Abstract
We report a case of a 4-week-old female who presented with late hemorrhagic disease of the newborn (HDN). The newborn was previously healthy, and she received 1 mg of intramuscular vitamin K at birth. She was exclusively breast-fed. At 4 weeks she began bleeding at the umbilicus and 4 days after she suffered an intracranial hemorrhage. Coagulation studies showed a deficiency of vitamin K-dependent coagulation factors, and the normalization of all clotting studies after administration of vitamin K confirmed the diagnosis of HDN. Our conclusions are that physicians must be alert to mild bleeding in newborns and that prophylaxis with 1 mg of intramuscular vitamin K at birth may be insufficient to prevent late HDN.
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Received: 18 March 1996/Accepted: 6 June 1997
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Solves, P., Altés, A., Ginovart, G. et al. Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding. Ann Hematol 75, 65–66 (1997). https://doi.org/10.1007/s002770050314
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DOI: https://doi.org/10.1007/s002770050314