Abstract.
Injury produces tissue hypoperfusion and subsequent reperfusion, afferent neural activity, and immune and vascular endothelial activation. These, in turn, set up a cascade of events coordinated by the central nervous system and at the level of individual tissues such as the liver, gut, and skeletal muscle. They are mediated by a complex array of neutrophil and macrophage products. The changes result in hypermetabolism, lypolysis, lysis of skeletal muscle and visceral protein, and expanded extracellular fluid with consequent organ failure.
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Hill, A. Initiators and Propagators of the Metabolic Response to Injury. World J. Surg. 24, 624–629 (2000). https://doi.org/10.1007/s002689910103
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DOI: https://doi.org/10.1007/s002689910103