut EH (1989) Polymer handbook (3rd Ed.). John Wiley and Sons, New York
McGlade MJ, Randall FJ, Tcheurekdjian N (1987) Macromolecules 20:1782
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Lee, K., Kwon, I. & Jeong, S. Physicochemical characteristics of poly(2-ethyl-2-oxazoline)/poly(ε-caprolactone) block copolymer micelles in water. Polym. Bull. 56, 385–393 (2006). https://doi.org/10.1007/s00289-005-0497-8
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DOI: https://doi.org/10.1007/s00289-005-0497-8